{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:26:22Z","timestamp":1783038382821,"version":"3.54.6"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T00:00:00Z","timestamp":1550448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01KI 07143"],"award-info":[{"award-number":["01KI 07143"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","award":["FP7-INFLUENZA-2010 ESNIP3"],"award-info":[{"award-number":["FP7-INFLUENZA-2010 ESNIP3"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","award":["259949"],"award-info":[{"award-number":["259949"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["He1168\/15-1"],"award-info":[{"award-number":["He1168\/15-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["He1168\/19-1"],"award-info":[{"award-number":["He1168\/19-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"German Federal Ministry of Education and Research","award":["01KI7142"],"award-info":[{"award-number":["01KI7142"]}]},{"name":"German Federal Ministry of Education and Research","award":["01KI1006J"],"award-info":[{"award-number":["01KI1006J"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,19]]},"DOI":"10.1093\/infdis\/jiy719","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T15:13:25Z","timestamp":1548947605000},"page":"1596-1604","source":"Crossref","is-referenced-by-count":16,"title":["Infection Studies in Pigs and Porcine Airway Epithelial Cells Reveal an Evolution of A(H1N1)pdm09 Influenza A Viruses Toward Lower Virulence"],"prefix":"10.1093","volume":"219","author":[{"given":"Yuguang","family":"Fu","sequence":"first","affiliation":[{"name":"Institute of Virology, University of Veterinary Medicine Hannover, Foundation, Germany"},{"name":"State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"D\u00fcrrwald","sequence":"additional","affiliation":[{"name":"Division of Experimental Virology, Department for Medical Microbiology, Jena University Hospital, Friedrich Schiller University, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fandan","family":"Meng","sequence":"additional","affiliation":[{"name":"Institute of Virology, University of Veterinary Medicine Hannover, Foundation, Germany"},{"name":"State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tong","sequence":"additional","affiliation":[{"name":"Institute of Virology, University of Veterinary Medicine Hannover, Foundation, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai-Huei","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Virology, University of Veterinary Medicine Hannover, Foundation, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang","family":"Su","sequence":"additional","affiliation":[{"name":"Institute of Virology, University of Veterinary Medicine Hannover, Foundation, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangping","family":"Yin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwig","family":"Haas","sequence":"additional","affiliation":[{"name":"Institute of Virology, University of Veterinary Medicine Hannover, Foundation, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Schmidtke","sequence":"additional","affiliation":[{"name":"Division of Experimental Virology, Department for Medical Microbiology, Jena University Hospital, Friedrich Schiller University, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Zell","sequence":"additional","affiliation":[{"name":"Division of Experimental Virology, Department for Medical Microbiology, Jena University Hospital, Friedrich Schiller University, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andi","family":"Krumbholz","sequence":"additional","affiliation":[{"name":"Institute of Infection Medicine, Kiel University, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Herrler","sequence":"additional","affiliation":[{"name":"Institute of Virology, University of Veterinary Medicine Hannover, Foundation, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,2,18]]},"reference":[{"key":"2019041904031525100_CIT0001","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nature08157","article-title":"Emergence and pandemic potential of swine-origin H1N1 influenza virus","volume":"459","author":"Neumann","year":"2009","journal-title":"Nature"},{"key":"2019041904031525100_CIT0002","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1126\/science.1176225","article-title":"Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans","volume":"325","author":"Garten","year":"2009","journal-title":"Science"},{"key":"2019041904031525100_CIT0003","volume-title":"WHO global alert and response: pandemic (H1N1) 2009\u2014update 112. Geneva, Switzerland: WHO,","author":"World Health Organization","year":"2010"},{"key":"2019041904031525100_CIT0004","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S1473-3099(12)70121-4","article-title":"Estimated global mortality associated with the first 12 months of 2009 pandemic influenza A H1N1 virus circulation: a modelling study","volume":"12","author":"Dawood","year":"2012","journal-title":"Lancet Infect Dis"},{"key":"2019041904031525100_CIT0005","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1750-2659.2012.00419.x","article-title":"Hospitalizations