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However, the relationship between these markers with T-cell function and virus clearance during EVD is poorly understood. To gain biological insight into the role of T cells during EVD, combined transcriptomics and T-cell receptor sequencing was used to profile blood samples from fatal and nonfatal EVD patients from the recent West African EVD epidemic. Fatal EVD was characterized by strong T-cell activation and increased abundance of T-cell inhibitory molecules. However, the early T-cell response was oligoclonal and did not result in viral clearance. In contrast, survivors mounted highly diverse T-cell responses, maintained low levels of T-cell inhibitors, and cleared Ebola virus. Our findings highlight the importance of T-cell immunity in surviving EVD and strengthen the foundation for further research on targeting of the dendritic cell-T cell interface for postexposure immunotherapy.<\/jats:p>","DOI":"10.1093\/infdis\/jiy352","type":"journal-article","created":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T11:07:44Z","timestamp":1528456064000},"page":"S508-S518","source":"Crossref","is-referenced-by-count":38,"title":["T-Cell Receptor Diversity and the Control of T-Cell Homeostasis Mark Ebola Virus Disease Survival in Humans"],"prefix":"10.1093","volume":"218","author":[{"given":"Emily","family":"Speranza","sequence":"first","affiliation":[{"name":"Department of Microbiology, Boston University School of Medicine, Boston MA"},{"name":"Department of Bioinformatics Program, Boston University, Boston MA"},{"name":"Department of National Emerging Infectious Diseases Laboratories, Boston University, Boston MA"},{"name":"Department of Mathematics and Statistics, 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