{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:30:46Z","timestamp":1793406646036,"version":"4.5.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"am","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Polish National Science Center","award":["2020\/39\/D\/NZ8\/02399"],"award-info":[{"award-number":["2020\/39\/D\/NZ8\/02399"]}],"id":[{"id":"https:\/\/ror.org\/03ha2q922","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Remote ecosystems are often assumed to be insulated from chemical contamination; however, increasing human visitation may compromise this perception. We evaluated the occurrence, spatial distribution, and ecological implications of pharmaceutical active compounds in soils from the summit of Roraima-tepui, a high-elevation \u201csky island\u201d in the Guiana Shield subjected to unregulated tourism and lacking sanitation infrastructure. Surface soils from anthropogenically influenced and naturogenic zones were analyzed for 98 pharmaceuticals using high-performance liquid chromatography coupled to tandem mass spectrometry, and potential risks were evaluated by environmental risk quotient, cumulative and mixture-based approaches, and antimicrobial resistance\u2013specific thresholds. Eleven pharmaceuticals were detected, including antibiotics, antifungals, analgesics, and psychoactive compounds. Compounds associated with direct human use (e.g., ciprofloxacin, clarithromycin, acetaminophen) were primarily confined to anthropogenic areas, whereas others (notably fleroxacin, thiabendazole, pregabalin, and sulfadimethoxine) occurred more widely, including naturogenic zones. These patterns suggest that heterogeneous inputs, compound-specific behavior, intense rainfall, and shallow sandstone soils may interact to redistribute contaminants beyond their initial points of introduction. Ciprofloxacin reached concentrations up to 186\u2009ng g\u22121 and contributed substantially to cumulative environmental risk estimates. Several compounds exceeded predicted no-effect concentrations, and screening-level cumulative environmental risk quotient values indicated elevated potential environmental risk. Antimicrobial resistance assessment suggested pronounced selection potential for ciprofloxacin in tourist-impacted areas, although resistance genes or resistant bacteria were not directly measured. These findings indicate that tourism-related pharmaceutical residues can occur in remote high-elevation protected ecosystems under tourism pressure, highlighting the need to integrate emerging contaminants into conservation and visitor management frameworks.<\/jats:p>","DOI":"10.1093\/inteam\/vjag158","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:28:06Z","timestamp":1791430086000},"source":"Crossref","is-referenced-by-count":0,"title":["Remote but not pristine anymore: Pharmaceutical pollution challenges management of a high-elevation protected ecosystem"],"prefix":"10.1093","author":[{"given":"Philippe J R","family":"Kok","sequence":"first","affiliation":[{"name":"Department of Ecology and Vertebrate Zoology, Faculty of Biology and Environmental Protection, University of Lodz , \u0141\u00f3d\u017a,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5118-4530","authenticated-orcid":false,"given":"Magdalena","family":"Urbaniak","sequence":"additional","affiliation":[{"name":"UNESCO Chair on Ecohydrology and Applied Ecology, Faculty of Biology and Environmental Protection, University of Lodz , \u0141\u00f3d\u017a,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartosz","family":"K\u00f3zka","sequence":"additional","affiliation":[{"name":"Department of Drug Chemistry, Pharmaceutical and Biomedical Analysis, Faculty of Pharmacy, Medical University of Warsaw , Warsaw,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Giebu\u0142towicz","sequence":"additional","affiliation":[{"name":"Department of Drug Chemistry, Pharmaceutical and Biomedical Analysis, Faculty of Pharmacy, Medical University of Warsaw , Warsaw,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"2026103019465688500_vjag158-B1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1039\/C9EM00463G","article-title":"Emerging investigator series: Use of behavioural endpoints in the regulation of chemicals","volume":"22","author":"\u00c5gerstrand","year":"2020","journal-title":"Environmental Science: Processes & Impacts"},{"key":"2026103019465688500_vjag158-B2","doi-asserted-by":"publisher","first-page":"20130492","DOI":"10.1098\/rsbl.2013.0492","article-title":"Assessing the exposure risk and impacts of pharmaceuticals in the environment on individuals and ecosystems","volume":"9","author":"Arnold","year":"2013","journal-title":"Biology Letters"},{"key":"2026103019465688500_vjag158-B3","doi-asserted-by":"publisher","first-page":"118640","DOI":"10.1016\/j.ecoenv.2025.118640","article-title":"Thermodynamic modelling of pharmaceutical sorption in soil systems: A comparative study of batch and fixed-bed approaches","volume":"302","author":"Bauer","year":"2025","journal-title":"Ecotoxicology and Environmental Safety"},{"key":"2026103019465688500_vjag158-B4","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1002\/etc.5528","article-title":"Do pharmaceuticals in the environment pose a risk to wildlife?","volume":"43","author":"Bean","year":"2024","journal-title":"Environmental Toxicology and Chemistry"},{"key":"2026103019465688500_vjag158-B5","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1007\/s42452-025-07716-5","article-title":"Occurrence and detection of selected pharmaceuticals of emerging concern: Potential risks for aquatic ecosystems and human health","volume":"7","author":"Belle","year":"2025","journal-title":"Discover Applied Sciences"},{"key":"2026103019465688500_vjag158-B6","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.envint.2015.10.015","article-title":"Concentrations of antibiotics predicted to select for resistant bacteria: Proposed limits for environmental