{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:28:14Z","timestamp":1790188094548,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,5,4]],"date-time":"2019-05-04T00:00:00Z","timestamp":1556928000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Themis Bioscience","award":["AI120942"],"award-info":[{"award-number":["AI120942"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chikungunya virus (CHIKV) infection can result in chikungunya fever (CHIKF), a self-limited acute febrile illness that can progress to chronic arthralgic sequelae in a large percentage of patients. A new measles virus-vectored vaccine was developed to prevent CHIKF, and we tested it for immunogenicity and efficacy in a nonhuman primate model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nine cynomolgus macaques were immunized and boosted with the measles virus-vectored chikungunya vaccine or sham-vaccinated. Sera were taken at multiple times during the vaccination phase to assess antibody responses against CHIKV. Macaques were challenged with a dose of CHIKV previously shown to cause fever and viremia, and core body temperature, viremia, and blood cell and chemistry panels were monitored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The vaccine was well tolerated in all macaques, and all seroconverted (high neutralizing antibody [PRNT80 titers, 40\u2013640] and enzyme-linked immunosorbent assay titers) after the boost. Furthermore, the vaccinated primates were protected against viremia, fever, elevated white blood cell counts, and CHIKF-associated cytokine changes after challenge with the virulent La Reuni\u00f3n CHIKV strain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results further document the immunogenicity and efficacy of a measles-vectored chikungunya vaccine that shows promise in Phase I\u2013II clinical trials. These findings are critical to human health because no vaccine to combat CHIKF is yet licensed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiz202","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T15:31:01Z","timestamp":1556292661000},"page":"735-742","source":"Crossref","is-referenced-by-count":59,"title":["Immunogenicity and Efficacy of a Measles Virus-Vectored Chikungunya Vaccine in Nonhuman Primates"],"prefix":"10.1093","volume":"220","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2450-2374","authenticated-orcid":false,"given":"Shannan L","family":"Rossi","sequence":"first","affiliation":[{"name":"Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston"},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason E","family":"Comer","sequence":"additional","affiliation":[{"name":"Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston"},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eryu","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston"},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha R","family":"Azar","sequence":"additional","affiliation":[{"name":"Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston"},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston"},{"name":"Institute for Translational Science, University of Texas Medical Branch, Galveston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston"},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A","family":"Plante","sequence":"additional","affiliation":[{"name":"Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston"},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston"},{"name":"World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Ramsauer","sequence":"additional","affiliation":[{"name":"Themis Bioscience GmbH, Vienna, 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