{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:28:19Z","timestamp":1785900499730,"version":"3.56.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T00:00:00Z","timestamp":1574467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["HHSN272200900010C"],"award-info":[{"award-number":["HHSN272200900010C"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI068632"],"award-info":[{"award-number":["UM1AI068632"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI068616"],"award-info":[{"award-number":["UM1AI068616"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI106716"],"award-info":[{"award-number":["UM1AI106716"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5P30 AI064518"],"award-info":[{"award-number":["5P30 AI064518"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HHSN275201800001I"],"award-info":[{"award-number":["HHSN275201800001I"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR002535"],"award-info":[{"award-number":["UL1 TR002535"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006967","name":"Duke University Center for AIDS Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006967","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The safety and immunogenicity of live respiratory syncytial virus (RSV) candidate vaccine, LID\/\u0394M2-2\/1030s, with deletion of RSV ribonucleic acid synthesis regulatory protein M2-2 and genetically stabilized temperature-sensitivity mutation 1030s in the RSV polymerase protein was evaluated in RSV-seronegative children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Respiratory syncytial virus-seronegative children ages 6\u201324 months received 1 intranasal dose of 105 plaque-forming units (PFU) of LID\/\u0394M2-2\/1030s (n = 21) or placebo (n = 11). The RSV serum antibodies, vaccine shedding, and reactogenicity were assessed. During the following RSV season, medically attended acute respiratory illness (MAARI) and pre- and postsurveillance serum antibody titers were monitored.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Eighty-five percent of vaccinees shed LID\/\u0394M2-2\/1030s vaccine (median peak nasal wash titers: 3.1 log10 PFU\/mL by immunoplaque assay; 5.1 log10 copies\/mL by reverse-transcription quantitative polymerase chain reaction) and had \u22654-fold rise in serum-neutralizing antibodies. Respiratory symptoms and fever were common (60% vaccinees and 27% placebo recipients). One vaccinee had grade 2 wheezing with rhinovirus but without concurrent LID\/\u0394M2-2\/1030s shedding. Five of 19 vaccinees had \u22654-fold increases in antibody titers postsurveillance without RSV-MAARI, indicating anamnestic responses without significant illness after infection with community-acquired RSV.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>LID\/\u0394M2-2\/1030s had excellent infectivity without evidence of genetic instability, induced durable immunity, and primed for anamnestic antibody responses, making it an attractive candidate for further evaluation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiz603","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T07:08:58Z","timestamp":1573628938000},"page":"534-543","source":"Crossref","is-referenced-by-count":51,"title":["Live Respiratory Syncytial Virus Attenuated by M2-2 Deletion and Stabilized Temperature Sensitivity Mutation 1030s Is a Promising Vaccine Candidate in Children"],"prefix":"10.1093","volume":"221","author":[{"given":"Elizabeth J","family":"McFarland","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Colorado Anschutz Medical Campus and Children\u2019s Hospital Colorado, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth A","family":"Karron","sequence":"additional","affiliation":[{"name":"Center for Immunization Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petronella","family":"Muresan","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health\/Frontier Science, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coleen K","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Libous","sequence":"additional","affiliation":[{"name":"FHI 360, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Perlowski","sequence":"additional","affiliation":[{"name":"FHI 360, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhagvanji","family":"Thumar","sequence":"additional","affiliation":[{"name":"Center for Immunization Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devasena","family":"Gnanashanmugam","sequence":"additional","affiliation":[{"name":"Maternal, Adolescent and Pediatric Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Jack","family":"Moye","sequence":"additional","affiliation":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Schappell","sequence":"additional","affiliation":[{"name":"Center