{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:13:00Z","timestamp":1790251980497,"version":"4.1.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Recent findings in cancer research have pointed towards the bidirectional interaction between circadian and hypoxia pathways. However, little is known about their crosstalk mechanism. In this work, we aimed to investigate this crosstalk at a network level utilizing the omics information of gallbladder cancer. Differential gene expression and pathway enrichment analysis were used for selecting the crucial genes from both the pathways, followed by the construction of a logical crosstalk model using GINsim. Functional circuit identification and node perturbations were then performed. Significant node combinations were used to investigate the temporal behavior of the network through MaBoSS. Lastly, the model was validated using published in vitro experimentations. Four new positive circuits and a new axis viz. BMAL1\/ HIF1\u03b1\u03b2\/ NANOG, responsible for stemness were identified. Through triple node perturbations viz.a. BMAL:CLOCK (KO or E1)\u2009+\u2009P53 (E1)\u2009+\u2009HIF1\u03b1 (KO); b. P53 (E1)\u2009+\u2009HIF1\u03b1 (KO)\u2009+\u2009MYC (E1); and c. HIF1\u03b1 (KO)\u2009+\u2009MYC (E1)\u2009+\u2009EGFR (KO), the model was able to inhibit cancer growth and maintain a homeostatic condition. This work provides an architecture for drug simulation analysis to entrainment circadian rhythm and in vitro experiments for chronotherapy-related studies.<\/jats:p>\n               <jats:p>Insight Box. Circadian rhythm and hypoxia are the key dysregulated processes which fuels-up the cancer growth. In the present work we have developed a gallbladder cancer (GBC) specific Boolean model, utilizing the RNASeq data from GBC dataset and tissue specific interactions. This work adequately models the bidirectional nature of interactions previously illustrated in experimental papers showing the effect of hypoxia on dysregulation of circadian rhythm and the influence of this disruption on progression towards metastasis. Through the dynamical study of the model and its response to different perturbations, we report novel triple node combinations that can be targeted to efficiently reduce GBC growth. This network can be used as a generalized framework to investigate different crosstalk pathways linked with cancer progression.<\/jats:p>","DOI":"10.1093\/intbio\/zyae018","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:23:03Z","timestamp":1730812983000},"source":"Crossref","is-referenced-by-count":1,"title":["Network dynamics investigation of omics-data-driven circadian-hypoxia crosstalk logical model in gallbladder cancer reveals key therapeutic target combinations"],"prefix":"10.1093","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8607-2723","authenticated-orcid":false,"given":"Aakansha","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Bioengineering and Biotechnology, Birla Institute of Technology , Mesra, Ranchi 835215, Jharkhand ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5356-9941","authenticated-orcid":false,"given":"Anjana","family":"Dwivedi","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Biotechnology, Birla Institute of Technology , Mesra, Ranchi 835215, Jharkhand ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"2024110513581773300_ref1","doi-asserted-by":"crossref","first-page":"111674","DOI":"10.1016\/j.mrfmmm.2019.111674","article-title":"Molecular pathogenesis of gallbladder cancer: An update","volume":"816-818","author":"Mishra","year":"2019","journal-title":"Mutat Res Fundam Mol Mech Mutagen"},{"key":"2024110513581773300_ref2","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1158\/0008-5472.CAN-19-0566","article-title":"Cancer and the circadian clock","volume":"79","author":"Shafi","year":"2019","journal-title":"Cancer Res"},{"key":"2024110513581773300_ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12943-019-1089-9","article-title":"Role of hypoxia in cancer therapy by regulating the tumor microenvironment","volume":"18","author":"Jing","year":"2019","journal-title":"Mol Cancer"},{"key":"2024110513581773300_ref4","first-page":"379","volume-title":"Seminars in Cancer Biology","author":"Ma","year":"2022"},{"key":"2024110513581773300_ref5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41392-022-00899-y","article-title":"Molecular