{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T04:15:36Z","timestamp":1781237736515,"version":"3.54.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T00:00:00Z","timestamp":1569283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["B9RJIXO"],"award-info":[{"award-number":["B9RJIXO"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"French Ministry of Foreign Affairs"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,22]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hemoglobin (Hb) data are limited in Southeast Asian glucose-6-phosphate dehydrogenase (G6PD) deficient (G6PD\u2212) patients treated weekly with the World Health Organization\u2013recommended primaquine regimen (ie, 0.75 mg\/kg\/week for 8 weeks [PQ 0.75]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We treated Cambodians who had acute Plasmodium vivax infection with PQ0.75 and a 3-day course of dihydroartemisinin\/piperaquine and determined the Hb level, reticulocyte count, G6PD genotype, and Hb type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy-five patients (male sex, 63) aged 5\u201363 years (median, 24 years) were enrolled. Eighteen were G6PD deficient (including 17 with G6PD Viangchan) and 57 were not G6PD deficient; 26 had HbE (of whom 25 were heterozygous), and 6 had \u03b1-\/\u03b2-thalassemia. Mean Hb concentrations at baseline (ie, day 0) were similar between G6PD deficient and G6PD normal patients (12.9 g\/dL [range, 9\u201216.3 g\/dL] and 13.26 g\/dL [range, 9.6\u201216 g\/dL], respectively; P = .46). G6PD deficiency (P = &amp;lt;.001), higher Hb concentration at baseline (P = &amp;lt;.001), higher parasitemia level at baseline (P = .02), and thalassemia (P = .027) influenced the initial decrease in Hb level, calculated as the nadir level minus the baseline level (range, \u22125.8\u20130 g\/dL; mean, \u22121.88 g\/dL). By day 14, the mean difference from the day 7 level (calculated as the day 14 level minus the day 7 level) was 0.03 g\/dL (range, \u22120.25\u20120.32 g\/dL). Reticulocyte counts decreased from days 1 to 3, peaking on day 7 (in the G6PD normal group) and day 14 (in the G6PD deficient group); reticulocytemia at baseline (P = .001), G6PD deficiency (P = &amp;lt;.001), and female sex (P = .034) correlated with higher counts. One symptomatic, G6PD-deficient, anemic male patient was transfused on day 4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The first PQ0.75 exposure was associated with the greatest decrease in Hb level and 1 blood transfusion, followed by clinically insignificant decreases in Hb levels. PQ0.75 requires monitoring during the week after treatment. Safer antirelapse regimens are needed in Southeast Asia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trials Registration<\/jats:title><jats:p>ACTRN12613000003774.<\/jats:p><\/jats:sec>","DOI":"10.1093\/infdis\/jiz313","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T19:13:20Z","timestamp":1560885200000},"page":"1750-1760","source":"Crossref","is-referenced-by-count":13,"title":["Hemolytic Dynamics of Weekly Primaquine Antirelapse Therapy Among Cambodians With Acute Plasmodium vivax Malaria With or Without Glucose-6-Phosphate Dehydrogenase Deficiency"],"prefix":"10.1093","volume":"220","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6236-0464","authenticated-orcid":false,"given":"Walter R J","family":"Taylor","sequence":"first","affiliation":[{"name":"National Center for Parasitology, Entomology, and Malaria Control, Phnom Penh, Cambodia"},{"name":"Service de M\u00e9decine Tropicale et Humanitaire, H\u00f4pitaux Universitaires de 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