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A minority of infants with cCMV will have symptoms at birth. Infants with symptomatic cCMV are at higher risk for sequelae than those born without symptoms. The majority of infants with cCMV are asymptomatic at birth, but 10%\u201315% will develop hearing loss. Although clinical symptoms can help predict which infants will have sensorineural hearing loss, among asymptomatic cCMV there are currently no predictors of adverse outcome. The identification of a biomarker to identify those at highest risk of sequelae is highly desirable to target interventions to those who could potentially benefit. Because there is increasing rationale for establishing both targeted and universal screening programs for cCMV in the United States and worldwide, this is an urgent priority.<\/jats:p>","DOI":"10.1093\/infdis\/jiz446","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T19:25:25Z","timestamp":1567193125000},"page":"S9-S14","source":"Crossref","is-referenced-by-count":76,"title":["Congenital Cytomegalovirus Infection"],"prefix":"10.1093","volume":"221","author":[{"given":"Nazia","family":"Kabani","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon A","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA"},{"name":"Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, 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