{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T21:07:35Z","timestamp":1788901655438,"version":"build-2803163510"},"reference-count":81,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union scientific research initiative","award":["881603"],"award-info":[{"award-number":["881603"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Graphene-related materials (GRMs) are revolutionizing sectors such as electronics, energy storage, agriculture, and biomedicine due to their exceptional properties. However, concerns are emerging about their environmental impact, particularly regarding their persistence, potential toxicity to aquatic ecosystems, and challenges in safe disposal. These issues highlight the need for more robust sustainable-by-design and risk-assessment strategies. In this context, this research investigated the influence of GRMs on lignin peroxidase (LiP) and laccase (Lac), key enzymes involved in lignin breakdown with significant potential in bioremediation. These enzymes are crucial for degrading complex molecules, and understanding their interaction with GRMs could provide valuable insights into the degradation of 2D nanomaterials, particularly graphene oxide (GO), few-layer graphene (FLG), and reduced graphene oxide (rGO). In vitro enzymatic assays conducted with varying GRMs concentrations (12.5, 25.0, and 50.0\u2009\u00b5g\/mL) revealed that Lac remained unaffected, while LiP exhibited a noteworthy reduction in catalytic activity, particularly in the presence of GO at the highest concentration. A sequestration study to quantify the bioavailable fraction confirmed these effects, indicating significant enzyme loss, notably with GO at 50\u2009\u00b5g\/mL. These findings prompted a mechanistic exploration of enzyme inhibition dynamics, revealing the complex nature of GRM-catalytic enzyme processes. By considering factors such as zeta potential (electrostatic forces), hydrophobicity, dispersion stability, and oxidation state, this study addresses a key knowledge gap and provides a foundation for understanding these interactions, offering crucial insights into the environmental fate of GRMs and guiding their sustainable use and management.<\/jats:p>","DOI":"10.1093\/inteam\/vjag003","type":"journal-article","created":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T04:45:14Z","timestamp":1768106714000},"page":"1514-1526","source":"Crossref","is-referenced-by-count":2,"title":["Comparative analysis of lignin peroxidase and laccase responses to graphene-related nanomaterials"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3460-8404","authenticated-orcid":false,"given":"Humberto","family":"Castillo-Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Department of Chemical and Pharmaceutical Sciences, University of Trieste , Trieste,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8277-4725","authenticated-orcid":false,"given":"Fabio","family":"Candotto Carniel","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, University of Trieste , Trieste,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5735-2363","authenticated-orcid":false,"given":"Mario","family":"Mardirossian","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, University of Trieste , Trieste,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3223-8024","authenticated-orcid":false,"given":"Ester","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Instituto Regional de Investigaci\u00f3n Cient\u00edfica Aplicada (IRICA), Universidad de Castilla-La Mancha, Avda. Camilo Jos\u00e9 Cela , Ciudad Real,","place":["Spain"]},{"name":"Departamento de Qu\u00edmica Inorg\u00e1nica, Org\u00e1nica y Bioqu\u00edmica, Facultad de Ciencias y Tecnolog\u00edas Qu\u00edmicas, Universidad de Castilla-La Mancha , Ciudad Real,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8869-8612","authenticated-orcid":false,"given":"Maurizio","family":"Prato","sequence":"additional","affiliation":[{"name":"Department of Chemical and Pharmaceutical Sciences, University of Trieste , Trieste,","place":["Italy"]},{"name":"Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA) , Donostia-San Sebasti\u00e1n,","place":["Spain"]},{"name":"Ikerbasque, Basque Foundation for Science , Bilbao,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0529-1359","authenticated-orcid":false,"given":"Mauro","family":"Tretiach","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, University of Trieste , Trieste,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,10]]},"reference":[{"key":"2026090816135663800_vjag003-B1","doi-asserted-by":"publisher","first-page":"4068","DOI":"10.3390\/w14244068","article-title":"Bacterial