from pandemic influenza [A(H1N1)pdm09] infections among type 1 and 2 diabetes patients in Spain","volume":"7","author":"Jim\u00e9nez-Garc\u00eda","year":"2013","journal-title":"Influenza Other Respir Viruses"},{"key":"2019041904031525100_CIT0006","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1080\/23744235.2016.1201721","article-title":"Weight and prognosis for influenza A(H1N1)pdm09 infection during the pandemic period between 2009 and 2011: a systematic review of observational studies with meta-analysis","volume":"48","author":"Sun","year":"2016","journal-title":"Infect Dis (Lond)"},{"key":"2019041904031525100_CIT0007","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1097\/AOG.0b013e3181d57947","article-title":"Severity of 2009 pandemic influenza A (H1N1) virus infection in pregnant women","volume":"115","author":"Creanga","year":"2010","journal-title":"Obstet Gynecol"},{"key":"2019041904031525100_CIT0008","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1056\/NEJMoa0903810","article-title":"Emergence of a novel swine-origin influenza A (H1N1) virus in human","volume":"360","author":"Dawood","year":"2009","journal-title":"N Engl J Med"},{"key":"2019041904031525100_CIT0009","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nature14460","article-title":"Global circulation patterns of seasonal influenza viruses vary with antigenic drift","volume":"523","author":"Bedford","year":"2015","journal-title":"Nature"},{"key":"2019041904031525100_CIT0010","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.chom.2010.05.008","article-title":"Cellular networks involved in the influenza virus life cycle","volume":"7","author":"Watanabe","year":"2010","journal-title":"Cell Host Microbe"},{"key":"2019041904031525100_CIT0011","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.coviro.2015.08.008","article-title":"Influenza virus-host interactomes as a basis for antiviral drug development","volume":"14","author":"Watanabe","year":"2015","journal-title":"Curr Opin Virol"},{"key":"2019041904031525100_CIT0012","doi-asserted-by":"crossref","first-page":"e24997","DOI":"10.4161\/tisb.24997","article-title":"Barrier function of airway tract epithelium","volume":"1","author":"Ganesan","year":"2013","journal-title":"Tissue Barriers"},{"key":"2019041904031525100_CIT0013","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1146\/annurev-physiol-021014-071931","article-title":"Cilia dysfunction in lung disease","volume":"77","author":"Tilley","year":"2015","journal-title":"Annu Rev Physiol"},{"key":"2019041904031525100_CIT0014","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1297-9716-45-20","article-title":"Three viruses of the bovine respiratory disease complex apply different strategies to initiate infection","volume":"45","author":"Kirchhoff","year":"2014","journal-title":"Vet Res"},{"key":"2019041904031525100_CIT0015","doi-asserted-by":"crossref","first-page":"6081","DOI":"10.1128\/JVI.03368-12","article-title":"Isolation and characterization of current human coronavirus strains in primary human epithelial cell cultures reveal differences in target cell tropism","volume":"87","author":"Dijkman","year":"2013","journal-title":"J Virol"},{"key":"2019041904031525100_CIT0016","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jviromet.2011.08.025","article-title":"A differentiated porcine bronchial epithelial cell culture model for studying human adenovirus tropism and virulence","volume":"178","author":"Lam","year":"2011","journal-title":"J Virol Methods"},{"key":"2019041904031525100_CIT0017","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1165\/rcmb.2006-0286OC","article-title":"Bioelectric properties of chloride channels in human, pig, ferret, and mouse airway epithelia","volume":"36","author":"Liu","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2019041904031525100_CIT0018","doi-asserted-by":"crossref","first-page":"39668","DOI":"10.1038\/srep39668","article-title":"The differentiated airway epithelium infected by influenza viruses maintains the barrier function despite a dramatic loss of ciliated cells","volume":"6","author":"Wu","year":"2016","journal-title":"Sci Rep"},{"key":"2019041904031525100_CIT0019","doi-asserted-by":"crossref","first-page":"6844","DOI":"10.1128\/JVI.02200-10","article-title":"Viral replication and innate host responses in primary human alveolar epithelial cells and alveolar macrophages infected with influenza H5N1 and H1N1 viruses","volume":"85","author":"Yu","year":"2011","journal-title":"J Virol"},{"key":"2019041904031525100_CIT0020","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1093\/infdis\/jis455","article-title":"Influenza A viruses target type II pneumocytes in the human lung","volume":"206","author":"Weinheimer","year":"2012","journal-title":"J Infect Dis"},{"key":"2019041904031525100_CIT0021","doi-asserted-by":"crossref","first-page":"e61597","DOI":"10.1371\/journal.pone.0061597","article-title":"Efficacy of influenza vaccination and Tamiflu treatment\u2014comparative studies with Eurasian swine influenza viruses in pigs","volume":"8","author":"Duerrwald","year":"2013","journal-title":"PLoS