{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:47:45Z","timestamp":1784692065827,"version":"3.55.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T00:00:00Z","timestamp":1550707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020 Research","award":["666100"],"award-info":[{"award-number":["666100"]}]},{"name":"European Union\u2019s Horizon 2020 Research","award":["666092"],"award-info":[{"award-number":["666092"]}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["GU883\/5-1"],"award-info":[{"award-number":["GU883\/5-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In 2015, the laboratory at the Ebola treatment center in Coyah, Guinea, confirmed Ebola virus disease (EVD) in 286 patients. The cycle threshold (Ct) of an Ebola virus\u2013specific reverse transcription\u2013polymerase chain reaction assay and 13 blood chemistry parameters were measured on admission and during hospitalization. Favipiravir treatment was offered to patients with EVD on a compassionate-use basis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>To reduce biases in the raw field data, we carefully selected 163 of 286 patients with EVD for a retrospective study to assess associations between potential risk factors, alterations in blood chemistry findings, favipiravir treatment, and outcome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The case-fatality rate in favipiravir-treated patients was lower than in untreated patients (42.5% [31 of 73] vs 57.8% [52 of 90]; P = .053 by univariate analysis). In multivariate regression analysis, a higher Ct and a younger age were associated with survival (P &lt; .001), while favipiravir treatment showed no statistically significant effect (P = .11). However, Kaplan-Meier analysis indicated a longer survival time in the favipiravir-treated group (P = .015). The study also showed characteristic changes in blood chemistry findings in patients who died, compared with survivors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Consistent with the JIKI trial, this retrospective study revealed a trend toward improved survival in favipiravir- treated patients; however, the effect of treatment was not statistically significant, except for its influence on survival time.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiz078","type":"journal-article","created":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T23:19:03Z","timestamp":1550445543000},"page":"195-202","source":"Crossref","is-referenced-by-count":42,"title":["Laboratory Findings, Compassionate Use of Favipiravir, and Outcome in Patients With Ebola Virus Disease, Guinea, 2015\u2014A Retrospective Observational Study"],"prefix":"10.1093","volume":"220","author":[{"given":"Romy","family":"Kerber","sequence":"first","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine, Hamburg"},{"name":"European Mobile Laboratory Consortium, Hamburg"},{"name":"German Center for Infection Research, Braunschweig"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine, Hamburg"},{"name":"German Center for Infection Research, Braunschweig"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Duraffour","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine, Hamburg"},{"name":"European Mobile Laboratory Consortium, Hamburg"},{"name":"German Center for Infection Research, Braunschweig"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daouda","family":"Sissoko","sequence":"additional","affiliation":[{"name":"INSERM U1219, Bordeaux University, Bordeaux, France"},{"name":"Bordeaux University Hospital, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Rudolf","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine, Hamburg"},{"name":"European Mobile Laboratory Consortium, Hamburg"},{"name":"German Center for Infection Research, Braunschweig"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Jaeger","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine, Hamburg"},{"name":"German Center for Infection Research, Braunschweig"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sekou Ditinn","family":"Cisse","sequence":"additional","affiliation":[{"name":"Ministry of Health Guinea, Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alseny-Modet","family":"Camara","sequence":"additional","affiliation":[{"name":"Ministry of Health Guinea, Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo","family":"Miranda","sequence":"additional","affiliation":[{"name":"Hospital Militar Central Dr. Carlos J. 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