{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:30:12Z","timestamp":1765888212913,"version":"3.37.3"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"2","funder":[{"DOI":"10.13039\/100000030","name":"CDC","doi-asserted-by":"publisher","award":["200-2002-00610","200-2002-00611","200-2002-00612","200-2002-00613","200-2007-23633","200-2007-23634","200-2007-23635","200-2007-23636"],"award-info":[{"award-number":["200-2002-00610","200-2002-00611","200-2002-00612","200-2002-00613","200-2007-23633","200-2007-23634","200-2007-23635","200-2007-23636"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,29]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High-risk anal human papillomavirus (HPV) infection is prevalent among men living with human immunodeficiency virus (HIV); the association between 9-valent (9v) high-risk HPV (HR-HPV) vaccine types and abnormal cytology has not been well characterized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We followed a prospective cohort study of persons with HIV at 7 HIV clinics in 4 US cities from March 2004 through June 2012. Annually, providers collected separate anal swabs for HPV detection and cytopathologic examination. Among men, we examined prevalence, incidence, and clearance of 9v HR-HPV vaccine types, compared with other HR types, and associations with abnormal cytology to assess potential vaccine impact.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline prevalence of any anal 9v HR-HPV type among men who have sex with men (MSM) and men who have sex with women (MSW) was 74% and 25% (P &amp;lt; .001), respectively. Among 299 MSM, abnormal cytology was detected in 161 (54%) MSM and was associated with the presence of any 9v HR-HPV (relative risk [RR], 1.8 [95% confidence interval {CI}, 1.3\u20132.6]; P &amp;lt; .001). Among 61 MSW, abnormal anal cytology was detected in 12 (20%) and was associated with the presence of any 9v HR-HPV (RR, 4.3 [95% CI, 1.6\u201311.5]; P &amp;lt; .001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among men with HIV, the prevalence of the 7 HR-HPV types in the 9v vaccine was high and was associated with abnormal cytology. These findings indicate that men with HIV could benefit from prophylactic administration of the 9v HPV vaccine.<\/jats:p><\/jats:sec>","DOI":"10.1093\/infdis\/jiz425","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T11:33:44Z","timestamp":1568806424000},"page":"234-242","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence, Incidence, and Clearance of Human Papillomavirus Types Covered by Current Vaccines in Men With Human Immunodeficiency Virus in the SUN Study"],"prefix":"10.1093","volume":"222","author":[{"given":"Pragna","family":"Patel","sequence":"first","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Bush","sequence":"first","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lois","family":"Conley","sequence":"first","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth R","family":"Unger","sequence":"first","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa M","family":"Darragh","sequence":"first","affiliation":[{"name":"University of California, San Francisco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Henry","sequence":"first","affiliation":[{"name":"Hennepin County Medical Center, Minneapolis, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerome","family":"Escota","sequence":"first","affiliation":[{"name":"Washington University School of Medicine, St Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T","family":"Brooks","sequence":"first","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erna Milunka","family":"Kojic","sequence":"first","affiliation":[{"name":"Mount Sinai Hospital, St Luke\u2019s, and West Hospitals, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,9,19]]},"reference":[{"key":"2020062908335430600_CIT0001","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/ijc.30716","article-title":"Worldwide burden of cancer attributable to HPV by site, country and HPV type","volume":"141","author":"de Martel","year":"2017","journal-title":"Int J Cancer"},{"key":"2020062908335430600_CIT0002","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S1473-3099(17)30653-9","article-title":"Human papillomavirus types from infection to cancer in the anus, according to sex and HIV status: a systematic review and meta-analysis","volume":"18","author":"Lin","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"2020062908335430600_CIT0003","doi-asserted-by":"crossref","first-page":"728","DOI":"10.7326\/0003-4819-148-10-200805200-00005","article-title":"Incidence of types of cancer among HIV-infected persons compared with the general population in the United States, 1992-2003","volume":"148","author":"Patel","year":"2008","journal-title":"Ann Intern Med"},{"key":"2020062908335430600_CIT0004","doi-asserted-by":"crossref","first-page":"507","DOI":"10.7326\/M14-2768","article-title":"Cumulative incidence of cancer among persons with HIV in North America: a cohort study","volume":"163","author":"Silverberg","year":"2015","journal-title":"Ann Intern Med"},{"key":"2020062908335430600_CIT0005","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s11908-010-0090-7","article-title":"Evaluation and management of anal intraepithelial neoplasia in HIV-negative and HIV-positive men who have sex with men","volume":"12","author":"Park","year":"2010","journal-title":"Curr Infect Dis Rep"},{"key":"2020062908335430600_CIT0006","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1097\/QAD.0b013e328360a509","article-title":"High prevalence and incidence of high-grade anal intraepithelial neoplasia among young Thai men who have sex with men with and without HIV","volume":"27","author":"Phanuphak","year":"2013","journal-title":"AIDS"},{"key":"2020062908335430600_CIT0007","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1200\/JCO.2017.74.9291","article-title":"Anal cancer risk among people with HIV infection in the United States","volume":"36","author":"Col\u00f3n-L\u00f3pez","year":"2018","journal-title":"J Clin Oncol"},{"key":"2020062908335430600_CIT0008","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S1470-2045(12)70080-3","article-title":"Anal human papillomavirus infection and associated neoplastic lesions in men who have sex with men: a systematic review and meta-analysis","volume":"13","author":"Machalek","year":"2012","journal-title":"Lancet Oncol"},{"key":"2020062908335430600_CIT0009","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1086\/597207","article-title":"Prevalence, clearance, and