{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:47:31Z","timestamp":1790380051332,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2018,9,15]],"date-time":"2018-09-15T00:00:00Z","timestamp":1536969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,29]]},"abstract":"<jats:p>A new paradigm has emerged for treating infections, which focuses on targeting host pathways that are critical for pathogen invasion, survival, and multiplication. We show that ibrutinib, a ITK\/BTK inhibitor, could be host-directed drug for treatment of visceral leishmaniasis.<\/jats:p>","DOI":"10.1093\/infdis\/jiy552","type":"journal-article","created":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T03:37:21Z","timestamp":1536723441000},"page":"599-608","source":"Crossref","is-referenced-by-count":32,"title":["The Potent ITK\/BTK Inhibitor Ibrutinib Is Effective for the Treatment of Experimental Visceral Leishmaniasis Caused by Leishmania donovani"],"prefix":"10.1093","volume":"219","author":[{"given":"Sanjay","family":"Varikuti","sequence":"first","affiliation":[{"name":"Department of Pathology, Ohio State University Medical Center, Ohio State University, Columbus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Volpedo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ohio State University Medical Center, Ohio State University, Columbus"},{"name":"Department of Microbiology, Ohio 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