{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:23:25Z","timestamp":1787009005147,"version":"build-2736575974"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T00:00:00Z","timestamp":1548892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100008065","name":"Georgia Research Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,8]]},"DOI":"10.1093\/infdis\/jiz004","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:24:15Z","timestamp":1547511855000},"page":"S57-S61","source":"Crossref","is-referenced-by-count":7,"title":["Universal Influenza Vaccine Approaches Using Full-Length or Head-Only Hemagglutinin Proteins"],"prefix":"10.1093","volume":"219","author":[{"given":"Ted M","family":"Ross","sequence":"first","affiliation":[{"name":"Center for Vaccines and Immunology, University of Georgia, Athens"},{"name":"Department of Infectious Diseases, University of Georgia, Athens"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,4,8]]},"reference":[{"key":"key\n\t\t\t\t2019040805025625400_CIT0001","doi-asserted-by":"crossref","first-page":"D65","DOI":"10.1016\/j.vaccine.2009.08.038","article-title":"Influenza vaccines","volume":"27","author":"Ellebedy","year":"2009","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0002","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/infdis\/jiy103","article-title":"A universal influenza vaccine: the strategic plan for the national institute of allergy and infectious diseases","volume":"218","author":"Erbelding","year":"2018","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0003","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/rmv.657","article-title":"Novel insights into proteolytic cleavage of influenza virus hemagglutinin","volume":"20","author":"Bertram","year":"2010","journal-title":"Rev Med Virol"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0004","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev.bi.56.070187.002053","article-title":"The structure and function of the hemagglutinin membrane glycoprotein of influenza virus","volume":"56","author":"Wiley","year":"1987","journal-title":"Annu Rev Biochem"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0005","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1073\/pnas.1200039109","article-title":"Hemagglutinin stalk antibodies elicited by the 2009 pandemic influenza virus as a mechanism for the extinction of seasonal H1N1 viruses","volume":"109","author":"Pica","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0006","doi-asserted-by":"crossref","first-page":"13260","DOI":"10.1128\/JVI.02133-14","article-title":"Induction of broadly reactive anti-hemagglutinin stalk antibodies by an H5N1 vaccine in humans","volume":"88","author":"Nachbagauer","year":"2014","journal-title":"J Virol"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0007","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1128\/JVI.03183-13","article-title":"H3 stalk-based chimeric hemagglutinin influenza virus constructs protect mice from H7N9 challenge","volume":"88","author":"Krammer","year":"2014","journal-title":"J Virol"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0008","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1128\/JVI.03004-13","article-title":"Assessment of influenza virus hemagglutinin stalk-based immunity in ferrets","volume":"88","author":"Krammer","year":"2014","journal-title":"J Virol"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0009","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/nm.3927","article-title":"Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection","volume":"21","author":"Yassine","year":"2015","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0010","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nbt.3907","article-title":"Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site","volume":"35","author":"Strauch","year":"2017","journal-title":"Nat Biotechnol"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0011","doi-asserted-by":"crossref","first-page":"e71534","DOI":"10.1371\/journal.pone.0071534","article-title":"Heterosubtypic antiviral activity of hemagglutinin-specific antibodies induced by intranasal immunization with inactivated influenza viruses in mice","volume":"8","author":"Muramatsu","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0012","first-page":"171","article-title":"The role of the antibody response in influenza virus infection","volume":"260","author":"Gerhard","year":"2001","journal-title":"Curr Top Microbiol Immunol"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0013","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1126\/science.1225416","article-title":"Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses","volume":"337","author":"Burton","year":"2012","journal-title":"Science"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0014","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/oxfordjournals.bmb.a071545","article-title":"Determinants of immunity to influenza infection in man","volume":"35","author":"Potter","year":"1979","journal-title":"Br Med Bull"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0015","first-page":"767","article-title":"The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B viruses","volume":"70","author":"Hobson","year":"1972","journal-title":"J Hyg (Lond)"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0016","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-2288-10-18","article-title":"Relationship between haemagglutination-inhibiting antibody titres and clinical protection against influenza: development and application of a Bayesian random-effects model","volume":"10","author":"Coudeville","year":"2010","journal-title":"BMC Med Res Methodol"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0017","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1128\/CVI.00613-15","article-title":"Standardization of hemagglutination inhibition assay for influenza serology allows for high reproducibility between laboratories","volume":"23","author":"Zacour","year":"2016","journal-title":"Clin Vaccine