{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:53:41Z","timestamp":1790679221512,"version":"4.1.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,7,28]],"date-time":"2019-07-28T00:00:00Z","timestamp":1564272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Financiadora de Estudos e Projetos \u2013 Brazil","award":["0116005600"],"award-info":[{"award-number":["0116005600"]}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior - Brasil","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Pesquisa e Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Congenital Zika syndrome (CZS) is a cluster of malformation, and the mechanisms that lead it are still unclear. Using hypothesis-driven candidate genes and their function in viral infections, single-nucleotide polymorphisms (SNPs) were genotyped by quantitative polymerase chain reaction in a sample population from Sergipe State, Brazil. This study shows that rs3775291 SNP at Toll-like receptor 3, which triggers type I interferon antiviral responses in mothers infected by Zika virus during pregnancy, is associated with CZS occurrence (odds ratio [OR], 2.19; 95% confidence interval [CI], 1.158\u20134.148). Moreover, rs1799964 SNP at tumor necrosis factor-\u03b1 gene in CZS babies is associated with severe microcephaly (OR, 2.63; 95% CI, 1.13\u20136.21).<\/jats:p>","DOI":"10.1093\/infdis\/jiz392","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T15:09:09Z","timestamp":1564153749000},"page":"1797-1801","source":"Crossref","is-referenced-by-count":41,"title":["Association Between Zika Virus Microcephaly in Newborns With the rs3775291 Variant in Toll-Like Receptor 3 and rs1799964 Variant at Tumor Necrosis Factor-\u03b1 Gene"],"prefix":"10.1093","volume":"220","author":[{"given":"Camilla N O","family":"Santos","sequence":"first","affiliation":[{"name":"Molecular Biology Laboratory and Graduate Program in Health Science, Federal University of Sergipe, Aracaju, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle R","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory, University Hospital, Federal University of Sergipe, Aracaju, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Cardoso Alves","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory and Graduate Program in Health Science, Federal University of Sergipe, Aracaju, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo A","family":"Cazzaniga","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory, University Hospital, Federal University of Sergipe, Aracaju, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas S","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory and Graduate Program in Health Science, Federal University of Sergipe, Aracaju, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9rcia S F","family":"de Souza","sequence":"additional","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade de Sergipe, Aracaju, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana B L","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Microcephaly Clinic, Pediatric Division of University Hospital, Federal University of Sergipe, Aracaju, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana J B","family":"Bispo","sequence":"additional","affiliation":[{"name":"Microcephaly Clinic, Pediatric Division of University Hospital, Federal University of Sergipe, Aracaju, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roseane L S","family":"Porto","sequence":"additional","affiliation":[{"name":"Microcephaly Clinic, Pediatric Division of University Hospital, Federal University of Sergipe, Aracaju, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cliomar Alves dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Central Public Health Laboratory of Sergipe, Aracaju, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c2ngela M","family":"da Silva","sequence":"additional","affiliation":[{"name":"Infectious Disease Division of University Hospital, Federal University of Sergipe, Aracaju, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro M","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Immunopharmacology, Federal University of Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roque P","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory and Graduate Program in Health Science, Federal University of Sergipe, Aracaju, Brazil"},{"name":"Department of Medicine of University Hospital, Federal University of Sergipe, Aracaju, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lia R","family":"de 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