laccases as biocatalysts for the remediation of environmental toxic pollutants: A green and eco-friendly approach\u2014A review","volume":"14","author":"Agarwal","year":"2022","journal-title":"Water"},{"key":"2026090816135663800_vjag003-B2","doi-asserted-by":"publisher","first-page":"107327","DOI":"10.1016\/j.cclet.2022.03.050","article-title":"Aggregation of graphene oxide and its environmental implications in the aquatic environment","volume":"34","author":"Ali","year":"2023","journal-title":"Chinese Chemical Letters"},{"key":"2026090816135663800_vjag003-B3","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/s13068-019-1494-8","article-title":"Internalization and accumulation of model lignin breakdown products in bacteria and fungi","volume":"12","author":"Barnhart-Dailey","year":"2019","journal-title":"Biotechnology for Biofuels"},{"key":"2026090816135663800_vjag003-B4","doi-asserted-by":"publisher","first-page":"2200510","DOI":"10.1002\/admi.202200510","article-title":"High surface area \u201c3D graphene oxide\u201d for enhanced sorption of radionuclides","volume":"9","author":"Boulanger","year":"2022","journal-title":"Advanced Materials Interfaces"},{"key":"2026090816135663800_vjag003-B5","doi-asserted-by":"publisher","first-page":"125553","DOI":"10.1016\/j.jhazmat.2021.125553","article-title":"Graphene environmental biodegradation: Wood degrading and saprotrophic fungi oxidize few-layer graphene","volume":"414","author":"Candotto Carniel","year":"2021","journal-title":"Journal of Hazardous Materials"},{"key":"2026090816135663800_vjag003-B6","doi-asserted-by":"publisher","first-page":"117888","DOI":"10.1016\/j.ecoenv.2025.117888","article-title":"Applicability of the OECD Test Guideline 201 to graphene-related materials: Dispersion stability matters","volume":"292","author":"Caorsi","year":"2025","journal-title":"Ecotoxicology and Environmental Safety"},{"key":"2026090816135663800_vjag003-B7","doi-asserted-by":"publisher","first-page":"100506","DOI":"10.1016\/j.apmt.2019.100506","article-title":"Surface area measurements of graphene and graphene oxide samples: Dopamine adsorption as a complement or alternative to methylene blue?","volume":"18","author":"Chen","year":"2020","journal-title":"Applied Materials Today"},{"key":"2026090816135663800_vjag003-B8","doi-asserted-by":"publisher","first-page":"9382","DOI":"10.1021\/es5020828","article-title":"Interactions of graphene oxide nanomaterials with natural organic matter and metal oxide surfaces","volume":"48","author":"Chowdhury","year":"2014","journal-title":"Environmental Science & Technology"},{"key":"2026090816135663800_vjag003-B9","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.scitotenv.2015.01.077","article-title":"Effects of graphene oxides on soil enzyme activity and microbial biomass","volume":"514","author":"Chung","year":"2015","journal-title":"Science of the Total Environment"},{"key":"2026090816135663800_vjag003-B10","doi-asserted-by":"publisher","first-page":"2936","DOI":"10.1039\/d3en00511a","article-title":"Prospects of 2D graphene nanomaterials in plant-based agriculture and their fate in terrestrial soil: A critical review","volume":"10","author":"Das","year":"2023","journal-title":"Environmental Science: Nano"},{"key":"2026090816135663800_vjag003-B11","doi-asserted-by":"publisher","first-page":"101379","DOI":"10.1016\/j.nantod.2022.101379","article-title":"Environmental and health effects of graphene-family nanomaterials: Potential release pathways, transformation, environmental fate and health risks","volume":"42","author":"Ding","year":"2022","journal-title":"Nano Today"},{"key":"2026090816135663800_vjag003-B12","doi-asserted-by":"publisher","first-page":"3405","DOI":"10.3390\/molecules30163405","article-title":"Advanced technologies for wastewater treatment: Graphene-based catalysts","volume":"30","author":"Elgoyhen","year":"2025","journal-title":"Molecules"},{"key":"2026090816135663800_vjag003-B13","doi-asserted-by":"publisher","first-page":"623853","DOI":"10.3389\/fmicb.2021.623853","article-title":"Graphene-based nanomaterials modulate internal biofilm interactions and microbial diversity","volume":"12","author":"Evariste","year":"2021","journal-title":"Frontiers in Microbiology"},{"key":"2026090816135663800_vjag003-B14","doi-asserted-by":"publisher","first-page":"48450","DOI":"10.1021\/acsami.9b19183","article-title":"Ambient-temperature waterborne polymer\/rGO nanocomposite films: Effect of rGO distribution on electrical