{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:50:10Z","timestamp":1780487410060,"version":"3.54.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T00:00:00Z","timestamp":1547078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AI-087881"],"award-info":[{"award-number":["U01 AI-087881"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI-134940"],"award-info":[{"award-number":["R01 AI-134940"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI-137091"],"award-info":[{"award-number":["R01 AI-137091"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI-108588"],"award-info":[{"award-number":["R01 AI-108588"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UG3 OD-023253"],"award-info":[{"award-number":["UG3 OD-023253"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,24]]},"DOI":"10.1093\/infdis\/jiz021","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T04:34:03Z","timestamp":1547008443000},"page":"2005-2014","source":"Crossref","is-referenced-by-count":32,"title":["Serum Metabolome Is Associated With the Nasopharyngeal Microbiota and Disease Severity Among Infants With Bronchiolitis"],"prefix":"10.1093","volume":"219","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6033-338X","authenticated-orcid":false,"given":"Christopher J","family":"Stewart","sequence":"first","affiliation":[{"name":"Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas"},{"name":"Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M","family":"Mansbach","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston Children\u2019s Hospital, Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadim J","family":"Ajami","sequence":"additional","affiliation":[{"name":"Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph F","family":"Petrosino","sequence":"additional","affiliation":[{"name":"Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaozhong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, United States"},{"name":"Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, United States"},{"name":"Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Carlos A","family":"Camargo","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School"},{"name":"Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, United States"},{"name":"Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,1,10]]},"reference":[{"key":"2019052411110309800_CIT0001","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0140-6736(10)60206-1","article-title":"Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis","volume":"375","author":"Nair","year":"2010","journal-title":"Lancet"},{"key":"2019052411110309800_CIT0002","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1542\/peds.2012-3877","article-title":"Trends in bronchiolitis hospitalizations in the United States, 2000-2009","volume":"132","author":"Hasegawa","year":"2013","journal-title":"Pediatrics"},{"key":"2019052411110309800_CIT0003","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1080\/17476348.2016.1190647","article-title":"Advancing our understanding of infant bronchiolitis through phenotyping and endotyping: clinical and molecular approaches","volume":"10","author":"Hasegawa","year":"2016","journal-title":"Expert Rev Respir Med"},{"key":"2019052411110309800_CIT0004","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1164\/rccm.201701-0071OC","article-title":"Associations of nasopharyngeal metabolome and microbiome with severity among infants with bronchiolitis. A multiomic analysis","volume":"196","author":"Stewart","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"2019052411110309800_CIT0005","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1093\/infdis\/jiw456","article-title":"Differences in the nasopharyngeal microbiome during acute respiratory tract infection with human rhinovirus and respiratory syncytial virus in infancy","volume":"214","author":"Rosas-Salazar","year":"2016","journal-title":"J Infect Dis"},{"key":"2019052411110309800_CIT0006","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.chom.2015.03.008","article-title":"The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development","volume":"17","author":"Teo","year":"2015","journal-title":"Cell Host Microbe"},{"key":"2019052411110309800_CIT0007","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1016\/j.jaci.2016.01.036","article-title":"Respiratory syncytial virus and rhinovirus severe bronchiolitis are associated with distinct nasopharyngeal microbiota","volume":"137","author":"Mansbach","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"2019052411110309800_CIT0008","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1164\/rccm.201602-0220OC","article-title":"Nasopharyngeal microbiota, host transcriptome, and disease severity in children with respiratory syncytial virus infection","volume":"194","author":"de Steenhuijsen