{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:05:25Z","timestamp":1791893125922,"version":"4.3.4"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["81702560"],"award-info":[{"award-number":["81702560"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Vaginal dysbiosis characterized by depleted lactobacilli is usually correlated with human papillomavirus (HPV) infection and cervical carcinogenesis, but the effect of the Lactobacillus genus and represented species on this process remains unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>PubMed, EMBASE, and CENTRAL databases were searched up to February 15, 2019. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a fixed-effect model and Review Manager (version 5.3) for Mac.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Eleven studies comprising 1230 cases were included. Lactobacillus spp. was associated with the decreased detection of high-risk subtype (hr)HPV infection (OR = 0.64, 95% CI = 0.48\u20130.87, I2 = 6%), cervical intraepithelial neoplasia (CIN) (OR = 0.53, 95% CI = 0.34\u20130.83, I2 = 0%), and cervical cancer (CC) (OR = 0.12, 95% CI = 0.04\u20130.36, I2 = 0%). At the level of Lactobacillus species, Lactobacillus crispatus, but not Lactobacillus iners, was correlated with the decreased detection of hrHPV infection (OR = 0.49, 95% CI = 0.31\u20130.79, I2 = 10%) and CIN (OR = 0.50, 95% CI = 0.29\u20130.88, I2 = 0%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Cervicovaginal Lactobacillus spp. is associated with the decreased detection of hrHPV infection, CIN, and CC; L. crispatus may be the critical protective factor.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiz325","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T14:02:52Z","timestamp":1561471372000},"page":"1243-1254","source":"Crossref","is-referenced-by-count":87,"title":["Associations of Cervicovaginal Lactobacilli With High-Risk Human Papillomavirus Infection, Cervical Intraepithelial Neoplasia, and Cancer: A Systematic Review and Meta-Analysis"],"prefix":"10.1093","volume":"220","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8822-3617","authenticated-orcid":false,"given":"Huiyan","family":"Wang","sequence":"first","affiliation":[{"name":"Laboratory of Microbial Ecosystem, Department of Gynecologic Oncology, Anhui Provincial Cancer Hospital, The First Affiliated Hospital of University of Science and Technology of China (West District), Hefei, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ma","sequence":"additional","affiliation":[{"name":"Laboratory of Microbial Ecosystem, Department of Gynecologic Oncology, Anhui Provincial Cancer Hospital, The First Affiliated Hospital of University of Science and Technology of China (West District), Hefei, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruonan","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Microbial Ecosystem, Department of Gynecologic Oncology, Anhui Provincial Cancer Hospital, The First Affiliated Hospital of University of Science and Technology of China (West District), Hefei, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xixi","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Microbial Ecosystem, Department of Gynecologic Oncology, Anhui Provincial Cancer Hospital, The First Affiliated Hospital of University of Science and Technology of China (West District), Hefei, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Wan","sequence":"additional","affiliation":[{"name":"Laboratory of Microbial Ecosystem, Department of Gynecologic Oncology, Anhui Provincial Cancer Hospital, The First Affiliated Hospital of University of Science and Technology of China (West District), Hefei, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Laboratory of Microbial Ecosystem, Department of Gynecologic Oncology, Anhui Provincial Cancer Hospital, The First Affiliated Hospital of University of Science and Technology of China (West District), Hefei, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,6,27]]},"reference":[{"key":"2019091313051136300_CIT0001","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"2019091313051136300_CIT0002","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F","article-title":"Human papillomavirus is a necessary cause of invasive cervical cancer worldwide","volume":"189","author":"Walboomers","year":"1999","journal-title":"J Pathol"},{"key":"2019091313051136300_CIT0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2018.12.011","article-title":"Vaginal dysbiosis and the risk of human papillomavirus and cervical cancer: systematic review and meta-analysis","author":"Brusselaers","year":"2019; 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