{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:45:06Z","timestamp":1790163906689,"version":"4.1.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"8","funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,13]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lassa fever is a frequently severe human disease that is endemic to several countries in West Africa. To date, no licensed vaccines are available to prevent Lassa virus (LASV) infection, even though Lassa fever is thought to be an important disease contributing to mortality and both acute and chronic morbidity. We have previously described a vaccine candidate composed of single-cycle LASV replicon particles (VRPs) and a stable cell line for their production. Here, we refine the genetic composition of the VRPs and demonstrate the ability to reproducibly purify them with high yields. Studies in the guinea pig model confirm efficacy of the vaccine candidate, demonstrate that single-cycle replication is necessary for complete protection by the VRP vaccine, and show that postexposure vaccination can confer protection from lethal outcome.<\/jats:p>","DOI":"10.1093\/infdis\/jiz284","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T03:17:56Z","timestamp":1559272676000},"page":"1281-1289","source":"Crossref","is-referenced-by-count":22,"title":["Protection From Lethal Lassa Disease Can Be Achieved Both Before and After Virus Exposure by Administration of Single-Cycle Replicating Lassa Virus Replicon Particles"],"prefix":"10.1093","volume":"220","author":[{"given":"Markus H","family":"Kainulainen","sequence":"first","affiliation":[{"name":"Viral Special Pathogens Branch, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica R","family":"Spengler","sequence":"additional","affiliation":[{"name":"Viral Special Pathogens Branch, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R","family":"Welch","sequence":"additional","affiliation":[{"name":"Viral Special Pathogens Branch, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoAnn D","family":"Coleman-McCray","sequence":"additional","affiliation":[{"name":"Viral Special Pathogens Branch, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica R","family":"Harmon","sequence":"additional","affiliation":[{"name":"Viral Special Pathogens Branch, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florine E M","family":"Scholte","sequence":"additional","affiliation":[{"name":"Viral Special Pathogens Branch, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia S","family":"Goldsmith","sequence":"additional","affiliation":[{"name":"Infectious Diseases Pathology Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart T","family":"Nichol","sequence":"additional","affiliation":[{"name":"Viral Special Pathogens Branch, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar G","family":"Albari\u00f1o","sequence":"additional","affiliation":[{"name":"Viral Special Pathogens Branch, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina F","family":"Spiropoulou","sequence":"additional","affiliation":[{"name":"Viral Special Pathogens Branch, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,6,1]]},"reference":[{"key":"2019091313050156600_CIT0001","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.4269\/ajtmh.1974.23.1131","article-title":"Lassa fever in the Eastern province of Sierra Leone, 1970\u20131972. 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