{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:03:57Z","timestamp":1792843437886,"version":"4.5.0"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["T32 AI118690-02"],"award-info":[{"award-number":["T32 AI118690-02"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["HHSN272201600016C"],"award-info":[{"award-number":["HHSN272201600016C"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["HHSN272201100041C"],"award-info":[{"award-number":["HHSN272201100041C"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["HHSN272201600019C"],"award-info":[{"award-number":["HHSN272201600019C"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cytomegalovirus (CMV) reactivation has been described in adults with critical illness caused by diverse etiologies, especially severe sepsis, and observational studies have linked CMV reactivation with worse clinical outcomes in this setting. In this study, we review observational clinical data linking development of CMV reactivation with worse outcomes in patients in the intensive care unit, discuss potential biologically plausible mechanisms for a causal association, and summarize results of initial interventional trials that examined the effects of CMV prevention. These data, taken together, highlight the need for a randomized, placebo-controlled efficacy trial (1) to definitively determine whether prevention of CMV reactivation improves clinical outcomes of patients with critical illness and (2) to define the underlying mechanism(s).<\/jats:p>","DOI":"10.1093\/infdis\/jiz638","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T15:10:25Z","timestamp":1575990625000},"page":"S94-S102","source":"Crossref","is-referenced-by-count":65,"title":["Current Understanding of Cytomegalovirus Reactivation in Critical Illness"],"prefix":"10.1093","volume":"221","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3429-4655","authenticated-orcid":false,"given":"Hannah","family":"Imlay","sequence":"first","affiliation":[{"name":"Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit P","family":"Limaye","sequence":"first","affiliation":[{"name":"Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,5]]},"reference":[{"key":"2020030507501100600_CIT0001","article-title":"National Inpatient Hospital Costs: The Most Expensive Conditions by Payer, 2013: Statistical Brief #204. 2016 May","author":"Torio"},{"key":"2020030507501100600_CIT0002","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJM200005043421801","article-title":"Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome","volume":"342","author":"Brower","year":"2000","journal-title":"New Eng J Med"},{"key":"2020030507501100600_CIT0003","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1056\/NEJMoa062200","article-title":"Comparison of two fluid-management strategies in acute lung injury","volume":"354","author":"Wiedemann","year":"2006","journal-title":"New Eng J Med"},{"key":"2020030507501100600_CIT0004","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1001\/jama.2008.697","article-title":"Cytomegalovirus reactivation in critically ill immunocompetent patients","volume":"300","author":"Limaye","year":"2008","journal-title":"JAMA"},{"key":"2020030507501100600_CIT0005","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1097\/CCM.0b013e3181a3aa43","article-title":"Prevalence and mortality associated with cytomegalovirus infection in nonimmunosuppressed patients in the intensive care unit","volume":"37","author":"Kalil","year":"2009","journal-title":"Crit Care Med"},{"key":"2020030507501100600_CIT0006","doi-asserted-by":"crossref","first-page":"ofx029","DOI":"10.1093\/ofid\/ofx029","article-title":"Association between cytomegalovirus reactivation and clinical outcomes in immunocompetent critically ill patients: a systematic review and meta-analysis","volume":"4","author":"Lachance","year":"2017","journal-title":"Open Forum Infect Dis"},{"key":"2020030507501100600_CIT0007","doi-asserted-by":"crossref","first-page":"R68","DOI":"10.1186\/cc7875","article-title":"Cytomegalovirus infection in critically ill patients: a systematic review","volume":"13","author":"Osawa","year":"2009","journal-title":"Crit Care"},{"key":"2020030507501100600_CIT0008","doi-asserted-by":"crossref","first-page":"e98819","DOI":"10.1371\/journal.pone.0098819","article-title":"Reactivation of multiple viruses in patients with sepsis","volume":"9","author":"Walton","year":"2014","journal-title":"PLoS One"},{"key":"2020030507501100600_CIT0009","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1093\/cid\/cix120","article-title":"Epidemiology