conductivity","volume":"11","author":"Fadil","year":"2019","journal-title":"ACS Applied Materials & Interfaces"},{"key":"2026090816135663800_vjag003-B15","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1039\/C7EN00396J","article-title":"Biodegradation of graphene oxide\u2013polymer nanocomposite films in wastewater","volume":"4","author":"Fan","year":"2017","journal-title":"Environmental Science: Nano"},{"key":"2026090816135663800_vjag003-B16","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1039\/C7EN00401J","article-title":"Environmental impact and potential health risks of 2D nanomaterials","volume":"4","author":"Fojt\u016f","year":"2017","journal-title":"Environmental Science: Nano"},{"key":"2026090816135663800_vjag003-B17","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.1039\/d3en00072a","article-title":"Graphene oxide degradation by a white-rot fungus occurs in spite of lignin peroxidase inhibition","volume":"10","author":"Fortuna","year":"2023","journal-title":"Environmental Science: Nano"},{"key":"2026090816135663800_vjag003-B18","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1039\/C9NH00494G","article-title":"Mechanochemical preparation of piezoelectric nanomaterials: BN, MoS2 and WS2 two-dimensional materials and their glycine cocrystals","volume":"5","author":"Gonz\u00e1lez","year":"2020","journal-title":"Nanoscale Horizons"},{"key":"2026090816135663800_vjag003-B19","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/nprot.2017.142","article-title":"Production of ready-to-use few-layer graphene in aqueous suspensions","volume":"13","author":"Gonz\u00e1lez-Dom\u00ednguez","year":"2018","journal-title":"Nature Protocols"},{"key":"2026090816135663800_vjag003-B20","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.aiepr.2023.03.001","article-title":"Graphene-based nanostructures from green processes and their applications in biomedical sensors","volume":"7","author":"Goodrum","year":"2024","journal-title":"Advanced Industrial and Engineering Polymer Research"},{"key":"2026090816135663800_vjag003-B21","doi-asserted-by":"publisher","first-page":"4491","DOI":"10.1021\/acs.est.7b04938","article-title":"Detection and quantification of graphene family nanomaterials in the environment","volume":"52","author":"Goodwin","year":"2018","journal-title":"Environmental Science & Technology"},{"key":"2026090816135663800_vjag003-B22","doi-asserted-by":"publisher","first-page":"19362","DOI":"10.1039\/C9NR01143A","article-title":"Defect-assisted protein HP35 denaturation on graphene","volume":"11","author":"Gu","year":"2019","journal-title":"Nanoscale"},{"key":"2026090816135663800_vjag003-B23","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/B978-0-323-52725-5.00005-8","volume-title":"Multifunctional systems for combined delivery, biosensing and diagnostics","author":"Gumustas","year":"2017"},{"key":"2026090816135663800_vjag003-B24","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.carbon.2013.09.024","article-title":"Porous structures in stacked, crumpled and pillared graphene-based 3D materials","volume":"66","author":"Guo","year":"2014","journal-title":"Carbon"},{"key":"2026090816135663800_vjag003-B25","doi-asserted-by":"publisher","first-page":"21020","DOI":"10.1021\/acsami.9b21841","article-title":"Graphene surfaces interaction with proteins, bacteria, mammalian cells, and blood constituents: The impact of graphene platelet oxidation and thickness","volume":"12","author":"Henriques","year":"2020","journal-title":"ACS Applied Materials & Interfaces"},{"key":"2026090816135663800_vjag003-B26","doi-asserted-by":"publisher","first-page":"21750","DOI":"10.1021\/acs.est.4c05153","article-title":"Form-specific prospective environmental risk assessment of graphene-based materials in European freshwater","volume":"58","author":"Hong","year":"2024","journal-title":"Environmental Science & Technology"},{"key":"2026090816135663800_vjag003-B27","doi-asserted-by":"publisher","first-page":"4702","DOI":"10.1074\/jbc.RA117.001153","article-title":"Fungal lignin peroxidase does not produce the veratryl alcohol cation radical as a diffusible ligninolytic oxidant","volume":"293","author":"Houtman","year":"2018","journal-title":"The Journal of Biological Chemistry"},{"key":"2026090816135663800_vjag003-B28","doi-asserted-by":"publisher","first-page":"3226","DOI":"10.1039\/D2EN00248E","article-title":"Construction of adsorbents with graphene and its derivatives for wastewater treatment: A review","volume":"9","author":"Hu","year":"2022","journal-title":"Environmental Science: Nano"},{"key":"2026090816135663800_vjag003-B29","doi-asserted-by":"publisher","first-page":"6468","DOI":"10.3390\/ma14216468","article-title":"Microwave-assisted coal-derived few-layer graphene as an anode material for lithium-ion batteries","volume":"14","author":"Islam","year":"2021","journal-title":"Materials"},{"key":"2026090816135663800_vjag003-B30","doi-asserted-by":"publisher","first-page":"6964","DOI":"10.1021\/acs.est.6b00810","article-title":"Graphene oxides in water: Correlating morphology and surface chemistry with aggregation behavior","volume":"50","author":"Jiang","year":"2016","journal-title":"Environmental Science & Technology"},{"key":"2026090816135663800_vjag003-B31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7324\/ijcrr.2017.9211","article-title":"Lignocellulose degrading enzymes from fungi and their industrial applications","volume":"9","author":"Kantharaj","year":"2017","journal-title":"International Journal of Current Research and Review"},{"key":"2026090816135663800_vjag003-B32","doi-asserted-by":"publisher","first-page":"114941","DOI":"10.1016\/j.mseb.2020.114941","article-title":"The influence of annealing on a large specific surface area and enhancing electrochemical properties of reduced graphene oxide to improve the performance of the active electrode of supercapacitor devices","volume":"264","author":"Karaphun","year":"2021","journal-title":"Materials Science and Engineering: B"},{"key":"2026090816135663800_vjag003-B33","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1021\/ez400106t","article-title":"Predicted releases of engineered nanomaterials: From global to regional to local","volume":"1","author":"Keller","year":"2014","journal-title":"Environmental Science & Technology Letters"},{"key":"2026090816135663800_vjag003-B34","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/cnma.201600290","article-title":"Biocompatibility and nanotoxicity of layered two-dimensional nanomaterials","volume":"3","author":"Kenry","year":"2017","journal-title":"ChemNanoMat"},{"key":"2026090816135663800_vjag003-B35","doi-asserted-by":"publisher","first-page":"e03170","DOI":"10.1016\/j.heliyon.2020.e03170","article-title":"Ligninolytic enzymes and mechanisms for degradation of lignocellulosic waste in the environment","volume":"6","author":"Kumar","year":"2020","journal-title":"Heliyon"},{"key":"2026090816135663800_vjag003-B36","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s42004-019-0254-9","article-title":"Linking graphene-based material physicochemical properties with molecular adsorption, structure and cell fate","volume":"3","author":"Kumar","year":"2020","journal-title":"Communications Chemistry"},{"key":"2026090816135663800_vjag003-B37","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1016\/j.ijbiomac.2020.09.099","article-title":"Time-dependent study of the graphene oxide\u2013trypsin adsorption interface and visualization of nano-protein corona","volume":"163","author":"Kumari","year":"2020","journal-title":"International Journal of Biological Macromolecules"},{"key":"2026090816135663800_vjag003-B38","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.cej.2013.08.050","article-title":"Large-scale production of high-quality reduced graphene oxide","volume":"233","author":"Lee","year":"2013","journal-title":"Chemical Engineering Journal"},{"key":"2026090816135663800_vjag003-B39","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3390\/c10030078","article-title":"Research progress in graphene-based adsorbents for wastewater treatment: Preparation, adsorption properties and mechanisms for inorganic and organic pollutants","volume":"10","author":"Li","year":"2024","journal-title":"C"},{"key":"2026090816135663800_vjag003-B40","doi-asserted-by":"publisher","first-page":"105672","DOI":"10.1016\/j.supflu.2022.105672","article-title":"Graphene-based materials prepared by supercritical fluid technology and applications in energy storage","volume":"188","author":"Liu","year":"2022","journal-title":"The Journal of Supercritical Fluids"},{"key":"2026090816135663800_vjag003-B41","doi-asserted-by":"publisher","first-page":"16737","DOI":"10.1021\/acs.est.2c03342","article-title":"Biodegradation of graphene oxide by insects (Tenebrio molitor larvae): Role of the gut microbiome and enzymes","volume":"56","author":"Liu","year":"2022","journal-title":"Environmental Science & Technology"},{"key":"2026090816135663800_vjag003-B42","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.bios.2016.07.024","article-title":"Interactions between avidin and graphene for development of a biosensing