{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:38:05Z","timestamp":1784774285902,"version":"3.55.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T00:00:00Z","timestamp":1574985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Sao Paulo Research Foundation"},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Conselho Nacional de Pesquisa e Desenvolvimento Tecnol\u00f3gico"},{"name":"Programa de N\u00facleos de Excel\u00eancia"},{"name":"FAPESP Process","award":["2013\/08216-2"],"award-info":[{"award-number":["2013\/08216-2"]}]},{"name":"Center for Research in Inflammatory Disease","award":["2009\/07651-1"],"award-info":[{"award-number":["2009\/07651-1"]}]},{"name":"Center for Research in Inflammatory Disease","award":["2011\/03293-3"],"award-info":[{"award-number":["2011\/03293-3"]}]},{"DOI":"10.13039\/501100005639","name":"University of Sao Paulo","doi-asserted-by":"publisher","award":["11.1.21625.01"],"award-info":[{"award-number":["11.1.21625.01"]}],"id":[{"id":"10.13039\/501100005639","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Liver X receptors (LXRs) are nuclear receptors activated by oxidized lipids and were previously implicated in several metabolic development and inflammatory disorders. Although neutrophils express both LXR-\u03b1 and LXR-\u03b2, the consequences of their activation, particularly during sepsis, remain unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used the model of cecal ligation and puncture (CLP) to investigate the role of LXR activation during sepsis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In this study, we verified that LXR activation reduces neutrophil chemotactic and killing abilities in vitro. Mice treated with LXR agonists showed higher sepsis-induced mortality, which could be associated with reduced neutrophil infiltration at the infectious foci, increased bacteremia, systemic inflammatory response, and multiorgan failure. In contrast, septic mice treated with LXR antagonist showed increased number of neutrophils in the peritoneal cavity, reduced bacterial load, and multiorgan dysfunction. More important, neutrophils from septic patients showed increased ABCA1 messenger ribonucleic acid levels (a marker of LXR activation) and impaired chemotactic response toward CXCL8 compared with cells from healthy individuals.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Therefore, our findings suggest that LXR activation impairs neutrophil functions, which might contribute to poor sepsis outcome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiz635","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T12:09:49Z","timestamp":1574942989000},"page":"1542-1553","source":"Crossref","is-referenced-by-count":19,"title":["Liver X Receptor Activation Impairs Neutrophil Functions and Aggravates Sepsis"],"prefix":"10.1093","volume":"221","author":[{"given":"Fabr\u00edcio O","family":"Souto","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"},{"name":"Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda V S","family":"Castanheira","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Ribeirao Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"},{"name":"Center of Research of Inflammatory Diseases, Ribeirao Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia C","family":"Trevelin","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Ribeirao Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"},{"name":"King\u2019s College London, British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Braulio H F","family":"Lima","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Ribeirao Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Cesar Martelossi","family":"Cebinelli","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter M","family":"Turato","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Auxiliadora-Martins","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Surgery and Anatomy, Ribeirao Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anibal","family":"Basile-Filho","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Surgery and Anatomy, Ribeirao Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Carlos","family":"Alves-Filho","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Ribeirao Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"},{"name":"Center of Research of Inflammatory Diseases, Ribeirao Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Q","family":"Cunha","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Ribeirao Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"},{"name":"Center of Research of Inflammatory Diseases, Ribeirao Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,11,29]]},"reference":[{"key":"2020040710053340900_CIT0001","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"2020040710053340900_CIT0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-15755-1","article-title":"Proteomic study revealed cellular 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