of multiple herpes viremia in previously immunocompetent patients with septic shock","volume":"64","author":"Ong","year":"2017","journal-title":"Clin Infect Dis"},{"key":"2020030507501100600_CIT0010","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1097\/CCM.0000000000000969","article-title":"Coreactivation of human herpesvirus 6 and cytomegalovirus is associated with worse clinical outcome in critically ill adults","volume":"43","author":"Lopez Roa","year":"2015","journal-title":"Crit Care Med"},{"key":"2020030507501100600_CIT0011","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nri3552","article-title":"Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy","volume":"13","author":"Hotchkiss","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"2020030507501100600_CIT0012","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/imr.12499","article-title":"The immune system\u2019s role in sepsis progression, resolution, and long-term outcome","volume":"274","author":"Delano","year":"2016","journal-title":"Immunol Rev"},{"key":"2020030507501100600_CIT0013","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1615\/CritRevImmunol.2016017098","article-title":"Clinical and experimental sepsis impairs CD8 T-cell-mediated immunity","volume":"36","author":"Danahy","year":"2016","journal-title":"Crit Rev Immunol"},{"key":"2020030507501100600_CIT0014","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/2052-0492-2-32","article-title":"Pathophysiology and biomarkers of acute respiratory distress syndrome","volume":"2","author":"Fujishima","year":"2014","journal-title":"J Intensive Care"},{"key":"2020030507501100600_CIT0015","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1056\/NEJMra1608077","article-title":"Acute respiratory distress syndrome","volume":"377","author":"Thompson","year":"2017","journal-title":"N Engl J Med"},{"key":"2020030507501100600_CIT0016","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s00134-015-4066-9","article-title":"Cytomegalovirus reactivation in ICU patients","volume":"42","author":"Papazian","year":"2016","journal-title":"Intensive Care Med"},{"key":"2020030507501100600_CIT0017","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1001\/jama.2017.10569","article-title":"Effect of ganciclovir on IL-6 levels among cytomegalovirus-seropositive adults with critical illness: a randomized clinical trial","volume":"318","author":"Limaye","year":"2017","journal-title":"JAMA"},{"key":"2020030507501100600_CIT0018","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"2020030507501100600_CIT0018a","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1182\/blood.V86.9.3598.bloodjournal8693598","article-title":"A comparison of filtered leukocyte-reduced and cytomegalovirus (CMV) seronegative blood products for the prevention of transfusion-associated CMV infection after marrow transplant","volume":"86","author":"Bowden","year":"1995","journal-title":"Blood"},{"key":"2020030507501100600_CIT0019","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1093\/clinids\/23.2.292","article-title":"Primary cytomegalovirus infection in liver transplant recipients: comparison of infections transmitted via donor organs and via transfusions. Boston Center for Liver Transplantation CMVIG Study Group","volume":"23","author":"Falagas","year":"1996","journal-title":"Clin Infect Dis"},{"key":"2020030507501100600_CIT0020","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/s12879-018-3195-5","article-title":"Cytomegalovirus infection and outcome in immunocompetent patients in the intensive care unit: a systematic review and meta-analysis","volume":"18","author":"Li","year":"2018","journal-title":"BMC Infect Dis"},{"key":"2020030507501100600_CIT0021","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1097\/01.CCM.0000070222.11325.C4","article-title":"Occult herpes family viral infections are endemic in critically ill surgical patients","volume":"31","author":"Cook","year":"2003","journal-title":"Crit Care Med"},{"key":"2020030507501100600_CIT0022","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1097\/CCM.0b013e31819ffea6","article-title":"Active cytomegalovirus infection is common in mechanically ventilated medical intensive care unit patients","volume":"37","author":"Chiche","year":"2009","journal-title":"Crit Care Med"},{"key":"2020030507501100600_CIT0023","doi-asserted-by":"crossref","first-page":"R77","DOI":"10.1186\/cc10069","article-title":"Cytomegalovirus reactivation and associated outcome of critically ill patients with severe