platform","volume":"89","author":"Macwan","year":"2017","journal-title":"Biosensors & Bioelectronics"},{"key":"2026090816135663800_vjag003-B43","doi-asserted-by":"publisher","first-page":"177","DOI":"10.7240\/jeps.1174562","article-title":"Evaluation of potential environmental risks of graphene-based materials by examining the effect of rGO on the microbial activity of","volume":"35","author":"Madenli","year":"2023","journal-title":"International Journal of Advances in Engineering and Pure Sciences"},{"key":"2026090816135663800_vjag003-B44","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1039\/C9NA00807A","article-title":"Modulation of protein\u2013graphene oxide interactions with varying degrees of oxidation","volume":"2","author":"Malik","year":"2020","journal-title":"Nanoscale Advances"},{"key":"2026090816135663800_vjag003-B45","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.3390\/cryst13101413","article-title":"Graphene production and biomedical applications: A review","volume":"13","author":"Malisz","year":"2023","journal-title":"Crystals"},{"key":"2026090816135663800_vjag003-B46","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1039\/C8EN00138C","article-title":"Combined toxicity of graphene oxide and wastewater to the green alga","volume":"5","author":"Mart\u00edn-De-Luc\u00eda","year":"2018","journal-title":"Environmental Science: Nano"},{"key":"2026090816135663800_vjag003-B47","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1039\/D1GC03854K","article-title":"Depolymerization of lignin for biological conversion through sulfonation and a chelator-mediated Fenton reaction","volume":"24","author":"Martinez","year":"2022","journal-title":"Green Chemistry"},{"key":"2026090816135663800_vjag003-B48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijbiomac.2021.01.152","article-title":"Biological effects of formation of protein corona onto nanoparticles","volume":"175","author":"Mishra","year":"2021","journal-title":"International Journal of Biological Macromolecules"},{"key":"2026090816135663800_vjag003-B49","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1002\/adfm.202105649","article-title":"Biodegradation of carbon-based nanomaterials: The importance of biomolecular corona consideration","volume":"32","author":"Mokhtari-Farsani","year":"2022","journal-title":"Advanced Functional Materials"},{"key":"2026090816135663800_vjag003-B50","doi-asserted-by":"publisher","first-page":"2858","DOI":"10.3390\/nano13212858","article-title":"Ecotoxicity assessment of graphene oxides using test organisms from three hierarchical trophic levels to evaluate their potential environmental risk","volume":"13","author":"N\u00e9meth","year":"2023","journal-title":"Nanomaterials"},{"key":"2026090816135663800_vjag003-B51","doi-asserted-by":"publisher","first-page":"3","DOI":"10.30919\/es8d128906","article-title":"Graphene- and graphene oxide\u2013based membranes for gas separation","volume":"9","author":"Nidamanuri","year":"2020","journal-title":"Engineered Science"},{"key":"2026090816135663800_vjag003-B52","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1093\/bulcsj\/uoae118","article-title":"Refined surface area determination of graphene oxide using methylene blue as a probe molecule: A comparative approach","volume":"97","author":"Ortiz-Anaya","year":"2024","journal-title":"Bulletin of the Chemical Society of Japan"},{"key":"2026090816135663800_vjag003-B53","doi-asserted-by":"publisher","first-page":"116015","DOI":"10.1016\/j.ecoenv.2024.116015","article-title":"Assessment of co-contaminated soil amended by graphene oxide: Effects on pollutants, microbial communities and soil health","volume":"272","author":"Pe\u00f1a-\u00c1lvarez","year":"2024","journal-title":"Ecotoxicology and Environmental Safety"},{"key":"2026090816135663800_vjag003-B54","doi-asserted-by":"publisher","first-page":"15239","DOI":"10.1038\/s41598-017-15463-w","article-title":"Large area few-layer graphene with scalable preparation from waste biomass for high-performance supercapacitor","volume":"7","author":"Purkait","year":"2017","journal-title":"Scientific Reports"},{"key":"2026090816135663800_vjag003-B55","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.watres.2018.03.070","article-title":"A novel environmental fate of graphene oxide: Biodegradation by a bacterium Labrys sp. WJW to support growth","volume":"143","author":"Qu","year":"2018","journal-title":"Water Research"},{"key":"2026090816135663800_vjag003-B56","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1186\/s12951-023-02030-x","article-title":"The influence of protein corona on graphene