{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:13:06Z","timestamp":1790716386063,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"suppl_2","license":[{"start":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T00:00:00Z","timestamp":1537574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000296","name":"British Skin Foundation","doi-asserted-by":"publisher","award":["MR\/M003833\/1"],"award-info":[{"award-number":["MR\/M003833\/1"]}],"id":[{"id":"10.13039\/501100000296","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Institute Strategic Programme","award":["BB\/BB\/P013740\/1"],"award-info":[{"award-number":["BB\/BB\/P013740\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,22]]},"DOI":"10.1093\/infdis\/jiy420","type":"journal-article","created":{"date-parts":[[2018,7,14]],"date-time":"2018-07-14T13:29:05Z","timestamp":1531574945000},"page":"S88-S98","source":"Crossref","is-referenced-by-count":16,"title":["Impact of Zostavax Vaccination on T-Cell Accumulation and Cutaneous Gene Expression in the Skin of Older Humans After Varicella Zoster Virus Antigen\u2013Specific Challenge"],"prefix":"10.1093","volume":"218","author":[{"given":"Neil P","family":"Patel","sequence":"first","affiliation":[{"name":"Division of Infection and Immunity, University College London"},{"name":"Department of Dermatology, Royal Free Hospital, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milica","family":"Vukmanovic-Stejic","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, University College London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayte","family":"Suarez- Farinas","sequence":"additional","affiliation":[{"name":"Laboratory for Investigative Dermatology, Rockefeller University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma S","family":"Chambers","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, University College London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Sandhu","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, University College London"},{"name":"Department of Dermatology, Royal Free Hospital, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judilyn","family":"Fuentes-Duculan","sequence":"additional","affiliation":[{"name":"Laboratory for Investigative Dermatology, Rockefeller University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil A","family":"Mabbott","sequence":"additional","affiliation":[{"name":"Roslin Institute, University of Edinburgh, Midlothian, United Kingdom"},{"name":"Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm H A","family":"Rustin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Royal Free Hospital, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Krueger","sequence":"additional","affiliation":[{"name":"Laboratory for Investigative Dermatology, Rockefeller University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne N","family":"Akbar","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, University College London"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,9,22]]},"reference":[{"key":"key\n\t\t\t\t20181003053225_CIT0001","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S1473-3099(02)00437-1","article-title":"Ageing and infection","volume":"2","author":"Gavazzi","year":"2002","journal-title":"Lancet Infect Dis"},{"key":"key\n\t\t\t\t20181003053225_CIT0002","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.1365-2133.2005.06799.x","article-title":"Skin cancer incidence and the ageing population","volume":"153","author":"Diffey","year":"2005","journal-title":"Br J Dermatol"},{"key":"key\n\t\t\t\t20181003053225_CIT0003","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.patbio.2003.09.004","article-title":"Immunity and immunization in elderly","volume":"51","author":"Bour\u00e9e","year":"2003","journal-title":"Pathol Biol (Paris)"},{"key":"key\n\t\t\t\t20181003053225_CIT0004","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.4065\/82.11.1341","article-title":"A population-based study of the incidence and complication rates of herpes zoster before zoster vaccine introduction","volume":"82","author":"Yawn","year":"2007","journal-title":"Mayo Clin Proc"},{"key":"key\n\t\t\t\t20181003053225_CIT0005","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1083-8791(00)70004-8","article-title":"Varicella-Zoster virus: pathogenesis, immunity, and clinical management in hematopoietic cell transplant recipients","volume":"6","author":"Arvin","year":"2000","journal-title":"Biol Blood Marrow Transplant"},{"key":"key\n\t\t\t\t20181003053225_CIT0006","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1002\/jmv.23427","article-title":"Systemic varicella zoster virus reactive effector memory T-cells impaired in the elderly and in kidney transplant recipients","volume":"84","author":"van Besouw","year":"2012","journal-title":"J Med Virol"},{"key":"key\n\t\t\t\t20181003053225_CIT0007","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/tid.12180","article-title":"Varicella zoster reactivation after hematopoietic stem cell transplant in children is strongly correlated with leukemia treatment and suppression of host T-lymphocyte immunity","volume":"16","author":"Vermont","year":"2014","journal-title":"Transpl Infect Dis"},{"key":"key\n\t\t\t\t20181003053225_CIT0008","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1038\/jid.2015.63","article-title":"The characterization of Varicella zoster virus-specific T cells in skin and blood during aging","volume":"135","author":"Vukmanovic-Stejic","year":"2015","journal-title":"J Invest Dermatol"},{"key":"key\n\t\t\t\t20181003053225_CIT0009","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1086\/605611","article-title":"Varicella-zoster virus-specific immune responses to herpes zoster in elderly participants in a trial of a clinically effective zoster vaccine","volume":"200","author":"Weinberg","year":"2009","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20181003053225_CIT0010","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1017\/S0950268812002671","article-title":"Assessment of skin test with varicella-zoster virus antigen for predicting the risk of herpes zoster","volume":"141","author":"Okuno","year":"2013","journal-title":"Epidemiol Infect"},{"key":"key\n\t\t\t\t20181003053225_CIT0011","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jdermsci.2015.05.011","article-title":"VZV skin-test reaction, but not antibody, is an important predictive factor for postherpetic neuralgia","volume":"79","author":"Imoto","year":"2015","journal-title":"J Dermatol Sci"},{"key":"key\n\t\t\t\t20181003053225_CIT0012","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1084\/jem.20090896","article-title":"Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging","volume":"206","author":"Agius","year":"2009","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20181003053225_CIT0013","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1056\/NEJMoa051016","article-title":"A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults","volume":"352","author":"Oxman","year":"2005","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20181003053225_CIT0014","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1093\/infdis\/jiv164","article-title":"Zoster