sepsis","volume":"15","author":"Heininger","year":"2011","journal-title":"Crit Care"},{"key":"2020030507501100600_CIT0024","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00134-015-4071-z","article-title":"Cytomegalovirus reactivation and mortality in patients with acute respiratory distress syndrome","volume":"42","author":"Ong","year":"2016","journal-title":"Intensive Care Med"},{"key":"2020030507501100600_CIT0025","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1093\/cid\/civ561","article-title":"Strong cell-mediated immune response to human cytomegalovirus is associated with increased risk of fetal infection in primarily infected pregnant women","volume":"61","author":"Saldan","year":"2015","journal-title":"Clin Infect Dis"},{"key":"2020030507501100600_CIT0026","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.antiviral.2009.12.004","article-title":"Antiviral prevention of sepsis induced cytomegalovirus reactivation in immunocompetent mice","volume":"85","author":"Forster","year":"2010","journal-title":"Antiviral Res"},{"key":"2020030507501100600_CIT0027","doi-asserted-by":"crossref","first-page":"ciz490","DOI":"10.1093\/cid\/ciz490","article-title":"A mortality analysis of letermovir prophylaxis for cytomegalovirus (CMV) in CMV-seropositive recipients of allogeneic hematopoietic-cell transplantation","volume":"pii","author":"Ljungman","year":"2019","journal-title":"Clin Infect Dis"},{"key":"2020030507501100600_CIT0028","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1002\/jmv.22202","article-title":"Immunological insights into the pathogenesis of active CMV infection in non-immunosuppressed critically ill patients","volume":"83","author":"Blanquer","year":"2011","journal-title":"J Med Virol"},{"key":"2020030507501100600_CIT0029","doi-asserted-by":"crossref","first-page":"5360","DOI":"10.1128\/JVI.67.9.5360-5366.1993","article-title":"Lungs are a major organ site of cytomegalovirus latency and recurrence","volume":"67","author":"Balthesen","year":"1993","journal-title":"J Virol"},{"key":"2020030507501100600_CIT0030","first-page":"638","article-title":"Cytomegalovirus infection and survival in lung transplant recipients","volume":"10","author":"Duncan","year":"1991","journal-title":"J Heart Lung Transplant"},{"key":"2020030507501100600_CIT0031","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1164\/ajrccm\/147.4.1017","article-title":"Cytomegalovirus infection and pneumonitis. Impact after isolated lung transplantation. Washington University Lung Transplant Group","volume":"147","author":"Ettinger","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"2020030507501100600_CIT0032","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1177\/0885066613476454","article-title":"Cytomegalovirus pneumonia in hematopoietic stem cell recipients","volume":"29","author":"Travi","year":"2014","journal-title":"J Intensive Care Med"},{"key":"2020030507501100600_CIT0033","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1097\/01.CCM.0000257325.88144.30","article-title":"A contributive result of open-lung biopsy improves survival in acute respiratory distress syndrome patients","volume":"35","author":"Papazian","year":"2007","journal-title":"Crit Care Med"},{"key":"2020030507501100600_CIT0034","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1097\/00000542-199804000-00013","article-title":"Open-lung biopsy in patients with acute respiratory distress syndrome","volume":"88","author":"Papazian","year":"1998","journal-title":"Anesthesiology"},{"key":"2020030507501100600_CIT0035","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/00000542-199602000-00005","article-title":"Cytomegalovirus. an unexpected cause of ventilator-associated pneumonia","volume":"84","author":"Papazian","year":"1996","journal-title":"Anesthesiology"},{"key":"2020030507501100600_CIT0036","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.4049\/jimmunol.1303441","article-title":"Altered microRNA expression after infection with human cytomegalovirus leads to TIMP3 downregulation and increased shedding of metalloprotease substrates, including MICA","volume":"193","author":"Esteso","year":"2014","journal-title":"J Immunol"},{"key":"2020030507501100600_CIT0037","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.pmbts.2017.04.004","article-title":"The role of matrix metalloproteinases in development, repair, and destruction of the lungs","volume":"148","author":"Hendrix","year":"2017","journal-title":"Prog Mol Biol Transl Sci"},{"key":"2020030507501100600_CIT0038","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2174\/138620712801619159","article-title":"Targeting