{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:24:56Z","timestamp":1783574696733,"version":"3.55.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T00:00:00Z","timestamp":1573689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Departamento de Ci\u00eancia e Tecnologia, Secretaria de Ci\u00eancia e Tecnologia, Minist\u00e9rio da Sa\u00fade, Brazil","award":["25029.000507\/2013-07"],"award-info":[{"award-number":["25029.000507\/2013-07"]}]},{"DOI":"10.13039\/100000060","name":"National Institutes of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["U01-AI069923"],"award-info":[{"award-number":["U01-AI069923"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"National Institutes of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["K01-AI131895"],"award-info":[{"award-number":["K01-AI131895"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["TL1TR000447"],"award-info":[{"award-number":["TL1TR000447"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Weight change may inform tuberculosis treatment response, but its predictive power may be confounded by human immunodeficiency virus (HIV).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We prospectively followed up adults with culture-confirmed, drug-susceptible, pulmonary tuberculosis receiving standard 4-drug therapy (isoniazid, rifampin, pyrazinamide, and ethambutol) in Brazil. We examined median weight change 2 months after treatment initiation by HIV status, using quantile regression, and unsuccessful tuberculosis treatment outcome (treatment failure, tuberculosis recurrence, or death) by HIV and weight change status, using Cox regression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 547 participants, 102 (19%) were HIV positive, and 35 (6%) had an unsuccessful outcome. After adjustment for confounders, persons living with HIV (PLWH) gained a median of 1.3 kg (95% confidence interval [CI], \u22122.8 to .1) less than HIV-negative individuals during the first 2 months of tuberculosis treatment. PLWH were at increased risk of an unsuccessful outcome (adjusted hazard ratio, 4.8; 95% CI, 2.1\u201310.9). Weight change was independently associated with outcome, with risk of unsuccessful outcome decreasing by 12% (95% CI, .81%\u2013.95%) per 1-kg increase.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>PLWH gained less weight during the first 2 months of tuberculosis treatment, and lack of weight gain and HIV independently predicted unsuccessful tuberculosis treatment outcomes. Weight, an easily collected biomarker, may identify patients who would benefit from alternative treatment strategies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiz595","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T04:20:06Z","timestamp":1573532406000},"page":"1416-1424","source":"Crossref","is-referenced-by-count":11,"title":["Lack of Weight Gain During the First 2 Months of Treatment and Human Immunodeficiency Virus Independently Predict Unsuccessful Treatment Outcomes in Tuberculosis"],"prefix":"10.1093","volume":"221","author":[{"given":"Lauren S","family":"Peetluk","sequence":"first","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter F","family":"Rebeiro","sequence":"first","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt 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Nashville, Tennessee, USA"},{"name":"Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Instituto Brasileiro para Investiga\u00e7\u00e3o da Tuberculose, Funda\u00e7\u00e3o Jos\u00e9 Silveira, Salvador, Bahia, Brazil"},{"name":"Instituto Gon\u00e7alo Moniz, Funda\u00e7\u00e3o Oswaldo Cruz, Salvador, Bahia, Brazil"},{"name":"Universidade Salvador (UNIFACS), Laureate Universities, Salvador, Bahia, Brazil"},{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betina","family":"Durovni","sequence":"first","affiliation":[{"name":"Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solange","family":"Calvacante","sequence":"first","affiliation":[{"name":"Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Brazil"},{"name":"Secretaria Municipal de Sa\u00fade do Rio de Janeiro (Cl\u00ednica da Familia Rinaldo Delamare)\u2013Rocinha, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda B","family":"Arriaga","sequence":"first","affiliation":[{"name":"Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Instituto Brasileiro para Investiga\u00e7\u00e3o da Tuberculose, Funda\u00e7\u00e3o Jos\u00e9 Silveira, Salvador, Bahia, Brazil"},{"name":"Instituto Gon\u00e7alo Moniz, Funda\u00e7\u00e3o Oswaldo Cruz, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan M","family":"Turner","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina 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