{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:25:27Z","timestamp":1792794327762,"version":"4.5.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo of Brazil","award":["2014\/18337-4"],"award-info":[{"award-number":["2014\/18337-4"]}],"id":[{"id":"https:\/\/ror.org\/02ddkpn78","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo of Brazil","award":["2018\/07054-2"],"award-info":[{"award-number":["2018\/07054-2"]}],"id":[{"id":"https:\/\/ror.org\/02ddkpn78","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo of Brazil","award":["2014\/50981-0"],"award-info":[{"award-number":["2014\/50981-0"]}],"id":[{"id":"https:\/\/ror.org\/02ddkpn78","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico of Brazil","doi-asserted-by":"crossref","award":["150520\/2017-4"],"award-info":[{"award-number":["150520\/2017-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Alfred \u00d6sterlund Foundation, the Knut and Alice Wallenberg Foundation","award":["KAW 2011.0037"],"award-info":[{"award-number":["KAW 2011.0037"]}],"id":[{"id":"https:\/\/ror.org\/004hzzk67","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007459","name":"Ragnar S\u00f6derberg Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007459","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Medical Faculty of Lund University, the Swedish Foundation","award":["K2014-56X-13413-15-3"],"award-info":[{"award-number":["K2014-56X-13413-15-3"]}],"id":[{"id":"https:\/\/ror.org\/012a77v79","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","award":["2013\u20132438"],"award-info":[{"award-number":["2013\u20132438"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,23]]},"DOI":"10.1093\/infdis\/jiy589","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T15:09:57Z","timestamp":1538838597000},"page":"996-1006","source":"Crossref","is-referenced-by-count":10,"title":["Heparin-Binding Protein Release Is Strongly Induced by\n                    <i>Leptospira<\/i>\n                    Species and Is a Candidate for an Early Diagnostic Marker of Human Leptospirosis"],"prefix":"10.1093","volume":"219","author":[{"given":"M\u00f4nica L","family":"Vieira","sequence":"first","affiliation":[{"name":"Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden"},{"name":"Laborat\u00f3rio Especial de Desenvolvimento de Vacinas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Persson","sequence":"additional","affiliation":[{"name":"Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f4nica","family":"Lopes-Ferreira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Especial de Toxinologia Aplicada, Instituto Butantan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliete C","family":"Romero","sequence":"additional","affiliation":[{"name":"Centro de Bacteriologia, Instituto Adolfo Lutz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Kirchgatter","sequence":"additional","affiliation":[{"name":"Nucleo de Estudos em Mal\u00e1ria, Superintend\u00eancia de Controle de Endemias, Instituto de Medicina Tropical de S\u00e3o Paulo, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Lucia T O","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Especial de Desenvolvimento de Vacinas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Herwald","sequence":"additional","affiliation":[{"name":"Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,10,8]]},"reference":[{"key":"key\n\t\t\t\t2019031513364064600_CIT0001","first-page":"259","volume-title":"Leptospira and Leptospirosis","author":"Faine","year":"1999","edition":"2"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0002","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1128\/CMR.14.2.296-326.2001","article-title":"Leptospirosis","volume":"14","author":"Levett","year":"2001","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0003","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/00001432-200110000-00005","article-title":"Leptospirosis","volume":"14","author":"Vinetz","year":"2001","journal-title":"Curr Opin Infect Dis"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0004","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1586\/eri.10.151","article-title":"Diagnosis of acute leptospirosis","volume":"9","author":"Toyokawa","year":"2011","journal-title":"Expert Rev Anti Infect Ther"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0005","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nsb0497-265","article-title":"Structure of HBP, a multifunctional protein with a serine proteinase fold","volume":"4","author":"Iversen","year":"1997","journal-title":"Nat Struct Biol"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0006","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1182\/blood.V99.5.1785","article-title":"Secretion of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesicles","volume":"99","author":"Tapper","year":"2002","journal-title":"Blood"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0007","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/nm1001-1123","article-title":"Heparin-binding protein (HBP\/CAP37): a missing link in neutrophil-evoked alteration of vascular permeability","volume":"7","author":"Gautam","year":"2001","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0008","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0014-5793(96)00639-4","article-title":"Characterization of recombinant human HBP\/CAP37\/azurocidin, a pleiotropic mediator of inflammation-enhancing LPS-induced cytokine release from monocytes","volume":"390","author":"Rasmussen","year":"1996","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0009","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1172\/JCI114593","article-title":"CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity","volume":"85","author":"Pereira","year":"1990","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0010","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1159\/000314853","article-title":"Roles of heparin-binding protein in bacterial infections","volume":"2","author":"Linder","year":"2010","journal-title":"J Innate Immun"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0011","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1023\/A:1022398027143","article-title":"Heparin binding protein (CAP37) is an opsonin