{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T20:09:22Z","timestamp":1762459762604,"version":"3.37.3"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T00:00:00Z","timestamp":1562889600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK49302","K24 HL103845"],"award-info":[{"award-number":["R01DK49302","K24 HL103845"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007299","name":"Harvard Catalyst","doi-asserted-by":"publisher","award":["K23 HL136262","UL1 TR000170","UL1 RR025758","UL1 TR001102"],"award-info":[{"award-number":["K23 HL136262","UL1 TR000170","UL1 RR025758","UL1 TR001102"]}],"id":[{"id":"10.13039\/100007299","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["P30 DK040561"],"award-info":[{"award-number":["P30 DK040561"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Purpose<\/jats:title>\n                  <jats:p>To evaluate the relationship of lipocalin 2 to inflammation and cardiac injury with increased aldosterone in human immunodeficiency virus (HIV).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A standardized 6-day low-sodium diet was used to stimulate renin-angiotensin-aldosterone system (RAAS) activation, and serum lipocalin 2 and biomarkers of inflammation and cardiac stretch were assessed among persons with or without HIV.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Lipocalin 2 levels increased with RAAS activation compared with suppression in the HIV group (median level [interquartile range], 71.3 [59.2\u201399.7] vs 67.0 [51.8\u201386.3] ng\/mL; P = .01). During RAAS activation, lipocalin 2 was related to biomarkers of inflammation (tumor necrosis factor \u03b1 [P = .007]), monocyte\/macrophage activation (soluble CD163 [P = .005] and chemokine [C-C motif] ligand 2 [P = .03]), and markers of cardiac stretch (brain natriuretic peptide [P &lt; .001] and N-terminal fragment of the prohormone brain natriuretic peptide [P = .001]) in HIV.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Lipocalin 2 may be important in modulating aldosterone-induced inflammation, monocyte activation, and cardiac stretch during RAAS activation in HIV.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trial Registration<\/jats:title>\n                  <jats:p>NCT01407237<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiz346","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T23:09:54Z","timestamp":1562800194000},"page":"1420-1424","source":"Crossref","is-referenced-by-count":6,"title":["Serum Lipocalin 2 (Neutrophil Gelatinase\u2013Associated Lipocalin) in Relation to Biomarkers of Inflammation and Cardiac Stretch During Activation of the Renin-Angiotensin-Aldosterone System in Human Immunodeficiency Virus"],"prefix":"10.1093","volume":"220","author":[{"given":"Milana","family":"Bogorodskaya","sequence":"first","affiliation":[{"name":"Division of Infectious Disease, Beth Israel Deaconess Medical Center and Harvard Medical School, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen V","family":"Fitch","sequence":"additional","affiliation":[{"name":"Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tricia H","family":"Burdo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Temple University School of Medicine, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Maehler","sequence":"additional","affiliation":[{"name":"Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca M","family":"Easly","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian R","family":"Murray","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghan","family":"Feldpausch","sequence":"additional","affiliation":[{"name":"Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail K","family":"Adler","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts, 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