for Immunization Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Barr","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Colorado Anschutz Medical Campus and Children\u2019s Hospital Colorado, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Rexroad","sequence":"additional","affiliation":[{"name":"Investigational Drug Service Pharmacy, Johns Hopkins Hospital, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Fearn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Northwestern University Medical School and Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A","family":"Spector","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California San Diego, La Jolla, California, USA"},{"name":"Rady Children\u2019s Hospital, San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Aziz","sequence":"additional","affiliation":[{"name":"Section of Infectious Disease, Rush University Medical Center, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhaela","family":"Cielo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Maternal Child and Adolescent Center, University of Southern California Keck School of Medicine, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christy","family":"Beneri","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, SUNY Stony Brook, Stony Brook, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Wiznia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Albert Einstein College of Medicine and Jacobi Medical Center, Bronx, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Luongo","sequence":"additional","affiliation":[{"name":"Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Collins","sequence":"additional","affiliation":[{"name":"Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula J","family":"Buchholz","sequence":"additional","affiliation":[{"name":"Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,11,23]]},"reference":[{"key":"2020020313030269700_CIT0001","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/S0140-6736(17)30938-8","article-title":"Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study","volume":"390","author":"Shi","year":"2017","journal-title":"Lancet"},{"key":"2020020313030269700_CIT0002","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0140-6736(17)31476-9","article-title":"Determining the burden of respiratory syncytial virus disease: the known and the unknown","volume":"390","author":"Karron","year":"2017","journal-title":"Lancet"},{"key":"2020020313030269700_CIT0003","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1164\/rccm.201603-0658OC","article-title":"Mortality due to respiratory syncytial virus. burden and risk factors","volume":"195","author":"Geoghegan","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"2020020313030269700_CIT0004","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1067\/mpd.2000.110531","article-title":"Rates of hospitalization for respiratory syncytial virus infection among children in medicaid","volume":"137","author":"Boyce","year":"2000","journal-title":"J Pediatr"},{"key":"2020020313030269700_CIT0005","doi-asserted-by":"crossref","first-page":"7315","DOI":"10.1016\/j.vaccine.2016.10.090","article-title":"Report from","volume":"37","author":"Giersing","year":"2019","journal-title":"Vaccine"},{"key":"2020020313030269700_CIT0006","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1016\/j.vaccine.2016.04.083","article-title":"Vaccines against respiratory syncytial virus: the time has finally come","volume":"34","author":"Graham","year":"2016","journal-title":"Vaccine"},{"key":"2020020313030269700_CIT0007","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1097\/01.inf.0000108194.71892.95","article-title":"The future of respiratory syncytial virus vaccine development","volume":"23","author":"Polack","year":"2004","journal-title":"Pediatr Infect Dis J"},{"key":"2020020313030269700_CIT0008","first-page":"259","article-title":"Live-attenuated respiratory syncytial virus vaccines","volume":"372","author":"Karron","year":"2013","journal-title":"Curr Top Microbiol Immunol"},{"key":"2020020313030269700_CIT0009","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1093\/oxfordjournals.aje.a120955","article-title":"Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine","volume":"89","author":"Kim","year":"1969","journal-title":"Am J Epidemiol"},{"key":"2020020313030269700_CIT0010","first-page":"233","article-title":"Vaccines against human respiratory syncytial virus.","volume-title":"Perspectives in Medical Virology","author":"Collins","year":"2006"},{"key":"2020020313030269700_CIT0011","doi-asserted-by":"crossref","first-page":"7372","DOI":"10.1016\/j.vaccine.2007.08.014","article-title":"The absence of enhanced disease