incidence of anal human papillomavirus infection in HIV-infected men: the HIPVIRG cohort study","volume":"199","author":"de Pokomandy","year":"2009","journal-title":"J Infect Dis"},{"key":"2020062908335430600_CIT0010","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/cncr.20365","article-title":"Human papillomavirus, smoking, and sexual practices in the etiology of anal cancer","volume":"101","author":"Daling","year":"2004","journal-title":"Cancer"},{"key":"2020062908335430600_CIT0011","first-page":"1014","article-title":"Detection of human papillomavirus DNA in anal intraepithelial neoplasia and anal cancer","volume":"51","author":"Palefsky","year":"1991","journal-title":"Cancer Res"},{"key":"2020062908335430600_CIT0012","doi-asserted-by":"crossref","first-page":"6356","DOI":"10.1016\/j.vaccine.2014.09.033","article-title":"HPV vaccine coverage among men who have sex with men\u2014National HIV Behavioral Surveillance System, United States, 2011","volume":"32","author":"Meites","year":"2014","journal-title":"Vaccine"},{"key":"2020062908335430600_CIT0013","first-page":"300","article-title":"Use of 9-valent human papillomavirus (HPV) vaccine: updated HPV vaccination recommendations of the Advisory Committee on Immunization Practices","volume":"64","author":"Centers for Disease Control and Prevention","year":"2015","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2020062908335430600_CIT0014","first-page":"241","article-title":"Human papillomavirus vaccines. WHO position paper, May 2017","volume":"92","author":"World Health Organization","year":"2017","journal-title":"Wkly Epidemiol Rec"},{"volume-title":"Gardasil (October 22, 2018)","author":"US Food and Drug Administration","key":"2020062908335430600_CIT0015"},{"key":"2020062908335430600_CIT0016","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1093\/cid\/ciy274","article-title":"A randomized placebo-controlled trial of the quadrivalent human papillomavirus vaccine in human immunodeficiency virus-infected adults aged 27 years or older: AIDS Clinical Trials Group protocol A5298","volume":"67","author":"Wilkin","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2020062908335430600_CIT0017","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1093\/aje\/kwn361","article-title":"The study to understand the natural history of HIV and AIDS in the era of effective therapy (SUN Study)","volume":"169","author":"Vellozzi","year":"2009","journal-title":"Am J Epidemiol"},{"key":"2020062908335430600_CIT0018","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1001\/jama.287.16.2114","article-title":"The 2001 Bethesda System: terminology for reporting results of cervical cytology","volume":"287","author":"Solomon","year":"2002","journal-title":"JAMA"},{"key":"2020062908335430600_CIT0019","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1093\/infdis\/jiy087","article-title":"Prevalence and incidence of anal and cervical high-risk human papillomavirus (HPV) types covered by current HPV vaccines among HIV-infected women in the SUN study","volume":"217","author":"Kojic","year":"2018","journal-title":"J Infect Dis"},{"key":"2020062908335430600_CIT0020","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/infdis\/jix607","article-title":"Prevalence, incidence, and clearance of anal high-risk human papillomavirus infection among HIV-infected men in the SUN study","volume":"217","author":"Patel","year":"2018","journal-title":"J Infect Dis"},{"key":"2020062908335430600_CIT0021","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.pvr.2015.09.001","article-title":"An analysis of HPV infection incidence and clearance by genotype and age in men: the HPV infection in men (HIM) study","volume":"1","author":"Ingles","year":"2015","journal-title":"Papillomavirus Res"},{"key":"2020062908335430600_CIT0022","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1097\/QAD.0000000000000254","article-title":"Incidence of and risk factors for type-specific anal human papillomavirus infection among HIV-positive MSM","volume":"28","author":"Hernandez","year":"2014","journal-title":"AIDS"},{"key":"2020062908335430600_CIT0023","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1097\/QAD.0000000000001546","article-title":"Impact of screening and antiretroviral therapy on anal cancer incidence in HIV-positive MSM","volume":"31","author":"Blaser","year":"2017","journal-title":"AIDS"},{"key":"2020062908335430600_CIT0024","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/cyt.12259","article-title":"Evaluating cytology for the detection of invasive cervical cancer","volume":"27","author":"Landy","year":"2016","journal-title":"Cytopathology"},{"key":"2020062908335430600_CIT0025","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/QCO.0000000000000337","article-title":"Human papillomavirus as a cause of anal cancer and the role of screening","volume":"30","author":"Gosens","year":"2017","journal-title":"Curr Opin Infect Dis"},{"key":"2020062908335430600_CIT0026","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1128\/JCM.01405-13","article-title":"Anal human papillomavirus genotype distribution in HIV-infected men who have sex with men by geographical origin, age, and cytological status in a Spanish cohort","volume":"51","author":"Torres","year":"2013","journal-title":"J Clin Microbiol"},{"key":"2020062908335430600_CIT0027","doi-asserted-by":"crossref","first-page":"djv086","DOI":"10.1093\/jnci\/djv086","article-title":"US assessment of HPV types in cancers: implications for current and 9-valent HPV vaccines","volume":"107","author":"Saraiya","year":"2015","journal-title":"J Natl Cancer Inst"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiz425\/30037535\/jiz425.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/222\/2\/234\/33441934\/jiz425.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/222\/2\/234\/33441934\/jiz425.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T05:21:55Z","timestamp":1611206515000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/222\/2\/234\/5571724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,19]]},"references-count":27,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,9,19]]},"published-print":{"date-parts":[[2020,6,29]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiz425","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"type":"print","value":"0022-1899"},{"type":"electronic","value":"1537-6613"}],"subject":[],"published-other":{"date-parts":[[2020,7,15]]},"published":{"date-parts":[[2019,9,19]]}}}