{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:29:48Z","timestamp":1782487788347,"version":"3.54.5"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2019,12,14]],"date-time":"2019-12-14T00:00:00Z","timestamp":1576281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Leading Advanced Projects for medical innovation","award":["JP19am001007"],"award-info":[{"award-number":["JP19am001007"]}]},{"name":"Japan Initiative for Global Research Network on Infectious Diseases","award":["JP19fm0108006"],"award-info":[{"award-number":["JP19fm0108006"]}]},{"name":"Research Program on Emerging and Re-emerging Infectious 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from the respiratory tract, leading to the emergence of drug-resistant mutant viruses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this study, we examined the efficacy of baloxavir marboxil in nude mice that were immunologically deficient.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Daily treatment with a suboptimal dose of baloxavir marboxil increased the survival time of the virus-infected nude mice but did not clear the virus from their respiratory organs, resulting in gradual body weight loss after termination of treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Despite the prolonged baloxavir marboxil treatment, few resistant mutants were detected.<\/jats:p>\n          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