regulations of circadian rhythm and implications for physiology and diseases","volume":"7","author":"Fagiani","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"2024110513581773300_ref6","doi-asserted-by":"crossref","first-page":"100787","DOI":"10.1016\/j.drup.2021.100787","article-title":"Hypoxia as a driver of resistance to immunotherapy","volume":"59","author":"Kopecka","year":"2021","journal-title":"Drug Resist Updat"},{"key":"2024110513581773300_ref7","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.3390\/ijms23031331","article-title":"Chronoradiobiology of breast cancer: The time is now to link circadian rhythm and radiation biology","volume":"23","author":"Nelson","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2024110513581773300_ref8","doi-asserted-by":"crossref","first-page":"18790","DOI":"10.1073\/pnas.1115249108","article-title":"Control of skin cancer by the circadian rhythm","volume":"108","author":"Gaddameedhi","year":"2011","journal-title":"Proc Natl Acad Sci"},{"key":"2024110513581773300_ref9","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.trecan.2023.11.002","article-title":"Learning from circadian rhythm to transform cancer prevention, prognosis, and survivorship care","volume":"10","author":"Zhu","year":"2023","journal-title":"Trends Cancer"},{"key":"2024110513581773300_ref10","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s10549-022-06792-0","article-title":"Circadian rhythm disrupting behaviours and cancer outcomes in breast cancer survivors: A systematic review","volume":"198","author":"D\u2019cunha","year":"2023","journal-title":"Breast Cancer Res Treat"},{"key":"2024110513581773300_ref11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41580-019-0179-2","article-title":"Molecular mechanisms and physiological importance of circadian rhythms","volume":"21","author":"Patke","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2024110513581773300_ref12","first-page":"C533","article-title":"Out of breath, out of time: Interactions between HIF and circadian rhythms. American journal of physiology-cell","volume":"319","author":"O\u2019Connell","year":"2020","journal-title":"Phys Ther"},{"key":"2024110513581773300_ref13","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3390\/clockssleep1040034","article-title":"The cancer clock is (not) ticking: Links between circadian rhythms and cancer","volume":"1","author":"Morgan","year":"2019","journal-title":"Clocks & Sleep"},{"key":"2024110513581773300_ref14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13098-015-0041-4","article-title":"Shift work and its association with metabolic disorders","volume":"7","author":"Brum","year":"2015","journal-title":"Diabetol Metab Syndr"},{"key":"2024110513581773300_ref15","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41569-019-0167-4","article-title":"Circadian rhythms and the molecular clock in cardiovascular biology and disease","volume":"16","author":"Crnko","year":"2019","journal-title":"Nat Rev Cardiol"},{"key":"2024110513581773300_ref16","doi-asserted-by":"crossref","first-page":"6140","DOI":"10.3390\/ijms20246140","article-title":"Hypoxia: Overview on hypoxia-mediated mechanisms with a focus on the role of HIF genes","volume":"20","author":"Tirpe","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2024110513581773300_ref17","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fcell.2019.00004","article-title":"Hypoxia-modified cancer cell metabolism","volume":"7","author":"Al Tameemi","year":"2019","journal-title":"Front Cell Dev Biol"},{"key":"2024110513581773300_ref18","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/nrc3621","article-title":"bHLH\u2013PAS proteins in cancer","volume":"13","author":"Bersten","year":"2013","journal-title":"Nat Rev Cancer"},{"key":"2024110513581773300_ref19","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1073\/pnas.1914112117","article-title":"Hypoxia induces a time-and tissue-specific response that elicits intertissue circadian clock misalignment","volume":"117","author":"Manella","year":"2020","journal-title":"Proc Natl Acad Sci"},{"key":"2024110513581773300_ref20","first-page":"26","article-title":"Chinese body clock: in-depth review-based perspective","volume":"6","author":"Bharti","year":"2021","journal-title":"Int