for Staphylococcus aureus and increases phagocytosis in monocytes","volume":"22","author":"Heinzelmann","year":"1998","journal-title":"Inflammation"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0012","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1074\/jbc.271.6.2935","article-title":"Identification of defensin-1, defensin-2, and CAP37\/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils","volume":"271","author":"Chertov","year":"1996","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0013","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/jlb.51.4.316","article-title":"A neutrophil-derived proteolytic inactive elastase homologue (hHBP) mediates reversible contraction of fibroblasts and endothelial cell monolayers and stimulates monocyte survival and thrombospondin secretion","volume":"51","author":"Ostergaard","year":"1992","journal-title":"J Leukoc Biol"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0014","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0092-8674(04)00057-1","article-title":"M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage","volume":"116","author":"Herwald","year":"2004","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0015","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1160\/TH03-12-0732","article-title":"Heparin binding protein is increased in chronic leg ulcer fluid and released from granulocytes by secreted products of Pseudomonas aeruginosa","volume":"92","author":"Lundqvist","year":"2004","journal-title":"Thromb Haemost"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0016","doi-asserted-by":"crossref","first-page":"21288","DOI":"10.1038\/srep21288","article-title":"Differential neutrophil responses to bacterial stimuli: Streptococcal strains are potent inducers of heparin-binding protein and resistin-release","volume":"6","author":"Sn\u00e4ll","year":"2016","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0017","doi-asserted-by":"crossref","first-page":"29373","DOI":"10.1038\/srep29373","article-title":"Phenol-soluble modulin \u03b14 mediates Staphylococcus aureus-associated vascular leakage by stimulating heparin-binding protein release from neutrophils","volume":"6","author":"Li","year":"2016","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0018","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1097\/CCM.0b013e318206c396","article-title":"Heparin-binding protein: a diagnostic marker of acute bacterial meningitis","volume":"39","author":"Linder","year":"2011","journal-title":"Crit Care Med"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0019","doi-asserted-by":"crossref","first-page":"R90","DOI":"10.1186\/cc11353","article-title":"Elevated plasma levels of heparin-binding protein in intensive care unit patients with severe sepsis and septic shock","volume":"16","author":"Linder","year":"2012","journal-title":"Crit Care"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0020","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1086\/605563","article-title":"Heparin-binding protein: an early marker of circulatory failure in sepsis","volume":"49","author":"Linder","year":"2009","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0021","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/jid.2009.437","article-title":"Erysipelas caused by group A streptococcus activates the contact system and induces the release of heparin-binding protein","volume":"130","author":"Linder","year":"2010","journal-title":"J Invest Dermatol"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0022","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/s00467-012-2132-x","article-title":"Elevated urine levels of heparin-binding protein in children with urinary tract infection","volume":"27","author":"Kj\u00f6lvmark","year":"2012","journal-title":"Pediatr Nephrol"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0023","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/joim.12604","article-title":"Heparin-binding protein: a key player in the pathophysiology of organ dysfunction in sepsis","volume":"281","author":"Fisher","year":"2017","journal-title":"J Intern Med"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0024","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/jlb.66.4.634","article-title":"Characterization of the biosynthesis, processing, and sorting of human HBP\/CAP37\/azurocidin","volume":"66","author":"Lindmark","year":"1999","journal-title":"J Leukoc Biol"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0025","doi-asserted-by":"crossref","first-page":"e0004713","DOI":"10.1371\/journal.pntd.0004713","article-title":"Modulation of Hemostatic and Inflammatory Responses by Leptospira Spp","volume":"10","author":"Vieira","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0026","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1080\/21505594.2017.1407484","article-title":"Leptospira interrogans outer membrane protein LipL21 is a potent inhibitor of neutrophil myeloperoxidase","volume":"9","author":"Vieira","year":"2018","journal-title":"Virulence"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0027","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jinf.2009.10.047","article-title":"Lsa63, a newly identified surface protein of Leptospira interrogans binds laminin and collagen IV","volume":"60","author":"Vieira","year":"2010","journal-title":"J Infect"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0028","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.toxicon.2014.05.014","article-title":"Anti-inflammatory effect of Natterins, the major toxins from the Thalassophryne nattereri fish venom is dependent on TLR4\/MyD88\/PI3K signaling pathway","volume":"87","author":"Ferreira","year":"2014","journal-title":"Toxicon"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0029","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/00062752-200301000-00005","article-title":"Neutrophil transendothelial migration and alteration in vascular permeability: focus on neutrophil-derived azurocidin","volume":"10","author":"Edens","year":"2003","journal-title":"Curr Opin