matrix metalloproteinases in acute inflammatory shock syndromes","volume":"15","author":"Qiu","year":"2012","journal-title":"Comb Chem High Throughput Screen"},{"key":"2020030507501100600_CIT0039","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1128\/JVI.01363-08","article-title":"Infection with human cytomegalovirus alters the MMP-9\/TIMP-1 balance in human macrophages","volume":"83","author":"Str\u00e5\u00e5t","year":"2009","journal-title":"J Virol"},{"key":"2020030507501100600_CIT0040","first-page":"58","article-title":"Induction of endothelial adhesion molecules by rat cytomegalovirus in allogeneic lung transplantation in the rat","volume":"99","author":"Steinhoff","year":"1995","journal-title":"Scand J Infect Dis Suppl"},{"key":"2020030507501100600_CIT0041","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1549-8719.2011.00106.x","article-title":"P-selectin mediates the microvascular dysfunction associated with persistent cytomegalovirus infection in normocholesterolemic and hypercholesterolemic mice","volume":"18","author":"Senchenkov","year":"2011","journal-title":"Microcirculation"},{"key":"2020030507501100600_CIT0042","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1097\/01.CCM.0000201876.11059.05","article-title":"Pulmonary cytomegalovirus reactivation causes pathology in immunocompetent mice","volume":"34","author":"Cook","year":"2006","journal-title":"Crit Care Med"},{"key":"2020030507501100600_CIT0043","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2014.12.020","article-title":"Variation in the human immune system is largely driven by non-heritable influences","volume":"160","author":"Brodin","year":"2015","journal-title":"Cell"},{"key":"2020030507501100600_CIT0044","first-page":"12","article-title":"Immunosuppressive effects of beta-herpesviruses","volume":"10","author":"Boeckh","year":"2003","journal-title":"Herpes"},{"key":"2020030507501100600_CIT0045","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1086\/314734","article-title":"Cytomegalovirus induction of interleukin-6 in lung fibroblasts occurs independently of active infection and involves a G protein and the transcription factor, NF-kappaB","volume":"179","author":"Carlquist","year":"1999","journal-title":"J Infect Dis"},{"key":"2020030507501100600_CIT0046","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1128\/JVI.77.8.4588-4596.2003","article-title":"Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2","volume":"77","author":"Compton","year":"2003","journal-title":"J Virol"},{"key":"2020030507501100600_CIT0047","doi-asserted-by":"crossref","first-page":"5692","DOI":"10.1128\/JVI.71.7.5692-5695.1997","article-title":"Human cytomegalovirus induces interleukin-8 production by a human monocytic cell line, THP-1, through acting concurrently on AP-1- and NF-kappaB-binding sites of the interleukin-8 gene","volume":"71","author":"Murayama","year":"1997","journal-title":"J Virol"},{"key":"2020030507501100600_CIT0048","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1046\/j.1365-2567.1997.00310.x","article-title":"Human cytomegalovirus infection up-regulates interleukin-8 gene expression and stimulates neutrophil transendothelial migration","volume":"92","author":"Craigen","year":"1997","journal-title":"Immunology"},{"key":"2020030507501100600_CIT0049","first-page":"175","article-title":"Cytomegalovirus immediate early genes upregulate interleukin-6 gene expression","volume":"45","author":"Iwamoto","year":"1997","journal-title":"J Investig Med"},{"key":"2020030507501100600_CIT0050","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/jmv.1013","article-title":"Association of tumour necrosis factor alpha and interleukin 6 levels with cytomegalovirus DNA detection and disease after renal transplantation","volume":"64","author":"Tong","year":"2001","journal-title":"J Med Virol"},{"key":"2020030507501100600_CIT0051","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1086\/314602","article-title":"Elevated serum cytokines are associated with cytomegalovirus infection and disease in bone marrow transplant recipients","volume":"179","author":"Humar","year":"1999","journal-title":"J Infect Dis"},{"key":"2020030507501100600_CIT0052","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/00007890-199309000-00024","article-title":"In situ production of interleukin-6 within human lung allografts displaying rejection or cytomegalovirus pneumonia","volume":"56","author":"Humbert","year":"1993","journal-title":"Transplantation"},{"key":"2020030507501100600_CIT0053","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1164\/ajrccm\/145.5.1178","article-title":"Activation