{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T08:10:46Z","timestamp":1775981446409,"version":"3.50.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T00:00:00Z","timestamp":1566259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Department of Defense Global Emerging Infection Surveillance","award":["P0220_13_OT"],"award-info":[{"award-number":["P0220_13_OT"]}]},{"name":"Department of Medicine of SUNY Upstate Medical University"},{"name":"Division of Nutritional Sciences"},{"DOI":"10.13039\/100000179","name":"Office of the Director","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000179","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000124","name":"Office of Research on Women's Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000124","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["R01 EB021331"],"award-info":[{"award-number":["R01 EB021331"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Micronutrients are known to modulate host immunity, and there is limited literature on this association in the context of dengue virus infection (DENV).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Using a nested case-control design in a surveillance program, we measured the following: anthropometry; nutritional biomarkers including serum ferritin, soluble transferrin receptor, retinol-binding protein (RBP), 25-hydroxy vitamin D, folate, and vitamin B12; and a panel of immune response markers. We then compared these measures across 4 illness categories: healthy control, nonfebrile DENV, other febrile illness (OFI), and apparent DENV using multivariate polytomous logistic regression models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 142 participants, serum ferritin (ng\/mL) was associated with apparent DENV compared to healthy controls (odds ratio [OR], 2.66; confidence interval [CI], 1.53\u20134.62; P = .001), and RBP concentrations (\u00b5mol\/L) were associated with apparent DENV (OR, 0.03; CI, 0.00\u20130.30; P = .003) and OFI (OR, 0.02; CI, 0.00\u20130.24; P = .003). In a subset of 71 participants, interleukin-15 levels (median fluorescent intensity) were positively associated with apparent DENV (OR, 1.09; CI, 1.03\u20131.14; P = .001) and negatively associated with nonfebrile DENV (OR, 0.89; CI, 0.80\u20130.99; P = .03) compared to healthy controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>After adjusting for the acute-phase response, serum ferritin and RBP concentrations were associated with apparent DENV and may represent biomarkers of clinical importance in the context of dengue illness.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiz427","type":"journal-article","created":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T11:31:57Z","timestamp":1566041517000},"page":"91-101","source":"Crossref","is-referenced-by-count":10,"title":["Micronutrients, Immunological Parameters, and Dengue Virus Infection in Coastal Ecuador: A Nested Case-Control Study in an Infectious Disease Surveillance Program"],"prefix":"10.1093","volume":"221","author":[{"given":"Julia L","family":"Finkelstein","sequence":"first","affiliation":[{"name":"Division of Nutritional Sciences, Cornell University, Ithaca, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1935-4197","authenticated-orcid":false,"given":"Susannah","family":"Colt","sequence":"additional","affiliation":[{"name":"Division of Nutritional Sciences, Cornell University, Ithaca, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander J","family":"Layden","sequence":"additional","affiliation":[{"name":"Division of Nutritional Sciences, Cornell University, Ithaca, New York"},{"name":"University of Pittsburgh School of Medicine, Pennyslvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse T","family":"Krisher","sequence":"additional","affiliation":[{"name":"Division of Nutritional Sciences, Cornell University, Ithaca, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M","family":"Stewart-Ibarra","sequence":"additional","affiliation":[{"name":"Department of Medicine and Center for Global Health and Translational Science, SUNY Upstate Medical University, Syracuse, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Polhemus","sequence":"additional","affiliation":[{"name":"Department of Medicine and Center for Global Health and Translational Science, SUNY Upstate Medical University, Syracuse, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efra\u00edn","family":"Beltr\u00e1n-Ayala","sequence":"additional","affiliation":[{"name":"Ministry of Health, Machala, El Oro, Ecuador"},{"name":"Department of Medicine, Technical University of Machala, El Oro, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia M","family":"Tedesco","sequence":"additional","affiliation":[{"name":"Division of Nutritional Sciences, Cornell University, Ithaca, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Washington B","family":"C\u00e1rdenas","sequence":"additional","affiliation":[{"name":"Escuela Superior Polit\u00e9cnica del Litoral, Laboratorio para Investigaciones Biom\u00e9dicas, Guayaquil, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Endy","sequence":"additional","affiliation":[{"name":"Department of Medicine and Center for Global Health and Translational Science, SUNY Upstate Medical University, Syracuse, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3788-0665","authenticated-orcid":false,"given":"Saurabh","family":"Mehta","sequence":"additional","affiliation":[{"name":"Division of Nutritional 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