J Res Dev"},{"key":"2024110513581773300_ref21","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.csbj.2020.03.001","article-title":"Concepts in Boolean network modeling: What do they all mean?","volume":"18","author":"Schwab","year":"2020","journal-title":"Comput Struct Biotechnol J"},{"key":"2024110513581773300_ref22","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/bioinformatics\/btr697","article-title":"Modeling mechanistic biological networks: An advanced Boolean approach","volume":"28","author":"Handorf","year":"2012","journal-title":"Bioinformatics"},{"key":"2024110513581773300_ref23","doi-asserted-by":"crossref","first-page":"055001","DOI":"10.1088\/1478-3975\/9\/5\/055001","article-title":"Boolean modeling in systems biology: An overview of methodology and applications","volume":"9","author":"Wang","year":"2012","journal-title":"Phys Biol"},{"key":"2024110513581773300_ref24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1751-0473-3-16","article-title":"Boolean network simulations for life scientists","volume":"3","author":"Albert","year":"2008","journal-title":"Source Code Biol Med"},{"key":"2024110513581773300_ref25","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/1873-3468.13615","article-title":"ATM\/miR-34a-5p axis regulates a p21-dependent senescence-apoptosis switch in non-small cell lung cancer: A Boolean model of G1\/S checkpoint regulation","volume":"594","author":"Gupta","year":"2020","journal-title":"FEBS Lett"},{"key":"2024110513581773300_ref26","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.compbiomed.2018.11.025","article-title":"Towards the contribution of the p38MAPK pathway to the dual role of TGF\u03b2 in cancer: A boolean model approach","volume":"104","author":"Rossato","year":"2019","journal-title":"Comput Biol Med"},{"key":"2024110513581773300_ref27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.semcdb.2021.07.017","article-title":"Circadian clock synchrony and chronotherapy opportunities in cancer treatment","volume":"126","author":"Damato","year":"2022","journal-title":"Semin Cell Dev Biol"},{"key":"2024110513581773300_ref28","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.3390\/cancers14205071","article-title":"Chronotherapy: Circadian rhythms and their influence in cancer therapy","volume":"14","author":"Amiama-Roig","year":"2022","journal-title":"Cancer"},{"key":"2024110513581773300_ref29","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s11060-019-03332-7","article-title":"Radiation chronotherapy\u2014Clinical impact of treatment time-of-day: A systematic review","volume":"145","author":"Shuboni-Mulligan","year":"2019","journal-title":"J Neurooncol"},{"key":"2024110513581773300_ref30","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.1038\/s41467-019-13420-x","article-title":"Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer","volume":"10","author":"Xu","year":"2019","journal-title":"Nat Commun"},{"key":"2024110513581773300_ref31","doi-asserted-by":"crossref","first-page":"e0283770","DOI":"10.1371\/journal.pone.0283770","article-title":"RNA sequencing revealed the multi-stage transcriptome transformations during the development of gallbladder cancer associated with chronic inflammation","volume":"18","author":"Yang","year":"2023","journal-title":"PloS One"},{"key":"2024110513581773300_ref32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12859-018-2486-6","article-title":"iDEP: An integrated web application for differential expression and pathway analysis of RNA-Seq data","volume":"19","author":"Ge","year":"2018","journal-title":"BMC bioinf"},{"key":"2024110513581773300_ref33","first-page":"10","article-title":"Differential analysis of count data\u2013the DESeq2 package","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2024110513581773300_ref34","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1016\/j.csbj.2022.06.035","article-title":"Boolean modelling as a logic-based dynamic approach in systems medicine","volume":"20","author":"Hemedan","year":"2022","journal-title":"Comput Struct Biotechnol J"},{"key":"2024110513581773300_ref35","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1089\/nsm.2020.0002","article-title":"Mechanistic modeling and multiscale applications for precision medicine: Theory and practice","volume":"3","author":"Stalidzans","year":"2020","journal-title":"Network