{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:50:43Z","timestamp":1788371443740,"version":"build-2803163510"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T00:00:00Z","timestamp":1544140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["N01-AI-30025"],"award-info":[{"award-number":["N01-AI-30025"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["N01-AI-65306"],"award-info":[{"award-number":["N01-AI-65306"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["N01-AI-15113"],"award-info":[{"award-number":["N01-AI-15113"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["N01-AI-62554"],"award-info":[{"award-number":["N01-AI-62554"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Viral loads (VLs) frequently are followed during treatment of symptomatic congenital cytomegalovirus disease, but their predictive value is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Post hoc analysis of 2 antiviral studies was performed. Seventy-three subjects were treated for 6 weeks and 47 subjects were treated for 6 months. Whole blood VL was determined by real-time polymerase chain reaction before and during therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher baseline VL was associated with central nervous system involvement (3.82 log, range 1\u20135.65 vs 3.32 log, range 1\u20135.36; P = .001), thrombocytopenia (3.68 log, range 1\u20135.65 vs 3.43 log, range 1\u20135.36; P = .03), and transaminitis at presentation (3.73 log, range 1\u20135.60 vs 3.39 log, range 1\u20135.65; P = .009), but with overlap in the amount of virus detected between groups. In subjects treated for 6 months, lower VL at presentation correlated with better hearing outcomes at 12 months, but VL breakpoints predictive of hearing loss were not identified. Sustained viral suppression during 6 months of therapy correlated with better hearing outcomes at 6, 12, and 24 months (P = .01, P = .0007, P = .04), but a majority without viral suppression still had improved hearing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In infants with symptomatic congenital cytomegalovirus disease, higher whole blood VL before initiation of antiviral therapy has no clinically meaningful predictive value for long-term outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1093\/infdis\/jiy695","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T12:13:36Z","timestamp":1543839216000},"page":"1398-1406","source":"Crossref","is-referenced-by-count":51,"title":["Blood Viral Load in Symptomatic Congenital Cytomegalovirus Infection"],"prefix":"10.1093","volume":"219","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5258-9417","authenticated-orcid":false,"given":"Concetta","family":"Marsico","sequence":"first","affiliation":[{"name":"Neonatology Unit, Department of Medical and Surgical Sciences, University of Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Immaculada","family":"Aban","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Division of Infectious Diseases, University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huichien","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Division of Infectious Diseases, University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott H","family":"James","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Infectious Diseases, University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo J","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Divisions of Pediatric Infectious Diseases and Neonatology, Nationwide Children\u2019s Hospital - Ohio State University College of Medicine, Columbus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Carolinas Medical Center, Charlotte, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravit","family":"Arav-Boger","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin, Milwaukee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian G","family":"Michaels","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Pittsburgh of UPMC, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar","family":"Ashouri","sequence":"additional","affiliation":[{"name":"Infectious Diseases, CHOC Children\u2019s Hospital, Orange, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet A","family":"Englund","sequence":"additional","affiliation":[{"name":"University of Washington\/Seattle Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Estrada","sequence":"additional","affiliation":[{"name":"University of South Alabama, Mobile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard F","family":"Jacobs","sequence":"additional","affiliation":[{"name":"University of Arkansas, Little Rock"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 R","family":"Romero","sequence":"additional","affiliation":[{"name":"University of Arkansas, Little Rock"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil K","family":"Sood","sequence":"additional","affiliation":[{"name":"Steven and Alexandra Cohen Children\u2019s Medical Center, New Hyde Park, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Whitworth","sequence":"additional","affiliation":[{"name":"Cook Children\u2019s Medical Center, Fort Worth, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope M","family":"Jester","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Infectious Diseases, University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J","family":"Whitley","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Infectious Diseases, University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David 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