of macrophages and cytotoxic cells during cytomegalovirus pneumonia complicating lung transplantations","volume":"145","author":"Humbert","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"2020030507501100600_CIT0054","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.CCM.0000149854.61192.DC","article-title":"Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury","volume":"33","author":"Parsons","year":"2005","journal-title":"Crit Care Med"},{"key":"2020030507501100600_CIT0055","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1001\/jamainternmed.2017.0895","article-title":"Safety and efficacy of antiviral therapy for prevention of cytomegalovirus reactivation in immunocompetent critically ill patients: a randomized clinical trial","volume":"177","author":"Cowley","year":"2017","journal-title":"JAMA Intern Med"},{"key":"2020030507501100600_CIT0056","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1186\/s13054-018-2261-0","article-title":"Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study","volume":"22","author":"van de Groep","year":"2018","journal-title":"Crit Care"},{"key":"2020030507501100600_CIT0057","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.3389\/fmicb.2016.02111","article-title":"Mechanisms underlying T cell immunosenescence: aging and cytomegalovirus infection","volume":"7","author":"Tu","year":"2016","journal-title":"Front Microbiol"},{"key":"2020030507501100600_CIT0058","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1172\/JCI45449","article-title":"Cytomegalovirus: pathogen, paradigm, and puzzle","volume":"121","author":"Boeckh","year":"2011","journal-title":"J Clin Invest"},{"key":"2020030507501100600_CIT0059","doi-asserted-by":"crossref","first-page":"7759","DOI":"10.1128\/JVI.01262-06","article-title":"The cytomegalovirus-specific CD4+ T-cell response expands with age and markedly alters the CD4+ T-cell repertoire","volume":"81","author":"Pourgheysari","year":"2007","journal-title":"J Virol"},{"key":"2020030507501100600_CIT0060","doi-asserted-by":"crossref","first-page":"173","DOI":"10.7326\/0003-4819-118-3-199302010-00003","article-title":"Ganciclovir prophylaxis to prevent cytomegalovirus disease after allogeneic marrow transplant","volume":"118","author":"Goodrich","year":"1993","journal-title":"Ann Intern Med"},{"key":"2020030507501100600_CIT0061","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1182\/blood.V90.6.2502","article-title":"Neutropenia in allogeneic marrow transplant recipients receiving ganciclovir for prevention of cytomegalovirus disease: risk factors and outcome","volume":"90","author":"Salzberger","year":"1997","journal-title":"Blood"},{"key":"2020030507501100600_CIT0062","doi-asserted-by":"crossref","first-page":"984","DOI":"10.7326\/0003-4819-119-10-199311150-00004","article-title":"Cytomegalovirus immune globulin prophylaxis in liver transplantation. A randomized, double-blind, placebo-controlled trial","volume":"119","author":"Snydman","year":"1993","journal-title":"Ann Intern Med"},{"key":"2020030507501100600_CIT0063","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1056\/NEJM199905133401903","article-title":"Valacyclovir for the prevention of cytomegalovirus disease after renal transplantation. International Valacyclovir Cytomegalovirus Prophylaxis Transplantation Study Group","volume":"340","author":"Lowance","year":"1999","journal-title":"N Engl J Med"},{"key":"2020030507501100600_CIT0064","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1056\/NEJM198710223171703","article-title":"Use of cytomegalovirus immune globulin to prevent cytomegalovirus disease in renal-transplant recipients","volume":"317","author":"Snydman","year":"1987","journal-title":"N Engl J Med"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/221\/Supplement_1\/S94\/32791399\/jiz638.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/221\/Supplement_1\/S94\/32791399\/jiz638.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T07:51:02Z","timestamp":1583394662000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/221\/Supplement_1\/S94\/5781914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,5]]},"references-count":65,"journal-issue":{"issue":"Supplement_1","published-online":{"date-parts":[[2020,3,5]]},"published-print":{"date-parts":[[2020,3,5]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiz638","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,3,15]]},"published":{"date-parts":[[2020,3,5]]}}}