Piters","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"2019052411110309800_CIT0009","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.chest.2016.10.008","article-title":"Asthma metabolomics and the potential for integrative omics in research and the clinic","volume":"151","author":"Kelly","year":"2017","journal-title":"Chest"},{"key":"2019052411110309800_CIT0010","volume-title":"Emergency Medicine Network","author":"EMNet"},{"key":"2019052411110309800_CIT0011","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1183\/13993003.00152-2016","article-title":"Association of nasopharyngeal microbiota profiles with bronchiolitis severity in infants hospitalised for bronchiolitis","volume":"48","author":"Hasegawa","year":"2016","journal-title":"Eur Respir J"},{"key":"2019052411110309800_CIT0012","doi-asserted-by":"crossref","first-page":"e1474","DOI":"10.1542\/peds.2014-2742","article-title":"Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis","volume":"134","author":"Ralston","year":"2014","journal-title":"Pediatrics"},{"key":"2019052411110309800_CIT0013","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1093\/infdis\/jiu658","article-title":"Respiratory syncytial virus genomic load and disease severity among children hospitalized with bronchiolitis: multicenter cohort studies in the United States and Finland","volume":"211","author":"Hasegawa","year":"2015","journal-title":"J Infect Dis"},{"key":"2019052411110309800_CIT0014","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jaci.2015.02.021","article-title":"Rhinovirus-induced bronchiolitis: lack of association between virus genomic load and short-term outcomes","volume":"136","author":"Jartti","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"2019052411110309800_CIT0015","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1021\/ac051495j","article-title":"Large-scale human metabolomics studies: a strategy for data (pre-) processing and validation","volume":"78","author":"Bijlsma","year":"2006","journal-title":"Anal Chem"},{"key":"2019052411110309800_CIT0016","doi-asserted-by":"crossref","first-page":"W251","DOI":"10.1093\/nar\/gkv380","article-title":"MetaboAnalyst 3.0\u2013making metabolomics more meaningful","volume":"43","author":"Xia","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2019052411110309800_CIT0017","volume-title":"R: a language and environment for statistical computing","author":"Team RC","year":"2014"},{"key":"2019052411110309800_CIT0018","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Ser B"},{"key":"2019052411110309800_CIT0019","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1093\/bioinformatics\/btp515","article-title":"integrOmics: an R package to unravel relationships between two omics datasets","volume":"25","author":"L\u00ea Cao","year":"2009","journal-title":"Bioinformatics"},{"key":"2019052411110309800_CIT0020","doi-asserted-by":"crossref","first-page":"e0127098","DOI":"10.1371\/journal.pone.0127098","article-title":"Streptococcus pneumoniae enhances human respiratory syncytial virus infection in vitro and in vivo","volume":"10","author":"Nguyen","year":"2015","journal-title":"PLoS One"},{"key":"2019052411110309800_CIT0021","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1093\/infdis\/jix680","article-title":"Respiratory syncytial virus and rhinovirus bronchiolitis are associated with distinct metabolic pathways","volume":"217","author":"Stewart","year":"2018","journal-title":"J Infect Dis"},{"key":"2019052411110309800_CIT0022","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1111\/all.13160","article-title":"The relationship between nasopharyngeal CCL5 and microbiota on disease severity among infants with bronchiolitis","volume":"72","author":"Hasegawa","year":"2017","journal-title":"Allergy"},{"key":"2019052411110309800_CIT0023","doi-asserted-by":"crossref","first-page":"e20160218","DOI":"10.1542\/peds.2016-0218","article-title":"The fecal microbiota profile and bronchiolitis in infants","volume":"138","author":"Hasegawa","year":"2016","journal-title":"Pediatrics"},{"key":"2019052411110309800_CIT0024","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1186\/s13104-017-2659-9","article-title":"Sphingolipid metabolism potential in fecal microbiome and bronchiolitis in infants: a case-control study","volume":"10","author":"Hasegawa","year":"2017","journal-title":"BMC Res Notes"},{"key":"2019052411110309800_CIT0025","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.3389\/fmicb.2016.01144","article-title":"Gut microbiota profiling: metabolomics based approach to unravel compounds affecting human health","volume":"7","author":"Vernocchi","year":"2016","journal-title":"Front Microbiol"},{"key":"2019052411110309800_CIT0026","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1073\/pnas.0812874106","article-title":"Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites","volume":"106","author":"Wikoff","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2019052411110309800_CIT0027","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature11234","article-title":"Structure, function