and systems medicine"},{"key":"2024110513581773300_ref36","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/wsbm.1273","article-title":"Boolean modeling: A logic-based dynamic approach for understanding signaling and regulatory networks and for making useful predictions","volume":"6","author":"Albert","year":"2014","journal-title":"Wiley Interdiscip Rev Syst Biol Med"},{"key":"2024110513581773300_ref37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/1-4020-4223-X_5","volume-title":"Formal Methods for Modeling Biological Regulatory Networks. In Modern Formal Methods and Applications","author":"Richard","year":"2006"},{"key":"2024110513581773300_ref38","doi-asserted-by":"crossref","first-page":"787","DOI":"10.3389\/fphys.2018.00787","article-title":"Prediction of mutations to control pathways enabling tumor cell invasion with the CoLoMoTo interactive notebook (tutorial)","volume":"9","author":"Levy","year":"2018","journal-title":"Front Physiol"},{"key":"2024110513581773300_ref39","doi-asserted-by":"crossref","first-page":"646","DOI":"10.3389\/fphys.2018.00646","article-title":"Logical modeling and analysis of cellular regulatory networks with GINsim 3.0","volume":"9","author":"Naldi","year":"2018","journal-title":"Front Physiol"},{"key":"2024110513581773300_ref40","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1093\/bioinformatics\/btx123","article-title":"MaBoSS 2.0: An environment for stochastic Boolean modeling","volume":"33","author":"Stoll","year":"2017","journal-title":"Bioinformatics"},{"key":"2024110513581773300_ref41","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.3389\/fphys.2018.01605","article-title":"BioLQM: A java toolkit for the manipulation and conversion of logical qualitative models of biological networks","volume":"9","author":"Naldi","year":"2018","journal-title":"Front Physiol"},{"key":"2024110513581773300_ref42","doi-asserted-by":"crossref","first-page":"W169","DOI":"10.1093\/nar\/gkm415","article-title":"DAVID bioinformatics resources: Expanded annotation database and novel algorithms to better extract biology from large gene lists","volume":"35","author":"Huang","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"2024110513581773300_ref43","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13046-020-01639-2","article-title":"Hypoxia, metabolism, and the circadian clock: New links to overcome radiation resistance in high-grade gliomas","volume":"39","author":"Shen","year":"2020","journal-title":"J Exp Clin Cancer Res"},{"key":"2024110513581773300_ref44","doi-asserted-by":"crossref","first-page":"100018","DOI":"10.1016\/j.arres.2021.100018","article-title":"The role of circadian and redox rhythms in cancer hypoxia","volume":"3","author":"Omer","year":"2021","journal-title":"Adv Redox Res"},{"key":"2024110513581773300_ref45","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.3390\/cancers12061489","article-title":"c-Src and EGFR inhibition in molecular cancer therapy: What else can we improve?","volume":"12","author":"Belli","year":"2020","journal-title":"Cancer"},{"key":"2024110513581773300_ref46","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1038\/sj.onc.1208513","article-title":"HIF-1\u03b1, STAT3, CBP\/p300 and Ref-1\/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas","volume":"24","author":"Gray","year":"2005","journal-title":"Oncogene"},{"key":"2024110513581773300_ref47","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1038\/sj.onc.1205260","article-title":"Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis","volume":"21","author":"Niu","year":"2002","journal-title":"Oncogene"},{"key":"2024110513581773300_ref48","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1038\/emboj.2010.162","article-title":"Nanog, Gli, and p53: A new network of stemness in development and cancer","volume":"29","author":"Brandner","year":"2010","journal-title":"EMBO J"},{"key":"2024110513581773300_ref49","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.trecan.2019.07.002","article-title":"Interplay between circadian clock and cancer: New frontiers for cancer treatment","volume":"5","author":"Sulli","year":"2019","journal-title":"Trends in cancer"},{"key":"2024110513581773300_ref50","doi-asserted-by":"crossref","first-page":"10592","DOI":"10.1038\/s41598-017-09244-8","article-title":"Hypoxia-inducible