oxide: Implications for biomedical theranostics","volume":"21","author":"Quagliarini","year":"2023","journal-title":"Journal of Nanobiotechnology"},{"key":"2026090816135663800_vjag003-B57","doi-asserted-by":"publisher","first-page":"124911","DOI":"10.1063\/1.3079096","article-title":"A theoretical study on the interaction of aromatic amino acids with graphene and single-walled carbon nanotubes","volume":"130","author":"Rajesh","year":"2009","journal-title":"The Journal of Chemical Physics"},{"key":"2026090816135663800_vjag003-B58","doi-asserted-by":"publisher","first-page":"031001","DOI":"10.1116\/6.0004504","article-title":"Surface potential modulates fibronectin adsorption and molecular interaction on graphene-based materials","volume":"20","author":"Rohit","year":"2025","journal-title":"Biointerphases"},{"key":"2026090816135663800_vjag003-B59","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1477-3155-11-26","article-title":"Interaction of nanoparticles with proteins: Relation to bio-reactivity of the nanoparticle","volume":"11","author":"Saptarshi","year":"2013","journal-title":"Journal of Nanobiotechnology"},{"key":"2026090816135663800_vjag003-B60","doi-asserted-by":"publisher","first-page":"1132233","DOI":"10.3389\/fchem.2023.1132233","article-title":"Environmentally sustainable implementations of two-dimensional nanomaterials","volume":"11","author":"Shams","year":"2023","journal-title":"Frontiers in Chemistry"},{"key":"2026090816135663800_vjag003-B61","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/B978-0-12-814427-5.00015-9","volume-title":"Biomaterials and bionanotechnology","author":"Shnoudeh","year":"2019"},{"key":"2026090816135663800_vjag003-B62","doi-asserted-by":"publisher","first-page":"38654","DOI":"10.1039\/D0RA07961H","article-title":"Interactions, electronic and optical properties of nanographene\u2013peptide complexes: A theoretical study","volume":"10","author":"Srivastava","year":"2020","journal-title":"RSC Advances"},{"key":"2026090816135663800_vjag003-B63","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.cej.2013.07.123","article-title":"Direct production of highly conductive graphene with a low oxygen content by a microwave-assisted solvothermal method","volume":"232","author":"Van Khai","year":"2013","journal-title":"Chemical Engineering Journal"},{"key":"2026090816135663800_vjag003-B64","doi-asserted-by":"publisher","first-page":"163242","DOI":"10.1155\/2014\/163242","article-title":"Fungal laccases and their applications in bioremediation","volume":"2014","author":"Viswanath","year":"2014","journal-title":"Enzyme Research"},{"key":"2026090816135663800_vjag003-B65","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.micromeso.2015.01.014","article-title":"Comparative pore structure analysis of highly porous graphene monoliths treated at different temperatures with adsorption of N2 at 77.4 K and Ar at 87.3 K and 77.4 K","volume":"209","author":"Wang","year":"2015","journal-title":"Microporous and Mesoporous Materials"},{"key":"2026090816135663800_vjag003-B66","doi-asserted-by":"publisher","first-page":"6349","DOI":"10.1039\/d3na00696d","article-title":"The gut microbiome meets nanomaterials: Exposure and interplay with graphene nanoparticles","volume":"5","author":"Wojciechowska","year":"2023","journal-title":"Nanoscale Advances"},{"key":"2026090816135663800_vjag003-B67","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.chemosphere.2016.02.097","article-title":"Toxicity of graphene oxide to white-rot fungus","volume":"151","author":"Xie","year":"2016","journal-title":"Chemosphere"},{"key":"2026090816135663800_vjag003-B68","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.3390\/biom11101399","article-title":"Surface modulation of graphene oxide for amidase immobilization with high loadings for efficient biocatalysis","volume":"11","author":"Xu","year":"2021","journal-title":"Biomolecules"},{"key":"2026090816135663800_vjag003-B69","doi-asserted-by":"publisher","first-page":"5026","DOI":"10.1039\/C7RA12364G","article-title":"Influence of reduced graphene oxide on the growth, structure and decomposition activity of white-rot fungus","volume":"8","author":"Yang","year":"2018","journal-title":"RSC Advances"},{"key":"2026090816135663800_vjag003-B70","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.chemosphere.2018.10.115","article-title":"Fungal transformation of graphene by white-rot fungus","volume":"216","author":"Yang","year":"2019","journal-title":"Chemosphere"},{"key":"2026090816135663800_vjag003-B71","doi-asserted-by":"publisher","first-page":"100514","DOI":"10.1016\/j.colcom.2021.100514","article-title":"Protein