{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:23:22Z","timestamp":1787009002750,"version":"build-2736575974"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T00:00:00Z","timestamp":1548892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,8]]},"DOI":"10.1093\/infdis\/jiy703","type":"journal-article","created":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T23:08:19Z","timestamp":1546384099000},"page":"S81-S87","source":"Crossref","is-referenced-by-count":14,"title":["How Live Attenuated Vaccines Can Inform the Development of Broadly Cross-Protective Influenza Vaccines"],"prefix":"10.1093","volume":"219","author":[{"given":"Rajeev","family":"Rudraraju","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Melbourne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Mordant","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Melbourne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanta","family":"Subbarao","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Melbourne"},{"name":"World Health Organization Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,4,8]]},"reference":[{"key":"key\n\t\t\t\t2019040805025343900_CIT0001","first-page":"181","article-title":"Live attenuated influenza vaccine","volume":"386","author":"Jin","year":"2015","journal-title":"Curr Top Microbiol Immunol"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0002","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1097\/00019048-199305000-00003","article-title":"Use of live attenuated cold-adapted influenza A reassortant virus vaccines in infants, children, young adults and elderly adults","volume":"2","author":"Murphy","year":"1993","journal-title":"Infect Dis Clin Pract"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0003","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1089\/08828240260066242","article-title":"Principles underlying the development and use of live attenuated cold-adapted influenza A and B virus vaccines","volume":"15","author":"Murphy","year":"2002","journal-title":"Viral Immunol"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0004","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/0264-410X(86)90049-6","article-title":"Study of live recombinant cold-adapted influenza bivalent vaccine of type A for use in children: an epidemiological control trial","volume":"4","author":"Alexandrova","year":"1986","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0005","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1099\/vir.0.017996-0","article-title":"PB2 and PA genes control the expression of the temperature-sensitive phenotype of cold-adapted B\/USSR\/60\/69 influenza master donor virus","volume":"91","author":"Kiseleva","year":"2010","journal-title":"J Gen Virol"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0006","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.virol.2005.10.005","article-title":"Genetic mapping of the cold-adapted phenotype of B\/Ann Arbor\/1\/66, the master donor virus for live attenuated influenza vaccines (FluMist)","volume":"345","author":"Chen","year":"2006","journal-title":"Virology"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0007","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0042-6822(02)00035-1","article-title":"Multiple amino acid residues confer temperature sensitivity to human influenza virus vaccine strains (FluMist) derived from cold-adapted A\/Ann Arbor\/6\/60","volume":"306","author":"Jin","year":"2003","journal-title":"Virology"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0008","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/0042-6822(92)90050-Y","article-title":"Sequence changes in the live attenuated, cold-adapted variants of influenza A\/Leningrad\/134\/57 (H2N2) virus","volume":"186","author":"Klimov","year":"1992","journal-title":"Virology"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0009","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1016\/j.vaccine.2005.11.007","article-title":"Genetic stability of live, cold-adapted influenza virus components of the FluMist\/CAIV-T vaccine throughout the manufacturing process","volume":"24","author":"Buonagurio","year":"2006","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0010","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.virol.2005.11.006","article-title":"Genetic and phenotypic stability of cold-adapted influenza viruses in a trivalent vaccine administered to children in a day care setting","volume":"347","author":"Buonagurio","year":"2006","journal-title":"Virology"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0011","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1128\/JCM.38.2.839-845.2000","article-title":"Genotypic stability of cold-adapted influenza virus vaccine in an efficacy clinical trial","volume":"38","author":"Cha","year":"2000","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0012","doi-asserted-by":"crossref","first-page":"7008","DOI":"10.1016\/j.vaccine.2015.09.050","article-title":"Genetic stability of live attenuated vaccines against potentially pandemic influenza