and diversity of the healthy human microbiome","volume":"486","author":"Human Microbiome Project Consortium","year":"2012","journal-title":"Nature"},{"key":"2019052411110309800_CIT0028","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3389\/fmicb.2015.01085","article-title":"Regulation of lung immunity and host defense by the intestinal microbiota","volume":"6","author":"Samuelson","year":"2015","journal-title":"Front Microbiol"},{"key":"2019052411110309800_CIT0029","doi-asserted-by":"crossref","first-page":"e111228","DOI":"10.1371\/journal.pone.0111228","article-title":"Changes in the bacterial microbiota in gut, blood, and lungs following acute LPS instillation into mice lungs","volume":"9","author":"Sze","year":"2014","journal-title":"PLoS One"},{"key":"2019052411110309800_CIT0030","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nm.3444","article-title":"Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis","volume":"20","author":"Trompette","year":"2014","journal-title":"Nat Med"},{"key":"2019052411110309800_CIT0031","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1165\/rcmb.2016-0052PS","article-title":"Obesity and asthma: microbiome-metabolome interactions","volume":"54","author":"Shore","year":"2016","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2019052411110309800_CIT0032","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.bbadis.2012.05.008","article-title":"Functions of plasmalogen lipids in health and disease","volume":"1822","author":"Braverman","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"2019052411110309800_CIT0033","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1177\/107385840100700308","article-title":"Plasmalogens: workhorse lipids of membranes in normal and injured neurons and glia","volume":"7","author":"Farooqui","year":"2001","journal-title":"Neuroscientist"},{"key":"2019052411110309800_CIT0034","doi-asserted-by":"crossref","first-page":"H671","DOI":"10.1152\/ajpheart.00524.2001","article-title":"Increasing plasmalogen levels protects human endothelial cells during hypoxia","volume":"283","author":"Zoeller","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2019052411110309800_CIT0035","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1097\/00003246-200005000-00052","article-title":"Preterm infants with high polyunsaturated fatty acid and plasmalogen content in tracheal aspirates develop bronchopulmonary dysplasia less often","volume":"28","author":"R\u00fcdiger","year":"2000","journal-title":"Crit Care Med"},{"key":"2019052411110309800_CIT0036","doi-asserted-by":"crossref","first-page":"L379","DOI":"10.1152\/ajplung.00176.2004","article-title":"Naturally derived commercial surfactants differ in composition of surfactant lipids and in surface viscosity","volume":"288","author":"R\u00fcdiger","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2019052411110309800_CIT0037","doi-asserted-by":"crossref","first-page":"e3863","DOI":"10.1371\/journal.pone.0003863","article-title":"Metabolic profiling reveals distinct variations linked to nicotine consumption in humans\u2013first results from the KORA study","volume":"3","author":"Wang-Sattler","year":"2008","journal-title":"PLoS One"},{"key":"2019052411110309800_CIT0038","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/crj.12425","article-title":"Oxidative stress and inflamatory plasma biomarkers in respiratory syncytial virus bronchiolitis","volume":"11","author":"Moreno-Sol\u00eds","year":"2017","journal-title":"Clin Respir J"},{"key":"2019052411110309800_CIT0039","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.mam.2008.07.001","article-title":"Environmental toxicity, redox signaling and lung inflammation: the role of glutathione","volume":"30","author":"Biswas","year":"2009","journal-title":"Mol Aspects Med"},{"key":"2019052411110309800_CIT0040","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1093\/cid\/cix483","article-title":"Serum LL-37 levels associated with severity of bronchiolitis and viral etiology","volume":"65","author":"Mansbach","year":"2017","journal-title":"Clin Infect Dis"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/219\/12\/2005\/28701088\/jiz021.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T22:09:55Z","timestamp":1720908595000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/219\/12\/2005\/5285940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,10]]},"references-count":40,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,1,10]]},"published-print":{"date-parts":[[2019,5,24]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiz021","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,6,15]]},"published":{"date-parts":[[2019,1,10]]}}}