factor 1 alpha promotes cancer stem cells-like properties in human ovarian cancer cells by upregulating SIRT1 expression","volume":"7","author":"Qin","year":"2017","journal-title":"Sci Rep"},{"key":"2024110513581773300_ref51","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cmet.2016.09.009","article-title":"Reciprocal regulation between the circadian clock and hypoxia signaling at the genome level in mammals","volume":"25","author":"Wu","year":"2017","journal-title":"Cell Metab"},{"key":"2024110513581773300_ref52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/ijo.2022.5439","article-title":"Circadian clock as a possible control point in colorectal cancer progression","volume":"61","author":"Rao","year":"2022","journal-title":"Int J Oncol"},{"key":"2024110513581773300_ref53","doi-asserted-by":"crossref","first-page":"24675","DOI":"10.18632\/aging.203708","article-title":"BMAL1 may be involved in angiogenesis and peritumoral cerebral edema of human glioma by regulating VEGF and ANG2","volume":"13","author":"Wang","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"2024110513581773300_ref54","doi-asserted-by":"crossref","first-page":"858694","DOI":"10.3389\/fonc.2022.858694","article-title":"RNA demethylase ALKBH5 prevents lung cancer progression by regulating EMT and stemness via regulating p53","volume":"12","author":"Liu","year":"2022","journal-title":"Front Oncol"},{"key":"2024110513581773300_ref55","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.canlet.2019.11.024","article-title":"Circadian clock gene NPAS2 promotes reprogramming of glucose metabolism in hepatocellular carcinoma cells","volume":"469","author":"Yuan","year":"2020","journal-title":"Cancer Lett"},{"key":"2024110513581773300_ref56","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1158\/2326-6066.CIR-21-0559","article-title":"Circadian regulator CLOCK drives immunosuppression in glioblastoma","volume":"10","author":"Xuan","year":"2022","journal-title":"Cancer Immunol Res"},{"key":"2024110513581773300_ref57","doi-asserted-by":"crossref","first-page":"4472","DOI":"10.1002\/cam4.5129","article-title":"BMAL1 promotes colorectal cancer cell migration and invasion through ERK-and JNK-dependent c-Myc expression","volume":"12","author":"Shan","year":"2023","journal-title":"Cancer Med"},{"key":"2024110513581773300_ref58","doi-asserted-by":"crossref","first-page":"112127","DOI":"10.1016\/j.celrep.2023.112127","article-title":"Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma","volume":"42","author":"Pang","year":"2023","journal-title":"Cell Rep"},{"key":"2024110513581773300_ref59","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.str.2014.12.014","article-title":"Insights into Cullin-RING E3 ubiquitin ligase recruitment: Structure of the VHL-EloBC-Cul2 complex","volume":"23","author":"Nguyen","year":"2015","journal-title":"Structure"},{"key":"2024110513581773300_ref60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0156-4","article-title":"CLOCK and BMAL1 stabilize and activate RHOA to promote F-actin formation in cancer cells","volume":"50","author":"Ma","year":"2018","journal-title":"Exp Mol Med"},{"key":"2024110513581773300_ref61","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ebiom.2019.07.004","article-title":"Aryl hydrocarbon receptor nuclear translocator-like (ARNTL\/BMAL1) is associated with bevacizumab resistance in colorectal cancer via regulation of vascular endothelial growth factor a","volume":"45","author":"Burgermeister","year":"2019","journal-title":"EBioMedicine"}],"container-title":["Integrative Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ib\/article-pdf\/doi\/10.1093\/intbio\/zyae018\/60423581\/zyae018.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ib\/article-pdf\/doi\/10.1093\/intbio\/zyae018\/60423581\/zyae018.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:58:44Z","timestamp":1730815124000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ib\/article\/doi\/10.1093\/intbio\/zyae018\/7876132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":61,"URL":"https:\/\/doi.org\/10.1093\/intbio\/zyae018","relation":{},"ISSN":["1757-9708"],"issn-type":[{"value":"1757-9708","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024]]},"published":{"date-parts":[[2024]]},"article-number":"zyae018"}}