viruses","volume":"33","author":"Kiseleva","year":"2015","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0013","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1093\/infdis\/jir661","article-title":"Influenza hemagglutination-inhibition antibody titer as a correlate of vaccine-induced protection","volume":"204","author":"Ohmit","year":"2011","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0014","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/B978-0-12-415847-4.00059-8","article-title":"Respiratory virus vaccines","volume-title":"Mucosal immunology","author":"Broadbent","year":"2015","edition":"4"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0015","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1128\/JCM.23.1.73-76.1986","article-title":"Resistance of adults to challenge with influenza A wild-type virus after receiving live or inactivated virus vaccine","volume":"23","author":"Clements","year":"1986","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0016","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/0264-410X(95)00016-T","article-title":"Human immune responses to influenza virus vaccines administered by systemic or mucosal routes","volume":"13","author":"Moldoveanu","year":"1995","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0017","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1586\/erv.11.73","article-title":"Protective efficacy of live-attenuated influenza vaccine (multivalent, Ann Arbor strain): a literature review addressing interference","volume":"10","author":"Bandell","year":"2011","journal-title":"Expert Rev Vaccines"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0018","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1128\/JCM.24.1.157-160.1986","article-title":"Serum and nasal wash antibodies associated with resistance to experimental challenge with influenza A wild-type virus","volume":"24","author":"Clements","year":"1986","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0019","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1086\/315323","article-title":"Correlates of immune protection induced by live, attenuated, cold-adapted, trivalent, intranasal influenza virus vaccine","volume":"181","author":"Belshe","year":"2000","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0020","first-page":"488","article-title":"Influenza vaccine-live","volume-title":"Plotkin\u2019s vaccines","author":"Luke","year":"2017","edition":"7"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0021","doi-asserted-by":"crossref","first-page":"6794","DOI":"10.1016\/j.vaccine.2012.09.018","article-title":"The role of nasal IgA in children vaccinated with live attenuated influenza vaccine","volume":"30","author":"Ambrose","year":"2012","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0022","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1073\/pnas.1009908108","article-title":"Seasonal influenza infection and live vaccine prime for a response to the 2009 pandemic H1N1 vaccine","volume":"108","author":"Chen","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0023","doi-asserted-by":"crossref","first-page":"e4436","DOI":"10.1371\/journal.pone.0004436","article-title":"H5N1 vaccine-specific B cell responses in ferrets primed with live attenuated seasonal influenza vaccines","volume":"4","author":"Cheng","year":"2009","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0024","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1128\/JVI.01564-10","article-title":"The magnitude of local immunity in the lungs of mice induced by live attenuated influenza vaccines is determined by local viral replication and induction of cytokines","volume":"85","author":"Lau","year":"2011","journal-title":"J Virol"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0025","doi-asserted-by":"crossref","first-page":"5089","DOI":"10.1128\/JVI.07205-11","article-title":"The contribution of systemic and pulmonary immune effectors to vaccine-induced protection from H5N1 influenza virus infection","volume":"86","author":"Lau","year":"2012","journal-title":"J Virol"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0026","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0022-3476(00)70097-7","article-title":"Efficacy of vaccination with live attenuated, cold-adapted, trivalent, intranasal influenza virus vaccine against a variant (A\/Sydney) not contained in the vaccine","volume":"136","author":"Belshe","year":"2000","journal-title":"J Pediatr"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0027","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1097\/01.inf.0000143643.44463.b1","article-title":"Live attenuated influenza vaccine induces cross-reactive antibody responses in children against an a\/Fujian\/411\/2002-like H3N2 antigenic variant strain","volume":"23","author":"Mendelman","year":"2004","journal-title":"Pediatr Infect Dis J"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0028","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1056\/NEJMoa0808652","article-title":"Comparative efficacy of inactivated and live attenuated influenza vaccines","volume":"361","author":"Monto","year":"2009","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0029","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1056\/NEJMoa061850","article-title":"Prevention