{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:34:59Z","timestamp":1761514499801,"version":"3.37.3"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T00:00:00Z","timestamp":1576454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The Chlamydia trachomatis bacterial load could have impact on transmission and sequelae. This is the first study providing comparison of C. trachomatis load at 3 anatomic sites estimated by cycle quantification (Cq) values.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data from 7900 C. trachomatis-positive samples were included (2012\u20132018). Cq value was used as an inversely proportional measure for C. trachomatis load. Multivariable linear regression analyses assessed differences in mean Cq values.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Vaginal swabs had the lowest Cq values (31.0) followed by urine (32.5), anorectal swabs (34.0), and oropharyngeal swabs (36.8) (P &amp;lt; .001). Men and women had similar oropharyngeal (36.4 vs 37.3; P = .13) and anorectal (34.2 vs 33.9; P = .19) Cq values. Men (32.2) and women (30.7) aged &amp;lt;25 years had lower urogenital Cq values than men (32.8) and women (31.9) aged \u226525 years (P &amp;lt; .001). HIV-positive patients had higher urogenital Cq values than HIV-negative patients (33.8 vs 32.6; P &amp;lt; .03).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Men and women have a similar C. trachomatis load at extragenital locations arguing for similar transmission potential and clinical relevance. Older patients and HIV-coinfected patients had lower C. trachomatis load, suggesting exposure to previous C. trachomatis infections potentially leading to partial immunity reducing load.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiz668","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T12:10:43Z","timestamp":1576239043000},"page":"1582-1589","source":"Crossref","is-referenced-by-count":11,"title":["Men and Women Have an Equal Oropharyngeal and Anorectal <i>Chlamydia trachomatis<\/i> Bacterial Load: A Comparison of 3 Anatomic Sites"],"prefix":"10.1093","volume":"223","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3772-6414","authenticated-orcid":false,"given":"Juli\u00ebn N A P","family":"Wijers","sequence":"first","affiliation":[{"name":"Department of Social Medicine and Medical Microbiology, Care and Public Health Research Institute Maastricht University Medical Center, Maastricht, the Netherlands"},{"name":"Department of 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