{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:38:15Z","timestamp":1791272295933,"version":"4.1.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2018,5,26]],"date-time":"2018-05-26T00:00:00Z","timestamp":1527292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Sanofi-Aviesan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,8]]},"DOI":"10.1093\/infdis\/jiy298","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T11:07:06Z","timestamp":1527073626000},"page":"1306-1313","source":"Crossref","is-referenced-by-count":43,"title":["Penetration of the Human Pulmonary Epithelium by Aspergillus fumigatus Hyphae"],"prefix":"10.1093","volume":"218","author":[{"given":"Julien","family":"Fernandes","sequence":"first","affiliation":[{"name":"INSERM UMR1152, Physiopathologie et Epid\u00e9miologie des Maladies Respiratoires, Paris, France"},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris-Cit\u00e9, Facult\u00e9 de M\u00e9decine, site Bichat, France"},{"name":"Laboratory of Excellence INFLAMEX, Universit\u00e9 Sorbonne Paris-Cit\u00e9, France"},{"name":"D\u00e9partement Hospitalo-Universitaire FIRE, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Hamidi","sequence":"additional","affiliation":[{"name":"INSERM UMR1152, Physiopathologie et Epid\u00e9miologie des Maladies Respiratoires, Paris, France"},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris-Cit\u00e9, Facult\u00e9 de M\u00e9decine, site Bichat, France"},{"name":"Laboratory of Excellence INFLAMEX, Universit\u00e9 Sorbonne Paris-Cit\u00e9, France"},{"name":"D\u00e9partement Hospitalo-Universitaire FIRE, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remi","family":"Leborgne","sequence":"additional","affiliation":[{"name":"ImagoSeine Electron Microscopy Facility, Institut Jacques Monod, Centre National de la Recherche Scientifique UMR 7592, Universite\u0301 Paris Diderot, Sorbonne Paris-Cit\u00e9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remi","family":"Beau","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Aspergillus, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Castier","sequence":"additional","affiliation":[{"name":"INSERM UMR1152, Physiopathologie et Epid\u00e9miologie des Maladies Respiratoires, Paris, France"},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris-Cit\u00e9, Facult\u00e9 de M\u00e9decine, site Bichat, France"},{"name":"Laboratory of Excellence INFLAMEX, Universit\u00e9 Sorbonne Paris-Cit\u00e9, France"},{"name":"D\u00e9partement Hospitalo-Universitaire FIRE, Paris, France"},{"name":"Service de Chirurgie Thoracique, Groupement Hospitalier Universitaire Nord Bichat-Claude Bernard, Assistance Publique des Hopitaux de Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Mordant","sequence":"additional","affiliation":[{"name":"INSERM UMR1152, Physiopathologie et Epid\u00e9miologie des Maladies Respiratoires, Paris, France"},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris-Cit\u00e9, Facult\u00e9 de M\u00e9decine, site Bichat, France"},{"name":"Laboratory of Excellence INFLAMEX, Universit\u00e9 Sorbonne Paris-Cit\u00e9, France"},{"name":"D\u00e9partement Hospitalo-Universitaire FIRE, Paris, France"},{"name":"Service de Chirurgie Thoracique, Groupement Hospitalier Universitaire Nord Bichat-Claude Bernard, Assistance Publique des Hopitaux de Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Boukkerou","sequence":"additional","affiliation":[{"name":"INSERM UMR1152, Physiopathologie et Epid\u00e9miologie des Maladies Respiratoires, Paris, France"},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris-Cit\u00e9, Facult\u00e9 de M\u00e9decine, site Bichat, France"},{"name":"Laboratory of Excellence INFLAMEX, Universit\u00e9 Sorbonne Paris-Cit\u00e9, France"},{"name":"D\u00e9partement Hospitalo-Universitaire FIRE, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Paul","family":"Latg\u00e9","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Aspergillus, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Pretolani","sequence":"additional","affiliation":[{"name":"INSERM UMR1152, Physiopathologie et Epid\u00e9miologie des Maladies Respiratoires, Paris, France"},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris-Cit\u00e9, Facult\u00e9 de M\u00e9decine, site Bichat, France"},{"name":"Laboratory of Excellence INFLAMEX, Universit\u00e9 Sorbonne Paris-Cit\u00e9, France"},{"name":"D\u00e9partement Hospitalo-Universitaire FIRE, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,5,28]]},"reference":[{"key":"key\n\t\t\t\t20180908093328_CIT0001","first-page":"310","article-title":"Aspergillus fumigatus, a saprotrophic pathogenic fungus","volume":"17","author":"Latg\u00e9","year":"2003","journal-title":"Mycologist"},{"key":"key\n\t\t\t\t20180908093328_CIT0002","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1128\/CMR.12.2.310","article-title":"Aspergillus fumigatus and aspergillosis","volume":"12","author":"Latg\u00e9","year":"1999","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t20180908093328_CIT0003","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1128\/CMR.00055-08","article-title":"Pathogenesis of Aspergillus fumigatus in invasive aspergillosis","volume":"22","author":"Dagenais","year":"2009","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t20180908093328_CIT0004","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.micinf.2009.07.002","article-title":"The innate