of antigenically drifted influenza by inactivated and live attenuated vaccines","volume":"355","author":"Ohmit","year":"2006","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0030","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1128\/JVI.01829-13","article-title":"Evaluation of three live attenuated H2 pandemic influenza vaccine candidates in mice and ferrets","volume":"88","author":"Chen","year":"2014","journal-title":"J Virol"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0031","doi-asserted-by":"crossref","first-page":"4430","DOI":"10.1016\/S0264-410X(03)00430-4","article-title":"Generation and characterization of a cold-adapted influenza A H9N2 reassortant as a live pandemic influenza virus vaccine candidate","volume":"21","author":"Chen","year":"2003","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0032","doi-asserted-by":"crossref","first-page":"7016","DOI":"10.1128\/JVI.00100-14","article-title":"Development of a high-yield live attenuated H7N9 influenza virus vaccine that provides protection against homologous and heterologous H7 wild-type viruses in ferrets","volume":"88","author":"Chen","year":"2014","journal-title":"J Virol"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0033","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.virol.2008.05.021","article-title":"A live attenuated cold-adapted influenza A H7N3 virus vaccine provides protection against homologous and heterologous H7 viruses in mice and ferrets","volume":"378","author":"Joseph","year":"2008","journal-title":"Virology"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0034","doi-asserted-by":"crossref","first-page":"11950","DOI":"10.1128\/JVI.01305-10","article-title":"A live attenuated H7N7 candidate vaccine virus induces neutralizing antibody that confers protection from challenge in mice, ferrets, and monkeys","volume":"84","author":"Min","year":"2010","journal-title":"J Virol"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0035","article-title":"Live, attenuated influenza A H5N1 candidate vaccines provide broad cross-protection in mice and ferrets","volume":"3:1541\u201355","author":"Suguitan","year":"2006","journal-title":"PLoS Med"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0036","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1006\/viro.2002.1742","article-title":"Evaluation of a genetically modified reassortant H5N1 influenza A virus vaccine candidate generated by plasmid-based reverse genetics","volume":"305","author":"Subbarao","year":"2003","journal-title":"Virology"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0037","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.vaccine.2014.10.065","article-title":"Replication of live attenuated cold-adapted H2N2 influenza virus vaccine candidates in non human primates","volume":"33","author":"Broadbent","year":"2015","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0038","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1128\/JVI.01775-08","article-title":"Evaluation of live attenuated influenza a virus h6 vaccines in mice and ferrets","volume":"83","author":"Chen","year":"2009","journal-title":"J Virol"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0039","doi-asserted-by":"crossref","first-page":"8139","DOI":"10.1128\/JVI.00425-14","article-title":"African green monkeys recapitulate the clinical experience with replication of live attenuated pandemic influenza virus vaccine candidates","volume":"88","author":"Matsuoka","year":"2014","journal-title":"J Virol"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0040","doi-asserted-by":"crossref","first-page":"6798","DOI":"10.1016\/j.vaccine.2014.09.070","article-title":"Live attenuated H7N7 influenza vaccine primes for a vigorous antibody response to inactivated H7N7 influenza vaccine","volume":"32","author":"Babu","year":"2014","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0041","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1086\/596558","article-title":"A live attenuated H9N2 influenza vaccine is well tolerated and immunogenic in healthy adults","volume":"199","author":"Karron","year":"2009","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0042","doi-asserted-by":"crossref","first-page":"4953","DOI":"10.1016\/j.vaccine.2009.05.099","article-title":"Evaluation of two live attenuated cold-adapted H5N1 influenza virus vaccines in healthy adults","volume":"27","author":"Karron","year":"2009","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0043","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1093\/infdis\/jiv526","article-title":"Evaluation of the safety and immunogenicity of a candidate pandemic live attenuated influenza vaccine (pLAIV) against influenza A(H7N9)","volume":"213","author":"Sobhanie","year":"2016","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0044","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1016\/j.vaccine.2009.03.082","article-title":"A live attenuated H7N3 influenza virus vaccine is well tolerated and immunogenic in a Phase I trial in healthy