One"},{"key":"2019041904031525100_CIT0022","first-page":"11","article-title":"Swine influenza control by vaccination. Pig progress","volume":"20","author":"D\u00fcrrwald","year":"2001","journal-title":"Spec Resp Dis"},{"key":"2019041904031525100_CIT0023","first-page":"183","article-title":"Well-differentiated human airway epithelial cell cultures","volume":"107","author":"Fulcher","year":"2005","journal-title":"Methods Mol Med"},{"key":"2019041904031525100_CIT0024","doi-asserted-by":"crossref","first-page":"26748","DOI":"10.1038\/srep26748","article-title":"Efficient suilysin-mediated invasion and apoptosis in porcine respiratory epithelial cells after streptococcal infection under air-liquid interface conditions","volume":"6","author":"Meng","year":"2016","journal-title":"Sci Rep"},{"key":"2019041904031525100_CIT0025","doi-asserted-by":"crossref","first-page":"e02125-16","DOI":"10.1128\/JVI.02125-16","article-title":"Mutations during the adaptation of H9N2 avian influenza virus to the respiratory epithelium of pigs enhance sialic acid binding activity and virulence in mice","volume":"91","author":"Yang","year":"2017","journal-title":"J Virol"},{"key":"2019041904031525100_CIT0026","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.chom.2010.05.009","article-title":"Influenza virus evolution, host adaptation, and pandemic formation","volume":"7","author":"Taubenberger","year":"2010","journal-title":"Cell Host Microbe"},{"key":"2019041904031525100_CIT0027","doi-asserted-by":"crossref","first-page":"e115815","DOI":"10.1371\/journal.pone.0115815","article-title":"European surveillance network for influenza in pigs: surveillance programs, diagnostic tools and swine influenza virus subtypes identified in 14 European countries from 2010 to 2013","volume":"9","author":"Simon","year":"2014","journal-title":"PLoS One"},{"key":"2019041904031525100_CIT0028","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/ilar\/ilv002","article-title":"Swine as a model for influenza A virus infection and immunity","volume":"56","author":"Rajao","year":"2015","journal-title":"ILAR J"},{"key":"2019041904031525100_CIT0029","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tim.2011.11.002","article-title":"The pig: a model for human infectious diseases","volume":"20","author":"Meurens","year":"2012","journal-title":"Trends Microbiol"},{"key":"2019041904031525100_CIT0030","doi-asserted-by":"crossref","first-page":"e1003831","DOI":"10.1371\/journal.ppat.1003831","article-title":"A single amino acid in the stalk region of the H1N1pdm influenza virus HA protein affects viral fusion, stability and infectivity","volume":"10","author":"Cotter","year":"2014","journal-title":"PLoS Pathog"},{"key":"2019041904031525100_CIT0031","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1046\/j.1365-2672.2001.01492.x","article-title":"A history of influenza","volume":"91","author":"Potter","year":"2001","journal-title":"J Appl Microbiol"},{"key":"2019041904031525100_CIT0032","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.virol.2015.03.009","article-title":"Transmission of influenza A viruses","volume":"479\u2013480","author":"Neumann","year":"2015","journal-title":"Virology"},{"key":"2019041904031525100_CIT0033","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.vetmic.2013.09.024","article-title":"Reassortants of the pandemic (H1N1) 2009 virus and establishment of a novel porcine H1N2 influenza virus, lineage in Germany","volume":"167","author":"Lange","year":"2013","journal-title":"Vet Microbiol"},{"key":"2019041904031525100_CIT0034","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.virol.2011.10.018","article-title":"Virulence differences of closely related pandemic 2009 H1N1 isolates correlate with increased inflammatory responses in ferrets","volume":"422","author":"Meunier","year":"2012","journal-title":"Virology"},{"key":"2019041904031525100_CIT0035","doi-asserted-by":"crossref","first-page":"13269","DOI":"10.1128\/JVI.01636-14","article-title":"Accumulation of human-adapting mutations during circulation of A(H1N1)pdm09 influenza virus in humans in the United Kingdom","volume":"88","author":"Elderfield","year":"2014","journal-title":"J Virol"},{"key":"2019041904031525100_CIT0036","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1297-9716-44-110","article-title":"Replication characteristics of swine influenza viruses in precision-cut lung slices reflect the virulence properties of the viruses","volume":"44","author":"Meng","year":"2013","journal-title":"Vet Res"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/219\/10\/1596\/28486442\/jiy719.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T04:03:32Z","timestamp":1555646612000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/219\/10\/1596\/5334094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,18]]},"references-count":36,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,2,18]]},"published-print":{"date-parts":[[2019,4,19]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiy719","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,5,15]]},"published":{"date-parts":[[2019,2,18]]}}}