{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T15:10:23Z","timestamp":1773501023953,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T00:00:00Z","timestamp":1574294400000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000185","name":"Defense Advanced Research Projects Agency","doi-asserted-by":"publisher","award":["W911NF-13-1-0346"],"award-info":[{"award-number":["W911NF-13-1-0346"]}],"id":[{"id":"10.13039\/100000185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1-TR001453"],"award-info":[{"award-number":["UL1-TR001453"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1-TR001453"],"award-info":[{"award-number":["UL1-TR001453"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institutes of Health Emerging Infectious Disease Training Grant","award":["T32-AI055400"],"award-info":[{"award-number":["T32-AI055400"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We recently developed anti-OspA human immunoglobulin G1 monoclonal antibodies (HuMAbs) that are effective in preventing Borrelia transmission from ticks in a murine model. Here, we investigated a novel approach of DNA-mediated gene transfer of HuMAbs that provide protection against Lyme disease. Plasmid DNA-encoded anti-OspA HuMAbs inoculated in mice achieved a serum antibody concentration of &amp;gt;6 \u03bcg\/mL. Among mice injected with DNA-encoded monoclonal antibodies, 75%\u201377% were protected against an acute challenge by Borrelia-infected ticks. Our results represent the first demonstration of employing DNA transfer as a delivery system for antibodies that block transmission of Borrelia in animal models.<\/jats:p>","DOI":"10.1093\/infdis\/jiy627","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T20:57:22Z","timestamp":1542315442000},"page":"1146-1150","source":"Crossref","is-referenced-by-count":16,"title":["Anti-OspA DNA-Encoded Monoclonal Antibody Prevents Transmission of Spirochetes in Tick Challenge Providing Sterilizing Immunity in Mice"],"prefix":"10.1093","volume":"219","author":[{"given":"Yang","family":"Wang","sequence":"first","affiliation":[{"name":"MassBiologics of University of Massachusetts Medical School, Boston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rianne","family":"Esquivel","sequence":"first","affiliation":[{"name":"Vaccine and Immunotherapy Center, Wistar Institute, Philadelphia, 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