{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:34:50Z","timestamp":1792020890146,"version":"4.4.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T00:00:00Z","timestamp":1569283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"MOHLTC Health Systems Research"},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP 130568"],"award-info":[{"award-number":["MOP 130568"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011593","name":"ICES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000226","name":"MOHLTC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008097","name":"University of Toronto Department of Family and Community Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Annual influenza immunization is recommended for people with chronic obstructive pulmonary disease (COPD) by all major COPD clinical practice guidelines. We sought to determine the seasonal influenza vaccine effectiveness (VE) against laboratory-confirmed influenza-associated hospitalizations among older adults with COPD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a test-negative study of influenza VE in community-dwelling older adults with COPD in Ontario, Canada using health administrative data and respiratory specimens collected from patients tested for influenza during the 2010\u201311 to 2015\u201316 influenza seasons. Influenza vaccination was ascertained from physician and pharmacist billing claims. Multivariable logistic regression was used to estimate the adjusted odds ratio of influenza vaccination in people with, compared to those without, laboratory-confirmed influenza.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Receipt of seasonal influenza vaccine was associated with an adjusted 22% (95% confidence interval [CI], 15%\u201327%) reduction in laboratory-confirmed influenza-associated hospitalization. Adjustment for potential misclassification of vaccination status increased this to 43% (95% CI, 35%\u201352%). Vaccine effectiveness was not found to vary by patient- or influenza-related variables.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>During the studied influenza seasons, influenza vaccination was at least modestly effective in reducing laboratory-confirmed influenza-associated hospitalizations in people with COPD. The imperfect effectiveness emphasizes the need for better influenza vaccines and other preventive strategies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiz419","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T15:25:25Z","timestamp":1567178725000},"page":"42-52","source":"Crossref","is-referenced-by-count":29,"title":["Influenza Vaccine Effectiveness in Preventing Hospitalizations in Older Patients With Chronic Obstructive Pulmonary Disease"],"prefix":"10.1093","volume":"221","author":[{"given":"Andrea S","family":"Gershon","sequence":"first","affiliation":[{"name":"Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada"},{"name":"ICES, Toronto, Ontario, Canada"},{"name":"Department of Medicine, University of Toronto, Ontario, Canada"},{"name":"Dalla Lana School of Public Health, University of Toronto, Ontario, Canada"},{"name":"Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Chung","sequence":"additional","affiliation":[{"name":"ICES, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Porter","sequence":"additional","affiliation":[{"name":"ICES, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Campitelli","sequence":"additional","affiliation":[{"name":"ICES, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A","family":"Buchan","sequence":"additional","affiliation":[{"name":"ICES, Toronto, Ontario, Canada"},{"name":"Dalla Lana School of Public Health, University of Toronto, Ontario, Canada"},{"name":"Public Health Ontario, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin L","family":"Schwartz","sequence":"additional","affiliation":[{"name":"ICES, Toronto, Ontario, Canada"},{"name":"Dalla Lana School of Public Health, University of Toronto, Ontario, Canada"},{"name":"Public Health Ontario, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha S","family":"Crowcroft","sequence":"additional","affiliation":[{"name":"Dalla Lana School of Public Health, University of Toronto, Ontario, Canada"},{"name":"Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada"},{"name":"Public Health Ontario, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Campigotto","sequence":"additional","affiliation":[{"name":"Hospital for Sick Children, Toronto, Ontario, Canada"},{"name":"London Health Sciences Centre, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan B","family":"Gubbay","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada"},{"name":"Public Health Ontario, Toronto, Canada"},{"name":"Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Karnauchow","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Eastern Ontario, Ottawa, Canada"},{"name":"Department of Pathology and Laboratory Medicine, University of Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Katz","sequence":"additional","affiliation":[{"name":"North York General Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison J","family":"McGeer","sequence":"additional","affiliation":[{"name":"Dalla Lana School of Public Health, University of Toronto, Ontario, Canada"},{"name":"Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada"},{"name":"Department of Microbiology Sinai Health System, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Dayre","family":"McNally","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Eastern Ontario, Ottawa, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C","family":"Richardson","sequence":"additional","affiliation":[{"name":"William Osler Health System, Brampton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada"},{"name":"Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C","family":"Rosella","sequence":"additional","affiliation":[{"name":"ICES, Toronto, Ontario, Canada"},{"name":"Dalla Lana School of Public Health, University of Toronto, Ontario, Canada"},{"name":"Public Health 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