{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T07:23:14Z","timestamp":1793431394072,"version":"4.5.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"the Medical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000278","name":"Department for International Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000278","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001713","name":"European and Developing Countries Clinical Trials Partnership","doi-asserted-by":"publisher","award":["106325\/Z\/14\/A"],"award-info":[{"award-number":["106325\/Z\/14\/A"]}],"id":[{"id":"10.13039\/501100001713","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Commission Horizon 2020","award":["666085)"],"award-info":[{"award-number":["666085)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,8]]},"DOI":"10.1093\/infdis\/jiy639","type":"journal-article","created":{"date-parts":[[2018,11,4]],"date-time":"2018-11-04T15:06:48Z","timestamp":1541344008000},"page":"1187-1197","source":"Crossref","is-referenced-by-count":81,"title":["Safety and Immunogenicity of a Heterologous Prime-Boost Ebola Virus Vaccine Regimen in Healthy Adults in the United Kingdom and Senegal"],"prefix":"10.1093","volume":"219","author":[{"given":"Navin","family":"Venkatraman","sequence":"first","affiliation":[{"name":"Jenner Institute, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birahim Pierre","family":"Ndiaye","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire le Dantec, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Bowyer","sequence":"additional","affiliation":[{"name":"Jenner Institute, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djibril","family":"Wade","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire le Dantec, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saranya","family":"Sridhar","sequence":"additional","affiliation":[{"name":"Jenner Institute, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Wright","sequence":"additional","affiliation":[{"name":"Jenner Institute, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Powlson","sequence":"additional","affiliation":[{"name":"Jenner Institute, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahima","family":"Ndiaye","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire le Dantec, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siry","family":"Di\u00e8ye","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire le Dantec, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Thompson","sequence":"additional","affiliation":[{"name":"Jenner Institute, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momar","family":"Bakhoum","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire le Dantec, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Morter","sequence":"additional","affiliation":[{"name":"Jenner Institute, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Capone","sequence":"additional","affiliation":[{"name":"ReiThera Srl, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariarosaria","family":"Del Sorbo","sequence":"additional","affiliation":[{"name":"ReiThera Srl, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Jamieson","sequence":"additional","affiliation":[{"name":"Jenner Institute, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommy","family":"Rampling","sequence":"additional","affiliation":[{"name":"Jenner Institute, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehreen","family":"Datoo","sequence":"additional","affiliation":[{"name":"Jenner Institute, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Roberts","sequence":"additional","affiliation":[{"name":"Jenner Institute, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Poulton","sequence":"additional","affiliation":[{"name":"Jenner Institute, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Jenner Institute, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W Ripley","family":"Ballou","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Biologicals, Rixensart, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Roman","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Biologicals, Rixensart, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J M","family":"Lewis","sequence":"additional","affiliation":[{"name":"National Institute for Health Research\/Imperial Clinical Research Facility, Hammersmith Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Lawrie","sequence":"additional","affiliation":[{"name":"Jenner Institute, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egeruan","family":"Imoukhuede","sequence":"additional","affiliation":[{"name":"Jenner Institute, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah C","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Jenner Institute, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tandakha N","family":"Dieye","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire le Dantec, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9827-9836","authenticated-orcid":false,"given":"Katie J","family":"Ewer","sequence":"additional","affiliation":[{"name":"Jenner Institute, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souleymane","family":"Mboup","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire le Dantec, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian V S","family":"Hill","sequence":"additional","affiliation":[{"name":"Jenner Institute, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,11,8]]},"reference":[{"key":"key\n\t\t\t\t2019040805040959500_CIT0001","first-page":"7","volume-title":"Blueprint for R&D preparedness and response to public health emergencies due to highly infectious pathogens","author":"World Health Organization","year":"2015"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0002","doi-asserted-by":"crossref","first-page":"5454","DOI":"10.1016\/j.vaccine.2017.07.054","article-title":"Vaccines against Ebola virus","volume":"36","author":"Venkatraman","year":"2018","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0003","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1056\/NEJMoa1502924","article-title":"Phase 1 trials of rVSV Ebola vaccine in Africa and Europe","volume":"374","author":"Agnandji","year":"2016","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0004","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0140-6736(15)61117-5","article-title":"Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial","volume":"386","author":"Henao-Restrepo","year":"2015","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0005","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0140-6736(14)62385-0","article-title":"Safety and immunogenicity of Ebola virus and Marburg virus glycoprotein DNA vaccines assessed separately and concomitantly in healthy Ugandan adults: a phase 1b, randomised, double-blind, placebo-controlled clinical trial","volume":"385","author":"Kibuuka","year":"2015","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0006","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1056\/NEJMoa1410863","article-title":"Chimpanzee adenovirus vector Ebola