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A total of 207 datasets generated in this and previous studies using target enrichment and high-throughput sequencing were analyzed, in the process enabling the determination of genome sequences for 91 strains. Key findings were that (i) it is important to monitor the quality of sequencing libraries in investigating variation; (ii) many recombinant strains have been transmitted during HCMV evolution, and some have apparently survived for thousands of years without further recombination; (iii) mutants with nonfunctional genes (pseudogenes) have been circulating and recombining for long periods and can cause congenital infection and resulting clinical sequelae; and (iv) intrahost variation in single-strain infections is much less than that in multiple-strain infections. Future population-based studies are likely to continue illuminating the evolution, epidemiology, and pathogenesis of HCMV.<\/jats:p>","DOI":"10.1093\/infdis\/jiz208","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T15:11:05Z","timestamp":1556118665000},"page":"781-791","source":"Crossref","is-referenced-by-count":103,"title":["Human Cytomegalovirus Genomes Sequenced Directly From Clinical Material: Variation, Multiple-Strain Infection, Recombination, and Gene Loss"],"prefix":"10.1093","volume":"220","author":[{"given":"Nicol\u00e1s M","family":"Su\u00e1rez","sequence":"first","affiliation":[{"name":"Medical Research Council\u2013University of Glasgow Centre for Virus Research, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin S","family":"Wilkie","sequence":"additional","affiliation":[{"name":"Medical Research Council\u2013University of Glasgow Centre for Virus Research, United 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