Immunol"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0018","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1128\/CVI.00131-10","article-title":"Correlates of protection induced by vaccination","volume":"17","author":"Plotkin","year":"2010","journal-title":"Clin Vaccine Immunol"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0019","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1126\/science.288.5468.1051","article-title":"Influenza B virus in seals","volume":"288","author":"Osterhaus","year":"2000","journal-title":"Science"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0020","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1093\/infdis\/jiw644","article-title":"Moving toward improved influenza vaccines","volume":"215","author":"Monto","year":"2017","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0021","doi-asserted-by":"crossref","first-page":"28403","DOI":"10.1074\/jbc.R110.129809","article-title":"Influenza hemagglutinin and neuraminidase membrane glycoproteins","volume":"285","author":"Gamblin","year":"2010","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0022","first-page":"820","article-title":"Influenza A virus recycling revisited","volume":"77","author":"Dowdle","year":"1999","journal-title":"Bull World Health Organ"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0023","first-page":"475","article-title":"Immunological interrelationships of Hong Kong, Asian and equi-2 influenza viruses in man","volume":"41","author":"Marine","year":"1969","journal-title":"Bull World Health Organ"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0024","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/S0140-6736(58)91738-0","article-title":"Pre-epidemic antibody against 1957 strain of Asiatic influenza in serum of older people living in the Netherlands","volume":"1","author":"Mulder","year":"1958","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0025","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1084\/jem.63.5.669","article-title":"The incidence of neutralizing antibodies for swine influenza virus in the sera of human beings of different ages","volume":"63","author":"Shope","year":"1936","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0026","first-page":"566","article-title":"Influenza: observations on the recovery of virus from man and on the antibody content of human sera","volume":"16","author":"Andrews","year":"1935","journal-title":"Br J Exp Path"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0027","first-page":"453","article-title":"Interpretations of influenza antibody patterns of man","volume":"41","author":"Davenport","year":"1969","journal-title":"Bull World Health Organ"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0028","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/0042-6822(78)90207-6","article-title":"Antigenic similarity of influenza A (H1N1) viruses from epidemics in 1977\u20131978 to \u201cScandinavian\u201d strains isolated in epidemics of 1950\u20131951","volume":"89","author":"Kendal","year":"1978","journal-title":"Virology"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0029","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00946-18","article-title":"Elicitation of protective antibodies against 20 years of future H3N2 co-ciruculating influenza virus variants in ferrets preimmune to historical H3N2 influenza viruses","author":"Allen","year":"2018","journal-title":"J Virol"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0030","doi-asserted-by":"crossref","first-page":"e0204284","DOI":"10.1371\/journal.pone.0204284","article-title":"Split inactivated COBRA vaccine elicits protective antibodies against H1N1 and H3N2 influenza viruses","volume":"13","author":"Allen","year":"2018","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0031","doi-asserted-by":"crossref","first-page":"e01283-17","DOI":"10.1128\/JVI.01283-17","article-title":"Elicitation of protective antibodies against a broad panel of H1N1 viruses in ferrets preimmune to historical H1N1 influenza viruses","volume":"91","author":"Carter","year":"2017","journal-title":"J Virol"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0032","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1128\/JVI.03152-15","article-title":"Design and characterization of a computationally optimized broadly reactive hemagglutinin vaccine for H1N1 influenza viruses","volume":"90","author":"Carter","year":"2016","journal-title":"J Virol"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0033","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1093\/infdis\/jis232","article-title":"A computationally optimized hemagglutinin virus-like particle vaccine elicits broadly reactive antibodies that protect nonhuman primates from H5N1 infection","volume":"205","author":"Giles","year":"2012","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0034","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1016\/j.vaccine.2011.01.100","article-title":"A computationally optimized broadly reactive antigen (COBRA) based H5N1 VLP vaccine elicits broadly reactive antibodies in mice and ferrets","volume":"29","author":"Giles","year":"2011","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t2019040805025625400_CIT0035","doi-asserted-by":"crossref","first-page":"e01581-17","DOI":"10.1128\/JVI.01581-17","article-title":"Computationally optimized broadly reactive hemagglutinin elicits hemagglutination inhibition antibodies against a panel of H3N2 influenza virus cocirculating variants","volume":"91","author":"Wong","year":"2017","journal-title":"J Virol"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/219\/Supplement_1\/S57\/28263968\/jiz004.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T06:02:19Z","timestamp":1573711339000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/219\/Supplement_1\/S57\/5304925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,8]]},"references-count":35,"journal-issue":{"issue":"Supplement_1","published-online":{"date-parts":[[2019,4,8]]},"published-print":{"date-parts":[[2019,4,8]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiz004","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,4,15]]},"published":{"date-parts":[[2019,4,8]]}}}