{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:24:22Z","timestamp":1777515862451,"version":"3.51.4"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T00:00:00Z","timestamp":1557964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Israel Institute for Biological Research","award":["5112\u201352"],"award-info":[{"award-number":["5112\u201352"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pneumonic plague, caused by Yersinia pestis, is a rapidly progressing contagious disease. In the plague mouse model, a single immunization with the EV76 live attenuated Y. pestis strain rapidly induced the expression of hemopexin and haptoglobin in the lung and serum, both of which are important in iron sequestration. Immunization against a concomitant lethal Y. pestis respiratory challenge was correlated with temporary inhibition of disease progression. Combining EV76-immunization and second-line antibiotic treatment, which are individually insufficient, led to a synergistic protective effect that represents a proof of concept for efficient combinational therapy in cases of infection with antibiotic-resistant strains.<\/jats:p>","DOI":"10.1093\/infdis\/jiz260","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T19:12:38Z","timestamp":1557947558000},"page":"1147-1151","source":"Crossref","is-referenced-by-count":13,"title":["Postexposure Administration of a Yersinia pestis Live Vaccine for Potentiation of Second-Line Antibiotic Treatment Against Pneumonic Plague"],"prefix":"10.1093","volume":"220","author":[{"given":"Ayelet","family":"Zauberman","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Gur","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinon","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Aftalion","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaron","family":"Vagima","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avital","family":"Tidhar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodor","family":"Chitlaru","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuelle","family":"Mamroud","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,5,16]]},"reference":[{"key":"2019091012220106400_CIT0001","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1128\/AAC.00306-06","article-title":"Resistance of Yersinia pestis to antimicrobial agents","volume":"50","author":"Galimand","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"2019091012220106400_CIT0002","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ijantimicag.2017.09.015","article-title":"Plasmid-mediated doxycycline resistance in a Yersinia pestis strain isolated from a rat","volume":"51","author":"Cabanel","year":"2018","journal-title":"Int J Antimicrob Agents"},{"key":"2019091012220106400_CIT0003","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1128\/AAC.04548-14","article-title":"In vitro antibiotic susceptibilities of Yersinia pestis determined by broth microdilution following CLSI methods","volume":"59","author":"Heine","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"2019091012220106400_CIT0004","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1128\/AAC.44.7.1995-1996.2000","article-title":"Susceptibilities of Yersinia pestis strains to 12 antimicrobial agents","volume":"44","author":"Wong","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"key":"2019091012220106400_CIT0005","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3389\/fcimb.2017.00277","article-title":"Host iron nutritional immunity induced by a live Yersinia pestis vaccine strain is associated with immediate protection against plague","volume":"7","author":"Zauberman","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"key":"2019091012220106400_CIT0006","doi-asserted-by":"crossref","first-page":"741","DOI":"10.3389\/fmicb.2018.00741","article-title":"Inhalational gentamicin treatment is effective against pneumonic plague in a mouse model","volume":"9","author":"Gur","year":"2018","journal-title":"Front Microbiol"},{"key":"2019091012220106400_CIT0007","doi-asserted-by":"crossref","first-page":"e1004893","DOI":"10.1371\/journal.ppat.1004893","article-title":"Circumventing Y. pestis virulence by early recruitment of neutrophils to the lungs during pneumonic plague","volume":"11","author":"Vagima","year":"2015","journal-title":"PLoS Pathog"},{"key":"2019091012220106400_CIT0008","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.chom.2013.04.010","article-title":"Iron in infection and immunity","volume":"13","author":"Cassat","year":"2013","journal-title":"Cell Host Microbe"},{"key":"2019091012220106400_CIT0009","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1128\/IAI.00602-13","article-title":"Sequestration and scavenging of iron in infection","volume":"81","author":"Parrow","year":"2013","journal-title":"Infect Immun"},{"key":"2019091012220106400_CIT0010","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1128\/AAC.42.3.675","article-title":"Antibiotic treatment of experimental pneumonic plague in mice","volume":"42","author":"Byrne","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"2019091012220106400_CIT0011","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3389\/fphys.2014.00415","article-title":"Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development","volume":"5","author":"Schaer","year":"2014","journal-title":"Front Physiol"},{"key":"2019091012220106400_CIT0012","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1126\/science.7036344","article-title":"Haptoglobin: a natural bacteriostat","volume":"215","author":"Eaton","year":"1982","journal-title":"Science"},{"key":"2019091012220106400_CIT0013","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/infdis\/jiu049","article-title":"Transferrin iron starvation therapy for lethal bacterial and fungal infections","volume":"210","author":"Lin","year":"2014","journal-title":"J Infect Dis"},{"key":"2019091012220106400_CIT0014","doi-asserted-by":"crossref","first-page":"27609","DOI":"10.1074\/jbc.M110.154930","article-title":"Human transferrin confers serum resistance against Bacillus anthracis","volume":"285","author":"Rooijakkers","year":"2010","journal-title":"J Biol Chem"},{"key":"2019091012220106400_CIT0015","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mib.2015.07.005","article-title":"Transferrin-mediated iron sequestration as a novel therapy for bacterial and fungal infections","volume":"27","author":"Bruhn","year":"2015","journal-title":"Curr Opin Microbiol"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiz260\/28791152\/jiz260.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/220\/7\/1147\/29324766\/jiz260.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T17:31:08Z","timestamp":1568136668000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/220\/7\/1147\/5490663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,16]]},"references-count":15,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,5,16]]},"published-print":{"date-parts":[[2019,8,30]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiz260","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,10,1]]},"published":{"date-parts":[[2019,5,16]]}}}