{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:17:58Z","timestamp":1780503478905,"version":"3.54.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:00:00Z","timestamp":1559001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5K12HD028820-22"],"award-info":[{"award-number":["5K12HD028820-22"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Michigan Institute for Clinical and Health Research","award":["UL1TR000433"],"award-info":[{"award-number":["UL1TR000433"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sepsis from Escherichia coli expressing the K1 antigen is a leading cause of death in neonates. In a murine model, E. coli K1 grew rapidly in the peritoneal cavity of neonatal mice, causing fatal disease. In contrast, adult mice cleared the infection. Neonatal mice mounted a rapid and equivalent antimicrobial immune response compared to adult mice. Interestingly, peritoneal fluid from neonatal mice contained significantly more total iron than that of adult mice, which was sufficient to support enhanced E. coli growth. Transient iron overload in adult mice infected with E. coli resulted in 100% mortality. Maternal diet\u2013induced mild iron deficiency decreased offspring peritoneal iron, decreased bacterial growth, and conferred protection against sepsis. Taken together, neonatal susceptibility to E. coli K1 sepsis is enhanced by a localized excess of peritoneal iron that allows for unchecked bacterial growth. Targeting this excess iron may provide a new therapeutic target in human patients.<\/jats:p>","DOI":"10.1093\/infdis\/jiz282","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T19:10:04Z","timestamp":1558725004000},"page":"1219-1229","source":"Crossref","is-referenced-by-count":19,"title":["The Role of Iron in the Susceptibility of Neonatal Mice to Escherichia coli K1 Sepsis"],"prefix":"10.1093","volume":"220","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8227-8238","authenticated-orcid":false,"given":"Kathryn R","family":"Michels","sequence":"first","affiliation":[{"name":"Department of Pathology, Michigan Medicine, School of Public Health, University of Michigan, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie J","family":"Lambrecht","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"IV","given":"William F","family":"Carson","sequence":"first","affiliation":[{"name":"Department of Pathology, Michigan Medicine, School of Public Health, University of Michigan, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A","family":"Schaller","sequence":"first","affiliation":[{"name":"Department of Pathology, Michigan Medicine, School of Public Health, University of Michigan, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas W","family":"Lukacs","sequence":"first","affiliation":[{"name":"Department of Pathology, Michigan Medicine, School of Public Health, University of Michigan, Ann Arbor"},{"name":"Mary H. 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