{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:08:42Z","timestamp":1791385722645,"version":"4.3.3"},"reference-count":83,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This review addresses the critical issue of antibiotics and antibiotic resistance genes (ARGs) in Nigerian water systems, which pose significant public health and environmental challenges. Reported antibiotic concentrations in Nigerian surface waters was a maximum of 272.15\u2009\u03bcg\/L, frequently exceeding the World Health Organization (WHO) recommended safety limit of 72 out of 75 antibiotics. Sulfonamides, beta-lactams, tetracyclines, fluoroquinolones, carbapenems, and cephalosporins are the most common classes of antibiotics detected, with residues reported in &amp;gt;80% of surface water studies. Many ARGs such as beta-lactamase (bla), tetracycline (tet), and sulfonamide (sul) genes have been found in 70%\u201390% of water sources in Nigeria, and they are also common in Ghana. The prevalence of these antibiotics and ARGs in Nigerian water sources are linked to human and animal activities, including medical facilities, pharmaceutical industries, and agricultural practices. These sources contribute to the widespread distribution of ARGs, which are exacerbated by inadequate wastewater treatment and regulatory policies. The persistence of these contaminants threatens aquatic ecosystems and human health by promoting the spread of resistant infections. This article examines the sources, occurrence, and spatial distribution of antibiotics and ARGs in Nigeria, highlighting the mechanisms of ARG transmission and the factors influencing their spread. Additionally, it discusses the human health risks and ecological impacts associated with antibiotic contamination, underscoring the urgent need for effective intervention strategies. Addressing these issues is also vital for achieving sustainable developments, particularly those related to health, clean water, and life below water. The review calls for advanced wastewater treatment, regulatory improvements, and increased public awareness to mitigate the impact of antibiotics and ARGs on Nigerian water systems.<\/jats:p>","DOI":"10.1093\/inteam\/vjaf143","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:59:21Z","timestamp":1760551161000},"page":"388-402","source":"Crossref","is-referenced-by-count":13,"title":["Antibiotic resistance in Nigeria\u2019s water system: an urgent public health challenge impeding the achievement of Sustainable Development Goals (SDGs)"],"prefix":"10.1093","volume":"22","author":[{"given":"Emmanuel Sunday","family":"Okeke","sequence":"first","affiliation":[{"name":"Natural Science Unit, School of General Studies, University of Nigeria, Nsukka (UNN) , Enugu,","place":["Nigeria"]},{"name":"Department of Biochemistry, Faculty of Biological Science UNN , Enugu,","place":["Nigeria"]},{"name":"School of Pharmacy, Faculty of Sciences, University of Waterloo, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnbosco C","family":"Egbueri","sequence":"additional","affiliation":[{"name":"Department of Geology, Chukwuemeka Odumegwu Ojukwu University (COOU) , Uli,","place":["Nigeria"]},{"name":"Research Management Office (RMO), COOU , Uli, Anambra State,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen Sunday","family":"Emmanuel","sequence":"additional","affiliation":[{"name":"Department of Industrial Chemistry, Faculty of Physical Sciences, University of Ilorin , Ilorin,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan Chukwuemeka","family":"Ezeudoka","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu University , Zhenjiang,","place":["China"]},{"name":"School of Management, Jiangsu University , Zhenjiang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles Ogugua","family":"Nwuche","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Biological Science UNN , Nsukka, Enugu State,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica Chisom","family":"Okeke","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5055-0815","authenticated-orcid":false,"given":"Adebisi Esther","family":"Enochoghene","sequence":"additional","affiliation":[{"name":"Environmental Management and Toxicology Unit, Department of Biological Sciences, Lead City University (LCU) , Ibadan, 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