adults","volume":"27","author":"Talaat","year":"2009","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0045","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1750-2659.2012.00350.x","article-title":"An open-label phase I trial of a live attenuated H2N2 influenza virus vaccine in healthy adults","volume":"7","author":"Talaat","year":"2013","journal-title":"Influenza Other Respir Viruses"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0046","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1016\/j.vaccine.2011.02.043","article-title":"An open label Phase I trial of a live attenuated H6N1 influenza virus vaccine in healthy adults","volume":"29","author":"Talaat","year":"2011","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0047","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S1473-3099(11)70240-7","article-title":"DNA priming and influenza vaccine immunogenicity: two phase 1 open label randomised clinical trials","volume":"11","author":"Ledgerwood","year":"2011","journal-title":"Lancet Infect Dis"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0048","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/S0140-6736(00)05066-2","article-title":"Safety and antigenicity of non-adjuvanted and MF59-adjuvanted influenza A\/Duck\/Singapore\/97 (H5N3) vaccine: a randomised trial of two potential vaccines against H5N1 influenza","volume":"357","author":"Nicholson","year":"2001","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0049","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1016\/S0264-410X(00)00395-9","article-title":"Safety and immunogenicity of a recombinant hemagglutinin vaccine for H5 influenza in humans","volume":"19","author":"Treanor","year":"2001","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0050","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1086\/526537","article-title":"Evaluation of the safety and immunogenicity of a booster (third) dose of inactivated subvirion H5N1 influenza vaccine in humans","volume":"197","author":"Zangwill","year":"2008","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0051","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1093\/infdis\/jiu123","article-title":"A live attenuated influenza A(H5N1) vaccine induces long-term immunity in the absence of a primary antibody response","volume":"209","author":"Talaat","year":"2014","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0052","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S1473-3099(12)70345-6","article-title":"Safety and immunogenicity of an oral, replicating adenovirus serotype 4 vector vaccine for H5N1 influenza: a randomised, double-blind, placebo-controlled, phase 1 study","volume":"13","author":"Gurwith","year":"2013","journal-title":"Lancet Infect Dis"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0053","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/infdis\/jit178","article-title":"DNA priming prior to inactivated influenza A(H5N1) vaccination expands the antibody epitope repertoire and increases affinity maturation in a boost-interval-dependent manner in adults","volume":"208","author":"Khurana","year":"2013","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0054","article-title":"Intranasal live influenza vaccine priming elicits localized B cell responses in mediastinal lymph nodes","volume":"92:e01970\u201317","author":"Jegaskanda","year":"2018","journal-title":"J Virol"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0055","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1056\/NEJMoa1700153","article-title":"Influenza vaccine effectiveness in the United States during the 2015\u20132016 season","volume":"377","author":"Jackson","year":"2017","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0056","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/S1473-3099(17)30360-2","article-title":"Urgent challenges in implementing live attenuated influenza vaccine","volume":"18","author":"Singanayagam","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0057","doi-asserted-by":"crossref","first-page":"643","DOI":"10.15585\/mmwr.mm6722a5","article-title":"Update: ACIP Recommendations for the use of quadrivalent live attenuated influenza vaccine (LAIV4) - United States, 2018-19 influenza season","volume":"67","author":"Grohskopf","year":"2018","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0058","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1586\/14760584.2014.966695","article-title":"Potential of the test-negative design for measuring influenza vaccine effectiveness: a systematic review","volume":"13","author":"Sullivan","year":"2014","journal-title":"Expert Rev Vaccines"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0059","doi-asserted-by":"crossref","first-page":"4940","DOI":"10.1016\/j.vaccine.2008.07.013","article-title":"Shedding and immunogenicity of live attenuated influenza vaccine virus in subjects 5-49 years of age","volume":"26","author":"Block","year":"2008","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0060","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1086\/589885","article-title":"Prevention of symptomatic seasonal influenza in 2005\u20132006 by inactivated