{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:38:45Z","timestamp":1790872725735,"version":"4.1.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T00:00:00Z","timestamp":1556236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Biomarker-Driven Immunosuppression Minimization"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rabbit antithymocyte globulin (rATG) induction is associated with profound immunosuppression, leading to a higher risk of cytomegalovirus (CMV) infection compared with anti\u2013interleukin 2 receptor antibody (anti\u2013IL-2RA). However, this risk, depending on the baseline CMV serological recipient\/donor status, is still controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The CMV DNAemia-free survival between rATG- and anti\u2013IL-2RA\u2013treated patients was analyzed in donor-positive\/recipient-negative (D+R\u2212) and recipient-positive (R+) patients in 1 discovery cohort of 559 kidney transplant recipients (KTRs) and 2 independent cohorts (351 and 135 kidney KTRs). The CMV-specific cell-mediated immunity (CMI) at baseline and at different time points after transplantation was assessed using an interferon \u03b3 enzyme-linked immunosorbent spot assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>rATG increased the risk of CMV DNAemia in R+ but not in D+R\u2212 KTRs. In R+ CMI-positive (CMI+) patients, the CMV DNAemia rate was higher in rATG-treated than in anti\u2013IL-2RA\u2013treated patients; no difference was observed among R+ CMI-negative (CMI\u2212) patients. Longitudinal follow-up demonstrated a deeper depletion of preformed CMV CMI in R+ rATG-treated patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>D+R\u2212 KTRs have the highest risk of CMV DNAemia, but rATG adds no further risk. Among R+ KTRs, we described 3 groups, the least prone being R+CMI+ KTRs without rATG, then R+CMI+ KTRs with rATG, and finally R+CMI\u2212 KTRs. CMV serostatus, baseline CMV-specific CMI, and induction therapy may lead to personalized preventive therapy in further studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiz194","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T15:11:05Z","timestamp":1556118665000},"page":"761-771","source":"Crossref","is-referenced-by-count":23,"title":["Different impact of rATG induction on CMV infection risk in D+R\u2013 and R+ KTRs"],"prefix":"10.1093","volume":"220","author":[{"given":"Hannah","family":"Kaminski","sequence":"first","affiliation":[{"name":"Department of Nephrology, Transplantation, Dialysis and Apheresis, Pellegrin University Hospital, Bordeaux, France"},{"name":"CNRS-UMR 5164 ImmunoConcEpT, Bordeaux University, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Jarque","sequence":"additional","affiliation":[{"name":"Experimental Nephrology Laboratory, IDIBELL, Barcelona, 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