Hematol"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0030","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1006\/geno.1997.4896","article-title":"Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans","volume":"45","author":"Cowland","year":"1997","journal-title":"Genomics"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0031","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0009-8981(73)90174-5","article-title":"A colorimetric assay for serum lactate dehydrogenase","volume":"46","author":"Burd","year":"1973","journal-title":"Clin Chim Acta"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0032","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1710-1492-2-3-98","article-title":"Mechanisms of degranulation in neutrophils","volume":"2","author":"Lacy","year":"2006","journal-title":"Allergy Asthma Clin Immunol"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0033","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1183\/09031936.00173207","article-title":"Neutrophil degranulation mediates severe lung damage triggered by streptococcal M1 protein","volume":"32","author":"Soehnlein","year":"2008","journal-title":"Eur Respir J"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0034","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.4049\/jimmunol.177.2.1221","article-title":"Streptococcal M protein: a multipotent and powerful inducer of inflammation","volume":"177","author":"P\u00e5hlman","year":"2006","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0035","first-page":"579","article-title":"Neutrophil counts in leptospirosis patients infected with different serovars","volume":"30","author":"Craig","year":"2013","journal-title":"Trop Biomed"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0036","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1179\/136485909X435058","article-title":"Haematological and clinical-chemistry markers in patients presenting with leptospirosis: a comparison of the findings from uncomplicated cases with those seen in the severe disease","volume":"103","author":"Craig","year":"2009","journal-title":"Ann Trop Med Parasitol"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0037","doi-asserted-by":"crossref","first-page":"e0165716","DOI":"10.1371\/journal.pone.0165716","article-title":"Major neutrophilia observed in acute phase of human leptospirosis is not associated with increased expression of granulocyte cell activation markers","volume":"11","author":"Raffray","year":"2016","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0038","doi-asserted-by":"crossref","first-page":"e0181014","DOI":"10.1371\/journal.pone.0181014","article-title":"Mononuclear-macrophages but not neutrophils act as major infiltrating anti-leptospiral phagocytes during leptospirosis","volume":"12","author":"Chen","year":"2017","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0039","doi-asserted-by":"crossref","first-page":"e0003927","DOI":"10.1371\/journal.pntd.0003927","article-title":"Neutrophil extracellular traps are involved in the innate immune response to infection with leptospira","volume":"9","author":"Scharrig","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0040","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1096\/fj.08-121277","article-title":"Leukotriene B4-induced changes in vascular permeability are mediated by neutrophil release of heparin-binding protein (HBP\/CAP37\/azurocidin)","volume":"23","author":"Di Gennaro","year":"2009","journal-title":"FASEB J"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0041","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1160\/TH05-08-0572","article-title":"Activation of human polymorphonuclear neutrophils by streptolysin O from Streptococcus pyogenes leads to the release of proinflammatory mediators","volume":"95","author":"Nilsson","year":"2006","journal-title":"Thromb Haemost"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0042","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1128\/IAI.70.1.323-334.2002","article-title":"Novel 45-kilodalton leptospiral protein that is processed to a 31-kilodalton growth-phase-regulated peripheral membrane protein","volume":"70","author":"Matsunaga","year":"2002","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0043","doi-asserted-by":"crossref","first-page":"4092","DOI":"10.1128\/IAI.00353-09","article-title":"Plasminogen acquisition and activation at the surface of leptospira species lead to fibronectin degradation","volume":"77","author":"Vieira","year":"2009","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0044","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3109\/1040841X.2014.972336","article-title":"Interaction of spirochetes with the host fibrinolytic system and potential roles in pathogenesis","volume":"42","author":"Vieira","year":"2016","journal-title":"Crit Rev Microbiol"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0045","doi-asserted-by":"crossref","first-page":"758513","DOI":"10.1155\/2012\/758513","article-title":"Plasminogen binding proteins and plasmin generation on the surface of Leptospira spp.: the contribution to the bacteria-host interactions","volume":"2012","author":"Vieira","year":"2012","journal-title":"J Biomed Biotechnol"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0046","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.it.2009.07.012","article-title":"Opening the flood-gates: how neutrophil-endothelial interactions regulate permeability","volume":"30","author":"DiStasi","year":"2009","journal-title":"Trends Immunol"},{"key":"key\n\t\t\t\t2019031513364064600_CIT0047","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/QCO.0b013e32814a5729","article-title":"Leptospirosis: pathogenesis, immunity, and diagnosis","volume":"20","author":"Palaniappan","year":"2007","journal-title":"Curr Opin Infect Dis"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/219\/6\/996\/28080094\/jiy589.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:51:39Z","timestamp":1605142299000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/219\/6\/996\/5123686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,8]]},"references-count":47,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,10,8]]},"published-print":{"date-parts":[[2019,2,23]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiy589","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,3,15]]},"published":{"date-parts":[[2018,10,8]]}}}