{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T19:09:23Z","timestamp":1776107363004,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T00:00:00Z","timestamp":1520208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI-043596 to W. A. P."],"award-info":[{"award-number":["R01 AI-043596 to W. A. P."]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1100514"],"award-info":[{"award-number":["OPP1100514"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wellcome Trust Sanger Institute","award":["206194"],"award-info":[{"award-number":["206194"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32AI055432"],"award-info":[{"award-number":["T32AI055432"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,20]]},"abstract":"<jats:p>In the developing world, Cryptosporidium is one of the top causes of infant diarrhea. In a Bangladesh community we have discovered that a substantial amount of genetic recombination and genetic polymorphism in surface proteins occurs in the Cryptosporidium hominis parasite.<\/jats:p>","DOI":"10.1093\/infdis\/jiy121","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T20:11:42Z","timestamp":1519935102000},"page":"259-264","source":"Crossref","is-referenced-by-count":60,"title":["Genetic Diversity of Cryptosporidium hominis in a Bangladeshi Community as Revealed by Whole-Genome Sequencing"],"prefix":"10.1093","volume":"218","author":[{"given":"Carol A","family":"Gilchrist","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Virginia, Charlottesville"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A","family":"Cotton","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecelia","family":"Burkey","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Virginia, Charlottesville"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuhinur","family":"Arju","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allissia","family":"Gilmartin","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Virginia, Charlottesville"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of Virginia, Charlottesville"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emtiaz","family":"Ahmed","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Steiner","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Virginia, Charlottesville"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masud","family":"Alam","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahnawaz","family":"Ahmed","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Robinson","sequence":"additional","affiliation":[{"name":"Cryptosporidium Reference Unit, Public Health Wales Microbiology, Singleton Hospital"},{"name":"Swansea University Medical School, Singleton Park, Swansea, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sultan Uz","family":"Zaman","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5100-136X","authenticated-orcid":false,"given":"Mamun","family":"Kabir","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandy","family":"Sanders","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel M","family":"Chalmers","sequence":"additional","affiliation":[{"name":"Cryptosporidium Reference Unit, Public Health Wales Microbiology, Singleton Hospital"},{"name":"Swansea University Medical School, Singleton Park, Swansea, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahmeed","family":"Ahmed","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennie Z","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, University of Virginia, Charlottesville"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashidul","family":"Haque","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abu S G","family":"Faruque","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Berriman","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A","family":"Petri","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Virginia, Charlottesville"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,3,5]]},"reference":[{"key":"2019121022383979400_CIT0001","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/00001432-200210000-00012","article-title":"Cryptosporidiosis","volume":"15","author":"Chappell","year":"2002","journal-title":"Curr Opin Infect Dis"},{"key":"2019121022383979400_CIT0002","doi-asserted-by":"crossref","first-page":"e0004729","DOI":"10.1371\/journal.pntd.0004729","article-title":"The burden of Cryptosporidium diarrheal disease among children &lt;24 months of age in moderate\/high mortality regions of sub-Saharan Africa and South Asia, utilizing data from the Global Enteric Multicenter Study (GEMS)","volume":"10","author":"Sow","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"2019121022383979400_CIT0003","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S1473-3099(17)30276-1","article-title":"Estimates of global, regional, and national morbidity, mortality, and aetiologies of diarrhoeal diseases: a systematic analysis for the Global Burden of Disease Study 2015","volume":"17","author":"GBD Diarrhoeal Diseases Collaborators","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"2019121022383979400_CIT0004","doi-asserted-by":"crossref","first-page":"e0004564","DOI":"10.1371\/journal.pntd.0004564","article-title":"Natural history of cryptosporidiosis in a longitudinal study of slum-dwelling Bangladeshi children: association with severe malnutrition","volume":"10","author":"Korpe","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"2019121022383979400_CIT0005","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.trstmh.2005.12.012","article-title":"Entamoeba histolytica-associated diarrheal illness is negatively associated with the growth of preschool children: evidence from a prospective study","volume":"100","author":"Mondal","year":"2006","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2019121022383979400_CIT0006","article-title":"Species of cryptosporidia causing subclinical infection associated with growth faltering in rural and urban Bangladesh: a birth cohort study. Clin Infect Dis ciy310; doi:10.1093\/cid\/ciy310","author":"Steiner"},{"key":"2019121022383979400_CIT0007","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/S1473-3099(14)70808-4","article-title":"Development and assessment of molecular diagnostic tests for 15 enteropathogens causing childhood diarrhoea: a multicentre study","volume":"14","author":"Liu","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"2019121022383979400_CIT0008","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1086\/519842","article-title":"Differences in clinical manifestations among Cryptosporidium species and subtypes in HIV-infected persons","volume":"196","author":"Cama","year":"2007","journal-title":"J Infect Dis"},{"key":"2019121022383979400_CIT0009","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1186\/s12864-015-1805-9","article-title":"Generation of whole genome sequences of new Cryptosporidium hominis and Cryptosporidium parvum isolates directly from stool samples","volume":"16","author":"Hadfield","year":"2015","journal-title":"BMC Genomics"},{"key":"2019121022383979400_CIT0010","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/0035-9203(89)90274-5","article-title":"Occurrence and significance of Cryptosporidium infection in Calcutta","volume":"83","author":"Pal","year":"1989","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2019121022383979400_CIT0011","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1017\/S0031182015001766","article-title":"Suitability of loci for multiple-locus variable-number of tandem-repeats analysis of Cryptosporidium parvum for inter-laboratory surveillance and outbreak investigations","volume":"144","author":"Chalmers","year":"2017","journal-title":"Parasitology"},{"key":"2019121022383979400_CIT0012","volume-title":"Genetic data analysis II: methods for discrete population genetic data","author":"Weir","year":"1996"},{"key":"2019121022383979400_CIT0013","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1752-4571.2012.00277.x","article-title":"A new heterogeneous family of telomerically encoded Cryptosporidium proteins","volume":"6","author":"Bouzid","year":"2013","journal-title":"Evol Appl"},{"key":"2019121022383979400_CIT0014","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/s12864-015-1517-1","article-title":"Comparative genomic analysis reveals occurrence of genetic recombination in virulent Cryptosporidium hominis subtypes and telomeric gene duplications in Cryptosporidium parvum","volume":"16","author":"Guo","year":"2015","journal-title":"BMC Genomics"},{"key":"2019121022383979400_CIT0015","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1128\/JCM.01798-16","article-title":"Genomic variation in IbA10G2 and other patient-derived Cryptosporidium hominis subtypes","volume":"55","author":"Sikora","year":"2017","journal-title":"J Clin Microbiol"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/218\/2\/259\/25068491\/jiy121.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/218\/2\/259\/25068491\/jiy121.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T03:41:31Z","timestamp":1576035691000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/218\/2\/259\/4920861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,5]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,3,5]]},"published-print":{"date-parts":[[2018,6,20]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiy121","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,7,15]]},"published":{"date-parts":[[2018,3,5]]}}}