and live attenuated vaccines","volume":"198","author":"Ohmit","year":"2008","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0061","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0264-410X(99)00334-5","article-title":"Evaluation of trivalent, live, cold-adapted (CAIV-T) and inactivated (TIV) influenza vaccines in prevention of virus infection and illness following challenge of adults with wild-type influenza A (H1N1), A (H3N2), and B viruses","volume":"18","author":"Treanor","year":"1999","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0062","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1056\/NEJMoa0907413","article-title":"Response to a monovalent 2009 influenza A (H1N1) vaccine","volume":"361","author":"Greenberg","year":"2009","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0063","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1056\/NEJMoa0908535","article-title":"A novel influenza A (H1N1) vaccine in various age groups","volume":"361","author":"Zhu","year":"2009","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0064","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1126\/science.aah5869","article-title":"Generation of influenza A viruses as live but replication-incompetent virus vaccines","volume":"354","author":"Si","year":"2016","journal-title":"Science"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0065","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1126\/science.aan8806","article-title":"Genome-wide identification of interferon-sensitive mutations enables influenza vaccine design","volume":"359","author":"Du","year":"2018","journal-title":"Science"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0066","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.coviro.2013.05.001","article-title":"Role of T cell immunity in recovery from influenza virus infection","volume":"3","author":"Sun","year":"2013","journal-title":"Curr Opin Virol"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0067","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/326881a0","article-title":"Cytotoxic T lymphocytes recognize a fragment of influenza virus matrix protein in association with HLA-A2","volume":"326","author":"Gotch","year":"1987","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0068","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1084\/jem.160.2.552","article-title":"The influenza A virus nucleoprotein gene controls the induction of both subtype specific and cross-reactive cytotoxic T cells","volume":"160","author":"Townsend","year":"1984","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0069","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1073\/pnas.82.6.1785","article-title":"Influenza A virus nucleoprotein is a major target antigen for cross-reactive anti-influenza A virus cytotoxic T lymphocytes","volume":"82","author":"Yewdell","year":"1985","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0070","doi-asserted-by":"crossref","first-page":"13397","DOI":"10.1128\/JVI.01820-12","article-title":"Pseudotyped influenza A virus as a vaccine for the induction of heterotypic immunity","volume":"86","author":"Powell","year":"2012","journal-title":"J Virol"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0071","doi-asserted-by":"crossref","first-page":"e01487","DOI":"10.1128\/mBio.01487-15","article-title":"Nonreplicating influenza A virus vaccines confer broad protection against lethal challenge","volume":"6","author":"Baz","year":"2015","journal-title":"MBio"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0072","doi-asserted-by":"crossref","first-page":"4068","DOI":"10.4049\/jimmunol.1800142","article-title":"Comparison of heterosubtypic protection in ferrets and pigs induced by a single-cycle influenza vaccine","volume":"200","author":"Holzer","year":"2018","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0073","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.4049\/jimmunol.1502632","article-title":"Aerosol delivery of a candidate universal influenza vaccine reduces viral load in pigs challenged with pandemic H1N1 virus","volume":"196","author":"Morgan","year":"2016","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t2019040805025343900_CIT0074","doi-asserted-by":"crossref","first-page":"e85832","DOI":"10.1172\/jci.insight.85832","article-title":"Vaccine-generated lung tissue-resident memory T cells provide heterosubtypic protection to influenza infection","volume":"1","author":"Zens","year":"2016","journal-title":"JCI Insight"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/219\/Supplement_1\/S81\/28263966\/jiy703.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T04:11:51Z","timestamp":1605931911000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/219\/Supplement_1\/S81\/5304927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,8]]},"references-count":74,"journal-issue":{"issue":"Supplement_1","published-online":{"date-parts":[[2019,4,8]]},"published-print":{"date-parts":[[2019,4,8]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiy703","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,4,15]]},"published":{"date-parts":[[2019,4,8]]}}}