immune response to Aspergillus fumigatus","volume":"11","author":"Balloy","year":"2009","journal-title":"Microbes Infect"},{"key":"key\n\t\t\t\t20180908093328_CIT0005","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.mib.2010.04.009","article-title":"Interaction of phagocytes with filamentous fungi","volume":"13","author":"Brakhage","year":"2010","journal-title":"Curr Opin Microbiol"},{"key":"key\n\t\t\t\t20180908093328_CIT0006","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.ijmm.2011.04.012","article-title":"Phagocyte responses towards Aspergillus fumigatus","volume":"301","author":"Hasenberg","year":"2011","journal-title":"Int J Med Microbiol"},{"key":"key\n\t\t\t\t20180908093328_CIT0007","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3389\/fmicb.2012.00108","article-title":"Systems biology of fungal infection","volume":"3","author":"Horn","year":"2012","journal-title":"Front Microbiol"},{"key":"key\n\t\t\t\t20180908093328_CIT0008","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1128\/IAI.71.2.891-903.2003","article-title":"Phagocytosis and intracellular fate of Aspergillus fumigatus conidia in alveolar macrophages","volume":"71","author":"Ibrahim-Granet","year":"2003","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180908093328_CIT0009","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/02681219680000681","article-title":"Route of infections in bovine aspergillosis","volume":"34","author":"Sarfati","year":"1996","journal-title":"J Med Vet Mycol"},{"key":"key\n\t\t\t\t20180908093328_CIT0010","doi-asserted-by":"crossref","first-page":"S127","DOI":"10.1080\/13693780802558959","article-title":"Interaction of Aspergillus with human respiratory mucosa: a study with organ culture model","volume":"47","author":"Amitani","year":"2009","journal-title":"Med Mycol"},{"key":"key\n\t\t\t\t20180908093328_CIT0011","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1242\/jcs.00329","article-title":"Aspergillus fumigatus conidia survive and germinate in acidic organelles of A549 epithelial cells","volume":"116","author":"Wasylnka","year":"2003","journal-title":"J Cell Sci"},{"key":"key\n\t\t\t\t20180908093328_CIT0012","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1080\/13693780400029247","article-title":"Intracellular and extracellular growth of Aspergillus fumigatus","volume":"43","author":"Wasylnka","year":"2005","journal-title":"Med Mycol"},{"key":"key\n\t\t\t\t20180908093328_CIT0013","doi-asserted-by":"crossref","first-page":"e129","DOI":"10.1371\/journal.ppat.0020129","article-title":"Fungal invasion of normally non-phagocytic host cells","volume":"2","author":"Filler","year":"2006","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20180908093328_CIT0014","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.4049\/jimmunol.176.4.2465","article-title":"Transepithelial pathogen uptake into the small intestinal lamina propria","volume":"176","author":"Vallon-Eberhard","year":"2006","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20180908093328_CIT0015","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1165\/ajrcmb.22.6.3925","article-title":"Effects of TNF-alpha on expression of ICAM-1 in human airway epithelial cells in vitro. Signaling pathways controlling surface and gene expression","volume":"22","author":"Krunkosky","year":"2000","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key\n\t\t\t\t20180908093328_CIT0016","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1083\/jcb.57.2.551","article-title":"A technique for ultracryotomy of cell suspensions and tissues","volume":"57","author":"Tokuyasu","year":"1973","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20180908093328_CIT0017","doi-asserted-by":"crossref","first-page":"e1004413","DOI":"10.1371\/journal.ppat.1004413","article-title":"The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis","volume":"10","author":"Bertuzzi","year":"2014","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20180908093328_CIT0018","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1186\/1471-2164-11-358","article-title":"Functional genomics of human bronchial epithelial cells directly interacting with conidia of Aspergillus fumigatus","volume":"11","author":"Gomez","year":"2010","journal-title":"BMC Genomics"},{"key":"key\n\t\t\t\t20180908093328_CIT0019","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/infdis\/175.1.146","article-title":"Binding and germination of Aspergillus fumigatus conidia on cultured A549 pneumocytes","volume":"175","author":"DeHart","year":"1997","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20180908093328_CIT0020","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1016\/j.ajpath.2015.04.027","article-title":"Absence of fungal spore internalization by bronchial epithelium in mouse models evidenced by a new bioimaging approach and transmission electronic microscopy","volume":"185","author":"Rammaert","year":"2015","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20180908093328_CIT0021","doi-asserted-by":"crossref","first-page":"e20527","DOI":"10.1371\/journal.pone.0020527","article-title":"Dual organism transcriptomics of airway epithelial cells interacting with conidia of Aspergillus fumigatus","volume":"6","author":"Oosthuizen","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180908093328_CIT0022","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.3109\/13693786.2010.496119","article-title":"Primary