vaccine","volume":"376","author":"Ledgerwood","year":"2017","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0007","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1056\/NEJMoa1411627","article-title":"A monovalent chimpanzee adenovirus Ebola vaccine boosted with MVA","volume":"374","author":"Ewer","year":"2016","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0008","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1056\/NEJMoa1414216","article-title":"A recombinant vesicular stomatitis virus Ebola vaccine","volume":"376","author":"Regules","year":"2017","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0009","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/infdis\/jiu511","article-title":"Safety and immunogenicity of DNA vaccines encoding Ebolavirus and Marburgvirus wild-type glycoproteins in a phase I clinical trial","volume":"211","author":"Sarwar","year":"2015","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0010","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1473-3099(15)00362-X","article-title":"Use of ChAd3-EBO-Z Ebola virus vaccine in Malian and US adults, and boosting of Malian adults with MVA-BN-Filo: a phase 1, single-blind, randomised trial, a phase 1b, open-label and double-blind, dose-escalation trial, and a nested, randomised, double-blind, placebo-controlled trial","volume":"16","author":"Tapia","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0011","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1016\/S0140-6736(15)60553-0","article-title":"Safety and immunogenicity of a novel recombinant adenovirus type-5 vector-based Ebola vaccine in healthy adults in China: preliminary report of a randomised, double-blind, placebo-controlled, phase 1 trial","volume":"385","author":"Zhu","year":"2015","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0012","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0140-6736(16)32621-6","article-title":"Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola \u00c7a Suffit!)","volume":"389","author":"Henao-Restrepo","year":"2017","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0013","volume-title":"Report of the SAGE Working Group on Ebola Vaccines and Vaccination with provisional recommendations for vaccination","author":"World Health Organization","year":"2015"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0014","doi-asserted-by":"crossref","first-page":"115ra2","DOI":"10.1126\/scitranslmed.3002925","article-title":"Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species","volume":"4","author":"Colloca","year":"2012","journal-title":"Sci Transl Med"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0015","doi-asserted-by":"crossref","first-page":"115ra1","DOI":"10.1126\/scitranslmed.3003155","article-title":"Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man","volume":"4","author":"Barnes","year":"2012","journal-title":"Sci Transl Med"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0016","doi-asserted-by":"crossref","first-page":"7283","DOI":"10.1016\/j.vaccine.2015.10.111","article-title":"Analysis of T cell responses to chimpanzee adenovirus vectors encoding HIV gag-pol-nef antigen","volume":"33","author":"Herath","year":"2015","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0017","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1473-3099(15)00486-7","article-title":"Safety and immunogenicity of a chimpanzee adenovirus-vectored Ebola vaccine in healthy adults: a randomised, double-blind, placebo-controlled, dose-finding, phase 1\/2a study","volume":"16","author":"De Santis","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0018","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/nm.3702","article-title":"Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge","volume":"20","author":"Stanley","year":"2014","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0019","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/nm.2447","article-title":"CD8+ cellular immunity mediates rAd5 vaccine protection against Ebola virus infection of nonhuman primates","volume":"17","author":"Sullivan","year":"2011","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0020","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ebiom.2017.03.045","article-title":"Dose-dependent T-cell dynamics and cytokine cascade following rVSV-ZEBOV immunization","volume":"19","author":"Dahlke","year":"2017","journal-title":"EBioMedicine"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0021","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1080\/14760584.2016.1187566","article-title":"Ebola virus disease candidate vaccines under evaluation in clinical trials","volume":"15","author":"Martins","year":"2016","journal-title":"Expert Rev Vaccines"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0022","author":"ClinicalTrials.gov"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0023","doi-asserted-by":"crossref","first-page":"300ra126","DOI":"10.1126\/scitranslmed.aac5745","article-title":"Chimpanzee adenovirus- and MVA-vectored respiratory syncytial virus vaccine is safe and immunogenic in adults","volume":"7","author":"Green","year":"2015","journal-title":"Sci Transl Med"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0024","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.virusres.2005.03.028","article-title":"Complete genome sequence of an Ebola virus (Sudan species) responsible for a 2000 outbreak of human disease in Uganda","volume":"113","author":"Sanchez","year":"2005","journal-title":"Virus Res"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0025","first-page":"287","article-title":"Comprehensive characterization of cellular immune responses following Ebola virus infection","volume":"215","author":"Dahlke","year":"2017","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0026","doi-asserted-by":"crossref","first-page":"e38153","DOI":"10.1371\/journal.pone.0038153","article-title":"Low immune response to hepatitis B vaccine among children in Dakar, Senegal","volume":"7","author":"Rey-Cuille","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0027","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2014.0141","article-title":"Malnutrition and vaccination in developing countries","volume":"370","author":"Prendergast","year":"2015","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"key\n\t\t\t\t2019040805040959500_CIT0028","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1093\/cid\/cit373","article-title":"Characterizing vaccine responses using host genomic and transcriptomic analysis","volume":"57","author":"O\u2019Connor","year":"2013","journal-title":"Clin Infect Dis"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/219\/8\/1187\/28261161\/jiy639.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T12:12:21Z","timestamp":1572523941000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/219\/8\/1187\/5164386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,8]]},"references-count":28,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,11,8]]},"published-print":{"date-parts":[[2019,4,8]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiy639","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,4,15]]},"published":{"date-parts":[[2018,11,8]]}}}