with wild type respiratory syncytial virus infection occurring after receipt of live, attenuated, respiratory syncytial virus vaccines","volume":"25","author":"Wright","year":"2007","journal-title":"Vaccine"},{"key":"2020020313030269700_CIT0012","doi-asserted-by":"crossref","first-page":"e02180","DOI":"10.1128\/JVI.02180-16","article-title":"Immunization with low doses of recombinant postfusion or prefusion respiratory syncytial virus f primes for vaccine-enhanced disease in the cotton rat model independently of the presence of a Th1-biasing (GLA-SE) or Th2-biasing (Alum) adjuvant","volume":"91","author":"Schneider-Ohrum","year":"2017","journal-title":"J Virol"},{"key":"2020020313030269700_CIT0013","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3201\/eid0602.000204","article-title":"Vaccines for mucosal immunity to combat emerging infectious diseases","volume":"6","author":"Frederik","year":"2000","journal-title":"Emerging Infect Dis J"},{"key":"2020020313030269700_CIT0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.0300-9475.2004.01382.x","article-title":"Influenza virus: immunity and vaccination strategies. Comparison of the immune response to inactivated and live, attenuated influenza vaccines","volume":"59","author":"Cox","year":"2004","journal-title":"Scand J Immunol"},{"key":"2020020313030269700_CIT0015","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.2165\/11206860-000000000-00000","article-title":"Live attenuated influenza vaccine (FluMist\u00ae; Fluenz\u2122): a review of its use in the prevention of seasonal influenza in children and adults","volume":"71","author":"Carter","year":"2011","journal-title":"Drugs"},{"key":"2020020313030269700_CIT0016","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/infdis\/jir436","article-title":"Live and inactivated influenza vaccines induce similar humoral responses, but only live vaccines induce diverse T-cell responses in young children","volume":"204","author":"Hoft","year":"2011","journal-title":"J Infect Dis"},{"key":"2020020313030269700_CIT0017","doi-asserted-by":"crossref","first-page":"11563","DOI":"10.1073\/pnas.92.25.11563","article-title":"Production of infectious human respiratory syncytial virus from cloned cDNA confirms an essential role for the transcription elongation factor from the 5\u2019 proximal open reading frame of the M2 mRNA in gene expression and provides a capability for vaccine development","volume":"92","author":"Collins","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020020313030269700_CIT0018","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.virusres.2011.09.020","article-title":"Progress in understanding and controlling respiratory syncytial virus: still crazy after all these years","volume":"162","author":"Collins","year":"2011","journal-title":"Virus Res"},{"key":"2020020313030269700_CIT0019","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1086\/315859","article-title":"Evaluation of a live, cold-passaged, temperature-sensitive, respiratory syncytial virus vaccine candidate in infancy","volume":"182","author":"Wright","year":"2000","journal-title":"J Infect Dis"},{"key":"2020020313030269700_CIT0020","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1086\/427813","article-title":"Identification of a recombinant live attenuated respiratory syncytial virus vaccine candidate that is highly attenuated in infants","volume":"191","author":"Karron","year":"2005","journal-title":"J Infect Dis"},{"key":"2020020313030269700_CIT0021","doi-asserted-by":"crossref","first-page":"312ra175","DOI":"10.1126\/scitranslmed.aac8463","article-title":"A gene deletion that up-regulates viral gene expression yields an attenuated RSV vaccine with improved antibody responses in children","volume":"7","author":"Karron","year":"2015","journal-title":"Science Transl Med"},{"key":"2020020313030269700_CIT0022","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1093\/infdis\/jiy040","article-title":"Live-attenuated respiratory syncytial virus vaccine candidate with deletion of RNA synthesis regulatory protein M2-2 is highly immunogenic in children","volume":"217","author":"McFarland","year":"2018","journal-title":"J Infect Dis"},{"key":"2020020313030269700_CIT0023","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1093\/infdis\/jiy066","article-title":"Live respiratory syncytial virus (RSV) vaccine candidate containing stabilized temperature-sensitivity mutations is highly attenuated in RSV-seronegative infants and children","volume":"217","author":"Buchholz","year":"2018","journal-title":"J Infect Dis"},{"key":"2020020313030269700_CIT0024","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1099\/0022-1317-71-12-3015","article-title":"The two open reading frames of the 