in vitro culture of porcine tracheal epithelial cells in an air-liquid interface as a model to study airway epithelium and Aspergillus fumigatus interactions","volume":"48","author":"Khoufache","year":"2010","journal-title":"Med Mycol"},{"key":"key\n\t\t\t\t20180908093328_CIT0023","first-page":"1095","article-title":"Aspergillus fumigatus causes in vitro electrophysiological and morphological modifications in human nasal epithelial cells","volume":"17","author":"Botterel","year":"2002","journal-title":"Histol Histopathol"},{"key":"key\n\t\t\t\t20180908093328_CIT0024","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1086\/420850","article-title":"Involvement of secreted Aspergillus fumigatus proteases in disruption of the actin fiber cytoskeleton and loss of focal adhesion sites in infected A549 lung pneumocytes","volume":"189","author":"Kogan","year":"2004","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20180908093328_CIT0025","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1128\/IAI.00426-09","article-title":"Transcription factor PrtT controls expression of multiple secreted proteases in the human pathogenic mold Aspergillus fumigatus","volume":"77","author":"Sharon","year":"2009","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180908093328_CIT0026","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.4049\/jimmunol.168.3.1362","article-title":"Dendritic cells transport conidia and hyphae of Aspergillus fumigatus from the airways to the draining lymph nodes and initiate disparate Th responses to the fungus","volume":"168","author":"Bozza","year":"2002","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20180908093328_CIT0027","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.1090124","article-title":"Bacterial invasion: the paradigms of enteroinvasive pathogens","volume":"304","author":"Cossart","year":"2004","journal-title":"Science"},{"key":"key\n\t\t\t\t20180908093328_CIT0028","doi-asserted-by":"crossref","first-page":"e00622","DOI":"10.1128\/mBio.00622-16","article-title":"Identification and characterization of a candidate Wolbachia pipientis type IV effector that interacts with the actin cytoskeleton","volume":"7","author":"Sheehan","year":"2016","journal-title":"MBio"},{"key":"key\n\t\t\t\t20180908093328_CIT0029","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/mbo3.316","article-title":"Identification of regions within the Legionella pneumophila VipA effector protein involved in actin binding and polymerization and in interference with eukaryotic organelle trafficking","volume":"5","author":"Bugalh\u00e3o","year":"2016","journal-title":"Microbiologyopen"},{"key":"key\n\t\t\t\t20180908093328_CIT0030","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.micres.2014.02.013","article-title":"Fungal invasion of epithelial cells","volume":"169","author":"Yang","year":"2014","journal-title":"Microbiol Res"},{"key":"key\n\t\t\t\t20180908093328_CIT0031","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.1128\/IAI.69.7.4536-4544.2001","article-title":"Traversal of Candida albicans across human blood-brain barrier in vitro","volume":"69","author":"Jong","year":"2001","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180908093328_CIT0032","doi-asserted-by":"crossref","first-page":"e36952","DOI":"10.1371\/journal.pone.0036952","article-title":"Candida albicans-epithelial interactions: dissecting the roles of active penetration, induced endocytosis and host factors on the infection process","volume":"7","author":"W\u00e4chtler","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180908093328_CIT0033","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1111\/j.1462-5822.2009.01319.x","article-title":"Candida albicans internalization by host cells is mediated by a clathrin-dependent mechanism","volume":"11","author":"Moreno-Ruiz","year":"2009","journal-title":"Cell Microbiol"},{"key":"key\n\t\t\t\t20180908093328_CIT0034","first-page":"2419","article-title":"Important factors mediates the adhesion of Aspergillus fumigatus to alveolar epithelial cells with E-cadherin","volume":"8","author":"Xu","year":"2016","journal-title":"Am J Transl Res"},{"key":"key\n\t\t\t\t20180908093328_CIT0035","doi-asserted-by":"crossref","first-page":"14996","DOI":"10.1039\/C5NR04399A","article-title":"Nanoscale biophysical properties of the cell surface galactosaminogalactan from the fungal pathogen Aspergillus fumigatus","volume":"7","author":"Beaussart","year":"2015","journal-title":"Nanoscale"},{"key":"key\n\t\t\t\t20180908093328_CIT0036","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.FUNK-0035-2016","article-title":"The fungal cell wall: structure, biosynthesis, and function","volume":"5","author":"Gow","year":"2017","journal-title":"Microbiol Spectr"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/218\/8\/1306\/25700118\/jiy298.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T10:44:15Z","timestamp":1571395455000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/218\/8\/1306\/5005025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,28]]},"references-count":36,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,5,28]]},"published-print":{"date-parts":[[2018,9,8]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiy298","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,10,15]]},"published":{"date-parts":[[2018,5,28]]}}}