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As the effects of the microenvironment on cancer cell behavior becomes more understood, researchers have called for the integration of the microenvironment into in vitro chemical testing systems. However, given the complexity of the microenvironment and the variety of platforms to choose from, identifying the essential parameters to include in a chemical testing platform is challenging. This review discusses the need for more complex in vitro breast cancer models and outlines different approaches used to model breast cancer in vitro. We provide examples of the microenvironment modulating breast cancer cell responses to chemicals and discuss strategies to help pinpoint what components should be included in a model.<\/jats:p>","DOI":"10.1093\/intbio\/zyaa002","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T09:33:14Z","timestamp":1583141594000},"page":"21-33","source":"Crossref","is-referenced-by-count":13,"title":["Modeling chemical effects on breast cancer: the importance of the microenvironment in vitro"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5556-7803","authenticated-orcid":false,"given":"Molly M","family":"Morgan","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda A","family":"Schuler","sequence":"first","affiliation":[{"name":"Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, USA"},{"name":"Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan C","family":"Ciciliano","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian P","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine T","family":"Alarid","sequence":"first","affiliation":[{"name":"Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, WI, USA"},{"name":"Department of Oncology, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David 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