{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:19:24Z","timestamp":1790900364112,"version":"4.1.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T00:00:00Z","timestamp":1572652800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Innovative approaches are needed to limit antimalarial resistance evolution. Understanding the role of intermittent preventive treatment in pregnancy (IPTp) on the selection for resistance and the impact such selection has on pregnancy outcomes can guide future interventions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Plasmodium falciparum isolates (n = 914) from 2 randomized clinical trials were screened for pfmdr1 copy number variation and pfcrt, pfmdr1, pfdhfr, and pfdhps resistance markers. The trials were conducted between 2010 and 2013 in Benin, Gabon, Kenya, and Mozambique to establish the efficacy of IPTp-mefloquine (MQ) compared with IPTp-sulphadoxine-pyrimethamine (SP) in human immunodeficiency virus (HIV)-uninfected and to IPTp-placebo in HIV-infected women.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In HIV-uninfected women, the prevalence of pfcrt mutants, pfdhfr\/pfdhps quintuple mutants, and pfmdr1 copy number was similar between women receiving IPT-SP and IPTp-MQ. However, prevalence of pfmdr1 polymorphism 86Y was lower in the IPTp-MQ group than in the IPTp-SP group, and within the IPTp-MQ group it was lower at delivery compared with recruitment. No effect of IPTp-MQ on resistance markers was observed among HIV-infected women. The carriage of resistance markers was not associated with pregnancy outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Selection of wild-type pfmdr1 polymorphism N86 by IPTp-MQ highlights the strong selective pressure IPTp can exert and the opportunity for using negative cross-resistance in drug choice for clinical treatment and IPTp.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiz451","type":"journal-article","created":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T15:26:06Z","timestamp":1568906766000},"source":"Crossref","is-referenced-by-count":2,"title":["Counter-Selection of Antimalarial Resistance Polymorphisms by Intermittent Preventive Treatment in Pregnancy"],"prefix":"10.1093","author":[{"given":"Silvie","family":"Huijben","sequence":"first","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic - Universitat de Barcelona, Barcelona, Spain"},{"name":"Center for Evolution and Medicine, School of Life Sciences, Arizona State University, Tempe, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eusebio","family":"Macete","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade da Manhi\u00e7a, Manhi\u00e7a, Mozambique"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghyslain","family":"Mombo-Ngoma","sequence":"additional","affiliation":[{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, Lambar\u00e9n\u00e9, Gabon"},{"name":"Institut f\u00fcr Tropenmedizin, Universit\u00e4t T\u00fcbingen, und Deutsches Zentrum f\u00fcr Infektionsforschung, T\u00fcbingen, Germany"},{"name":"Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine and Department of Medicine I, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9259-1885","authenticated-orcid":false,"given":"Michael","family":"Ramharter","sequence":"additional","affiliation":[{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, Lambar\u00e9n\u00e9, Gabon"},{"name":"Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine and Department of Medicine I, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Kariuki","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute\/Centre for Global Health Research, Kisumu, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghna","family":"Desai","sequence":"additional","affiliation":[{"name":"Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya Ping","family":"Shi","sequence":"additional","affiliation":[{"name":"Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Mwangoka","sequence":"additional","affiliation":[{"name":"Ifakara Health Institute, Bagamoyo, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achille","family":"Massougbodji","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d\u2019Enseignement et de Recherche de Parasitologie Mycologie, Facult\u00e9 des Sciences de la Sant\u00e9, Cotonou, B\u00e9nin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Cot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, MERIT, IRD, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicaise Tuikue","family":"Ndam","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, MERIT, IRD, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefania","family":"Uberegui","sequence":"additional","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic - 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