{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:13:24Z","timestamp":1759529604160,"version":"3.37.3"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T00:00:00Z","timestamp":1578009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI114953"],"award-info":[{"award-number":["R21AI114953"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The T-cell response to chlamydia genital tract infections in humans and mice is unusual because the majority of antigen-specific CD8 T cells are not class I restricted (referred to here as \u201cunrestricted\u201d or \u201catypical\u201d). We previously reported that a subset of unrestricted murine chlamydia-specific CD8 T cells had a cytokine polarization pattern that included interferon (IFN)-\u03b3 and interleukin (IL)-13.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we investigated the transcriptome of CD8\u03b313 T cells, comparing them to Tc1 clones using microarray analysis. That study revealed that CD8\u03b313 polarization included IL-5 in addition to IFN-\u03b3 and IL-13. Adoptive transfer studies were performed with Tc1 clones and a CD8\u03b313 T-cell clone to determine whether either influenced bacterial clearance or immunopathology during Chlamydia muridarum genital tract infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>To our surprise, an adoptively transferred CD8\u03b313 T-cell clone was remarkably proficient at preventing chlamydia immunopathology, whereas the multifunctional Tc1 clone did not enhance clearance or significantly alter immunopathology. Mapping studies with major histocompatibility complex (MHC) class I- and class II-deficient splenocytes showed our previously published chlamydia-specific CD8 T-cell clones are MHC class II restricted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The MHC class II-restricted CD8 T cells may play an important role in protection from intracellular pathogens that limit class I antigen presentation or diminish CD4 T-cell numbers or impair their function.<\/jats:p><\/jats:sec>","DOI":"10.1093\/infdis\/jiz685","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T20:09:23Z","timestamp":1577822963000},"page":"1895-1906","source":"Crossref","is-referenced-by-count":8,"title":["A Class II-Restricted CD8\u03b313 T-Cell Clone Protects During Chlamydia muridarum Genital Tract Infection"],"prefix":"10.1093","volume":"221","author":[{"given":"Raymond M","family":"Johnson","sequence":"first","affiliation":[{"name":"Section of Infectious Diseases, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma","family":"Olivares-Strank","sequence":"first","affiliation":[{"name":"Section of Infectious Diseases, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0307-9351","authenticated-orcid":false,"given":"Gang","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Biostatistics, Yale University School of Medicine, New Haven, Connecticut, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,1,3]]},"reference":[{"volume-title":"Sexually transmitted disease surveillance 2015","year":"2016","author":"Centers for Disease Control and 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