22K mRNA of human respiratory syncytial virus: sequence comparison of antigenic subgroups A and B and expression in vitro","volume":"71 (Pt 12)","author":"Collins","year":"1990","journal-title":"J Gen Virol"},{"key":"2020020313030269700_CIT0025","doi-asserted-by":"crossref","first-page":"11259","DOI":"10.1073\/pnas.96.20.11259","article-title":"The M2-2 protein of human respiratory syncytial virus is a regulatory factor involved in the balance between RNA replication and transcription","volume":"96","author":"Bermingham","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020020313030269700_CIT0026","doi-asserted-by":"crossref","first-page":"e77104","DOI":"10.1371\/journal.pone.0077104","article-title":"Safety and immunogenicity of a live attenuated RSV vaccine in healthy RSV-seronegative children 5 to 24 months of age","volume":"8","author":"Malkin","year":"2013","journal-title":"PLoS One"},{"key":"2020020313030269700_CIT0027","doi-asserted-by":"crossref","first-page":"10792","DOI":"10.1128\/JVI.01227-12","article-title":"Increased genetic and phenotypic stability of a promising live-attenuated respiratory syncytial virus vaccine candidate by reverse genetics","volume":"86","author":"Luongo","year":"2012","journal-title":"J Virol"},{"key":"2020020313030269700_CIT0028","doi-asserted-by":"crossref","first-page":"12128","DOI":"10.1128\/JVI.75.24.12128-12140.2001","article-title":"Granulocyte-macrophage colony-stimulating factor expressed by recombinant respiratory syncytial virus attenuates viral replication and increases the level of pulmonary antigen-presenting cells","volume":"75","author":"Bukreyev","year":"2001","journal-title":"J Virol"},{"key":"2020020313030269700_CIT0029","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/oxfordjournals.aje.a120586","article-title":"An antigenic analysis of respiratory syncytial virus isolates by a plaque reduction neutralization test","volume":"83","author":"Coates","year":"1966","journal-title":"Am J Epidemiol"},{"key":"2020020313030269700_CIT0030","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1086\/514138","article-title":"Evaluation of two live, cold-passaged, temperature-sensitive respiratory syncytial virus vaccines in chimpanzees and in human adults, infants, and children","volume":"176","author":"Karron","year":"1997","journal-title":"J Infect Dis"},{"key":"2020020313030269700_CIT0031","doi-asserted-by":"crossref","first-page":"e50852","DOI":"10.1371\/journal.pone.0050852","article-title":"Respiratory syncytial virus fusion glycoprotein expressed in insect cells form protein nanoparticles that induce protective immunity in cotton rats","volume":"7","author":"Smith","year":"2012","journal-title":"PLoS One"},{"key":"2020020313030269700_CIT0032","doi-asserted-by":"crossref","first-page":"4953","DOI":"10.1016\/j.vaccine.2009.05.099","article-title":"Evaluation of two live attenuated cold-adapted H5N1 influenza virus vaccines in healthy adults","volume":"27","author":"Karron","year":"2009","journal-title":"Vaccine"},{"key":"2020020313030269700_CIT0033","doi-asserted-by":"crossref","first-page":"ofz212","DOI":"10.1093\/ofid\/ofz212","article-title":"Live-Attenuated Respiratory Syncytial Virus Vaccine With Deletion of RNA Synthesis Regulatory Protein M2-2 and Cold Passage Mutations Is Overattenuated","volume":"6","author":"Cunningham","year":"2019","journal-title":"Open Forum Infect Dis"},{"key":"2020020313030269700_CIT0034","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/S0022-3476(81)80829-3","article-title":"Risk of respiratory syncytial virus infection for infants from low-income families in relationship to age, sex, ethnic group, and maternal antibody level","volume":"98","author":"Glezen","year":"1981","journal-title":"J Pediatr"},{"key":"2020020313030269700_CIT0035","first-page":"543","article-title":"Risk of primary infection and reinfection with respiratory syncytial virus","volume":"140","author":"Glezen","year":"1986","journal-title":"Am J Dis Child"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiz603\/31712853\/jiz603.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/221\/4\/534\/32320917\/jiz603.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/221\/4\/534\/32320917\/jiz603.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T13:06:48Z","timestamp":1580735208000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/221\/4\/534\/5638036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,23]]},"references-count":35,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,11,23]]},"published-print":{"date-parts":[[2020,2,3]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiz603","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,2,15]]},"published":{"date-parts":[[2019,11,23]]}}}