vaccination increases the breadth of CD4+ T cells responsive to Varicella zoster virus","volume":"212","author":"Laing","year":"2015","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20181003053225_CIT0015","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3389\/fimmu.2015.00553","article-title":"Effector and central memory poly-functional CD4(+) and CD8(+) T cells are boosted upon ZOSTAVAX(\u00ae) vaccination","volume":"6","author":"Sei","year":"2015","journal-title":"Front Immunol"},{"key":"key\n\t\t\t\t20181003053225_CIT0016","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrmicro3215","article-title":"Molecular mechanisms of varicella zoster virus pathogenesis","volume":"12","author":"Zerboni","year":"2014","journal-title":"Nat Rev Microbiol"},{"key":"key\n\t\t\t\t20181003053225_CIT0017","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/cei.12107","article-title":"Investigation of the cutaneous response to recall antigen in humans in vivo","volume":"173","author":"Akbar","year":"2013","journal-title":"Clin Exp Immunol"},{"key":"key\n\t\t\t\t20181003053225_CIT0018","article-title":"Enhancement of cutaneous immunity during ageing by blocking p38 MAPkinase induced inflammation","author":"Vukmanovic-Stejic","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"key\n\t\t\t\t20181003053225_CIT0019","doi-asserted-by":"crossref","first-page":"977","DOI":"10.4049\/jimmunol.1201331","article-title":"Varicella Zoster-specific CD4+Foxp3+ T cells accumulate after cutaneous antigen challenge in humans","volume":"190","author":"Vukmanovic-Stejic","year":"2013","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20181003053225_CIT0020","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/1471-2105-6-65","article-title":"\u201cHarshlighting\u201d small blemishes on microarrays","volume":"6","author":"Su\u00e1rez-Fari\u00f1as","year":"2005","journal-title":"BMC Bioinformatics"},{"key":"key\n\t\t\t\t20181003053225_CIT0021","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nbt0604-656b","article-title":"Preprocessing of oligonucleotide array data","volume":"22","author":"Wu","year":"2004","journal-title":"Nat Biotechnol"},{"key":"key\n\t\t\t\t20181003053225_CIT0022","doi-asserted-by":"crossref","first-page":"3845","DOI":"10.1016\/S0264-410X(03)00303-7","article-title":"Enhancement of immunity against VZV by giving live varicella vaccine to the elderly assessed by VZV skin test and IAHA, gpELISA antibody assay","volume":"21","author":"Takahashi","year":"2003","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20181003053225_CIT0023","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1084\/jem.20040178","article-title":"Telomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo","volume":"199","author":"Reed","year":"2004","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20181003053225_CIT0024","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.4049\/jimmunol.1102243","article-title":"Cutting edge: tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection","volume":"187","author":"Teijaro","year":"2011","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20181003053225_CIT0025","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.4049\/jimmunol.1200402","article-title":"Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues","volume":"188","author":"Casey","year":"2012","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20181003053225_CIT0026","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/ni.2744","article-title":"The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin","volume":"14","author":"Mackay","year":"2013","journal-title":"Nat Immunol"},{"key":"key\n\t\t\t\t20181003053225_CIT0027","doi-asserted-by":"crossref","first-page":"604","DOI":"10.4049\/jimmunol.1700290","article-title":"Varicella-Zoster virus-specific cellular immune responses to the live attenuated Zoster vaccine in young and older adults","volume":"199","author":"Weinberg","year":"2017","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20181003053225_CIT0028","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1086\/528696","article-title":"Varicella-zoster virus-specific immune responses in elderly recipients of a herpes zoster vaccine","volume":"197","author":"Levin","year":"2008","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20181003053225_CIT0029","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1172\/JCI119129","article-title":"The biology of PECAM-1","volume":"99","author":"Newman","year":"1997","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20181003053225_CIT0030","first-page":"S13","article-title":"Herpes zoster pathogenesis and cell-mediated immunity and immunosenescence","volume":"109","author":"Oxman","year":"2009","journal-title":"J Am Osteopath Assoc"},{"key":"key\n\t\t\t\t20181003053225_CIT0031","first-page":"161","article-title":"Immunization of the elderly to boost immunity against varicella-zoster virus (VZV) as assessed by VZV skin test reaction","volume":"17","author":"Takahashi","year":"2001","journal-title":"Arch Virol Suppl"},{"key":"key\n\t\t\t\t20181003053225_CIT0032","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1093\/infdis\/166.Supplement_1.S58","article-title":"Immunization of the elderly and patients with collagen vascular diseases with live varicella vaccine and use of varicella skin antigen","volume":"166","author":"Takahashi","year":"1992","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20181003053225_CIT0033","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.4049\/jimmunol.181.3.1835","article-title":"Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation","volume":"181","author":"Lages","year":"2008","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20181003053225_CIT0034","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1056\/NEJMoa1603800","article-title":"Efficacy of the Herpes zoster subunit vaccine in adults 70 years of age or older","volume":"375","author":"Cunningham","year":"2016","journal-title":"N Engl J Med"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/218\/suppl_2\/S88\/25893002\/jiy420.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,20]],"date-time":"2019-10-20T16:58:49Z","timestamp":1571590729000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/218\/suppl_2\/S88\/5105963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,22]]},"references-count":34,"journal-issue":{"issue":"suppl_2","published-online":{"date-parts":[[2018,9,22]]},"published-print":{"date-parts":[[2018,9,22]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiy420","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,11,1]]},"published":{"date-parts":[[2018,9,22]]}}}