{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T11:34:03Z","timestamp":1793705643699,"version":"4.5.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T00:00:00Z","timestamp":1570060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Levels of antibodies induced by the measles virus\u2013containing vaccine have been shown to decline over time, but there is no formal recommendation about testing immunized subjects (in particular, healthcare workers [HCWs]) to investigate the persistence of measles immunoglobulin G (IgG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study aims to evaluate the long-term immunogenicity of measles vaccine in a sample of medical students and residents of the University of Bari who attended the Hygiene Department for a biological risk assessment (April 2014\u2013June 2018).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two thousand immunized (2 doses of measles-mumps-rubella [MMR] vaccine) students and residents were tested; 305 of these (15%) did not show protective anti-measles IgG. This proportion was higher among subjects who received vaccination at \u226415 months (20%) than in those who received vaccination at 16\u201323 months (17%) and at \u226524 months (10%) (P &amp;lt; .0001). After an MMR vaccine booster dose, we noted a seroconversion of 74% of seronegative HCWs. The overall seroconversion rate after a second dose (booster) was 93%. No serious adverse events were noted after the booster doses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>An important proportion of subjects immunized for measles do not show a protective IgG titer in the 10 years after vaccination. Our management strategy seems consistent with the purpose of evidencing immunological memory.<\/jats:p><\/jats:sec>","DOI":"10.1093\/infdis\/jiz508","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T04:04:42Z","timestamp":1569902682000},"page":"721-728","source":"Crossref","is-referenced-by-count":48,"title":["Long-term Immunogenicity of Measles Vaccine: An Italian Retrospective Cohort Study"],"prefix":"10.1093","volume":"221","author":[{"given":"Francesco Paolo","family":"Bianchi","sequence":"first","affiliation":[{"name":"Department of Biomedical Science and Human Oncology, Aldo Moro University of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Stefanizzi","sequence":"first","affiliation":[{"name":"Department of Biomedical Science and Human Oncology, Aldo Moro University of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"De Nitto","sequence":"first","affiliation":[{"name":"Department of Biomedical Science and Human Oncology, Aldo Moro University of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Maria Vittoria","family":"Larocca","sequence":"first","affiliation":[{"name":"Hygiene Department, Bari Policlinico General Hospital, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Germinario","sequence":"first","affiliation":[{"name":"Department of Biomedical Science and Human Oncology, Aldo Moro University of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Tafuri","sequence":"first","affiliation":[{"name":"Department of Biomedical Science and Human Oncology, Aldo Moro University of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,10,3]]},"reference":[{"key":"2020021806192588000_CIT0001","author":"World Health Organization"},{"key":"2020021806192588000_CIT0002","author":"Centers for Disease Control and Prevention"},{"key":"2020021806192588000_CIT0003","author":"Centers for Disease Control and Prevention"},{"key":"2020021806192588000_CIT0004","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1086\/378987","article-title":"An economic analysis of the current universal 2-dose measles-mumps-rubella vaccination program in the United States","volume":"189","author":"Zhou","year":"2004","journal-title":"J Infect Dis"},{"key":"2020021806192588000_CIT0005","first-page":"649","article-title":"Progress towards regional measles elimination\u2014worldwide, 2000\u20132016","volume":"92","author":"Dabbagh","year":"2017","journal-title":"Wkly Epidemiol Rec"},{"key":"2020021806192588000_CIT0006","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/eurpub\/ckq134","article-title":"Progress towards measles and rubella elimination in Tuscany, Italy: the role of population seroepidemiological profile","volume":"22","author":"Bechini","year":"2012","journal-title":"Eur J Public Health"},{"key":"2020021806192588000_CIT0007","author":"European Centre for Disease Prevention and Control"},{"key":"2020021806192588000_CIT0008","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2018.23.22.1800238","article-title":"Introduction of new and reinforcement of existing compulsory vaccinations in Italy: first evaluation of the impact on vaccination coverage in 2017","volume":"23","author":"D\u2019Ancona","year":"2018","journal-title":"Euro Surveill"},{"key":"2020021806192588000_CIT0009","doi-asserted-by":"crossref","first-page":"30597","DOI":"10.2807\/1560-7917.ES.2017.22.33.30597","article-title":"A nosocomial measles outbreak in Italy, February\u2013April 2017","volume":"22","author":"Porretta","year":"2017","journal-title":"Euro Surveill"},{"key":"2020021806192588000_CIT0010","unstructured":"World Health Organization European Region. 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