corona reduced graphene oxide cytotoxicity by inhibiting endocytosis","volume":"45","author":"Yang","year":"2021","journal-title":"Colloid and Interface Science Communications"},{"key":"2026090816135663800_vjag003-B72","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1080\/17435390.2018.1458342","article-title":"Toxicity of mixtures of zinc oxide and graphene oxide nanoparticles to aquatic organisms of different trophic levels: Particles outperform dissolved ions","volume":"12","author":"Ye","year":"2018","journal-title":"Nanotoxicology"},{"key":"2026090816135663800_vjag003-B73","doi-asserted-by":"publisher","first-page":"15328","DOI":"10.1039\/d0ra01068e","article-title":"Progress in the functional modification of graphene\/graphene oxide: A review","volume":"10","author":"Yu","year":"2020","journal-title":"RSC Advances"},{"key":"2026090816135663800_vjag003-B74","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.carbon.2015.07.036","article-title":"Reduced graphene oxide enhances horseradish peroxidase stability by serving as radical scavenger and redox mediator","volume":"94","author":"Zhang","year":"2015","journal-title":"Carbon"},{"key":"2026090816135663800_vjag003-B75","doi-asserted-by":"publisher","first-page":"7918","DOI":"10.1021\/es5011175","article-title":"Manganese peroxidase degrades pristine but not surface-oxidized (carboxylated) single-walled carbon nanotubes","volume":"48","author":"Zhang","year":"2014","journal-title":"Environmental Science & Technology"},{"key":"2026090816135663800_vjag003-B76","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.cej.2018.10.064","article-title":"Unraveling the molecular interaction mechanism between graphene oxide and aromatic organic compounds with implications on wastewater treatment","volume":"358","author":"Zhang","year":"2019","journal-title":"Chemical Engineering Journal"},{"key":"2026090816135663800_vjag003-B77","doi-asserted-by":"publisher","first-page":"135350","DOI":"10.1016\/j.jhazmat.2024.135350","article-title":"Microbial response to the chronic toxicity effect of graphene and graphene oxide nanomaterials within aerobic granular sludge systems","volume":"477","author":"Zhang","year":"2024","journal-title":"Journal of Hazardous Materials"},{"key":"2026090816135663800_vjag003-B78","doi-asserted-by":"publisher","first-page":"e01355-21","DOI":"10.1128\/AEM.01355-21","article-title":"Isolation and characterization of a novel laccase for lignin degradation, LacZ1","volume":"87","author":"Zhang","year":"2021","journal-title":"Applied and Environmental Microbiology"},{"key":"2026090816135663800_vjag003-B79","doi-asserted-by":"publisher","first-page":"936","DOI":"10.3390\/nano12060936","article-title":"The effects of graphene-family nanomaterials on plant growth: A review","volume":"12","author":"Zhang","year":"2022","journal-title":"Nanomaterials"},{"key":"2026090816135663800_vjag003-B80","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1080\/10643389.2020.1764279","article-title":"Engineered nanomaterials in the environment: Are they safe?","volume":"51","author":"Zhao","year":"2021","journal-title":"Critical Reviews in Environmental Science and Technology"},{"key":"2026090816135663800_vjag003-B81","doi-asserted-by":"publisher","first-page":"3693","DOI":"10.1039\/D4EN00143E","article-title":"Challenges and prospects: Graphene oxide\u2013based materials for water remediation including metal ions and organic pollutants","volume":"11","author":"Zubair","year":"2024","journal-title":"Environmental Science: Nano"}],"container-title":["Integrated Environmental Assessment and Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ieam\/advance-article-pdf\/doi\/10.1093\/inteam\/vjag003\/66341722\/vjag003.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ieam\/article-pdf\/22\/5\/1514\/66341722\/vjag003.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ieam\/article-pdf\/22\/5\/1514\/66341722\/vjag003.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:14:10Z","timestamp":1788898450000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ieam\/article\/22\/5\/1514\/8419874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,10]]},"references-count":81,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,1,10]]},"published-print":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/inteam\/vjag003","relation":{},"ISSN":["1551-3777","1551-3793"],"issn-type":[{"value":"1551-3777","type":"print"},{"value":"1551-3793","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,1,10]]}}}