regulation","volume":"86","author":"Bengtsson-Palme","year":"2016","journal-title":"Environment International"},{"key":"2026103019465688500_vjag158-B7","first-page":"161","volume-title":"Flora of the Venezuelan Guayana: Vol. 1. Introduction","author":"Berry","year":"1995"},{"key":"2026103019465688500_vjag158-B8","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.1002\/etc.5973","article-title":"Pharmaceutical pollution of the English national parks","volume":"43","author":"Boxall","year":"2024","journal-title":"Environmental Toxicology and Chemistry"},{"key":"2026103019465688500_vjag158-B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4614-3137-4_1","volume-title":"Reviews of environmental contamination and toxicology","author":"Brausch","year":"2012"},{"key":"2026103019465688500_vjag158-B10","doi-asserted-by":"publisher","first-page":"155193","DOI":"10.1016\/j.apsusc.2022.155193","article-title":"Degradation of ciprofloxacin by green cobalt oxide quantum dots","volume":"609","author":"Bronzato","year":"2023","journal-title":"Applied Surface Science"},{"key":"2026103019465688500_vjag158-B11","doi-asserted-by":"publisher","first-page":"109606","DOI":"10.1016\/j.envint.2025.109606","article-title":"Assessing the risk of antimicrobial resistance and potential environmental harm through national-scale surveillance of antimicrobials in hospital and community wastewater","volume":"202","author":"Byrnes","year":"2025","journal-title":"Environment International"},{"key":"2026103019465688500_vjag158-B12","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/B978-0-323-39307-2.00002-3","volume-title":"Pharmacology and therapeutics for dentistry","author":"Dowd","year":"2017","edition":"7th ed"},{"key":"2026103019465688500_vjag158-B13","author":"European Union","year":"2017"},{"key":"2026103019465688500_vjag158-B14","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/s10482-016-0658-9","article-title":"Evidence of Helicobacter spp. in freshwaters from Roraima Tepui, Guayana Shield, South America","volume":"109","author":"Fern\u00e1ndez-Delgado","year":"2016","journal-title":"Antonie Van Leeuwenhoek"},{"key":"2026103019465688500_vjag158-B15","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1093\/cid\/cit355","article-title":"The scourge of antibiotic resistance: The important role of the environment","volume":"57","author":"Finley","year":"2013","journal-title":"Clinical Infectious Diseases"},{"key":"2026103019465688500_vjag158-B16","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.3390\/molecules25061470","article-title":"Environmental risk and risk of resistance selection due to antimicrobials\u2019 occurrence in two Polish wastewater treatment plants and receiving surface water","volume":"25","author":"Giebu\u0142towicz","year":"2020","journal-title":"Molecules"},{"key":"2026103019465688500_vjag158-B17","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jhazmat.2011.10.004","article-title":"Biodegradation of ciprofloxacin in water and soil and its effects on the microbial communities","volume":"198","author":"Girardi","year":"2011","journal-title":"Journal of Hazardous Materials"},{"key":"2026103019465688500_vjag158-B18","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.chemosphere.2019.06.200","article-title":"Single and mixture toxicity of four pharmaceuticals of environmental concern to aquatic organisms, including a behavioral assessment","volume":"235","author":"Godoy","year":"2019","journal-title":"Chemosphere"},{"key":"2026103019465688500_vjag158-B19","doi-asserted-by":"publisher","first-page":"122353","DOI":"10.1016\/j.watres.2024.122353","article-title":"A multi-pronged approach to assessing antimicrobial resistance risks in coastal waters and aquaculture systems","volume":"266","author":"Goh","year":"2024","journal-title":"Water Research"},{"key":"2026103019465688500_vjag158-B20","doi-asserted-by":"publisher","first-page":"375","DOI":"10.5004\/dwt.2020.25325","article-title":"Occurrence of pharmaceuticals in aquatic environment\u2014A review","volume":"184","author":"Gworek","year":"2020","journal-title":"Desalination and Water Treatment"},{"key":"2026103019465688500_vjag158-B21","doi-asserted-by":"publisher","first-page":"107488","DOI":"10.1016\/j.envint.2022.107488","article-title":"Predicting selection for antimicrobial resistance in UK wastewater and aquatic environments: Ciprofloxacin poses a significant risk","volume":"169","author":"Hayes","year":"2022","journal-title":"Environment International"},{"key":"2026103019465688500_vjag158-B22","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s11104-009-0068-0","article-title":"OCBIL theory: Towards an integrated understanding of the evolution, ecology and conservation of biodiversity on old, climatically buffered, infertile landscapes","volume":"322","author":"Hopper","year":"2009","journal-title":"Plant and Soil"},{"key":"2026103019465688500_vjag158-B23","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s12862-024-02314-2","article-title":"Lost in space and time: Robust demography and enhanced resilience buffer adverse environmental effects in a highly isolated and sedentary pre-Pleistocene landscape vertebrate","volume":"24","author":"Kok","year":"2024","journal-title":"BMC Ecology and Evolution"},{"key":"2026103019465688500_vjag158-B24","doi-asserted-by":"publisher","first-page":"e12902","DOI":"10.1111\/conl.12902","article-title":"Tourism may threaten wildlife disease refugia","volume":"15","author":"Kok","year":"2022","journal-title":"Conservation Letters"},{"key":"2026103019465688500_vjag158-B25","doi-asserted-by":"publisher","first-page":"ycaf239","DOI":"10.1093\/ismeco\/ycaf239","article-title":"Lost paradise\u2014Anthropogenic pressure alters microbial functional diversity in an endangered endemic toad-habitat system","volume":"5","author":"Kok","year":"2025","journal-title":"ISME Communications"},{"key":"2026103019465688500_vjag158-B26","doi-asserted-by":"publisher","first-page":"106083","DOI":"10.1016\/j.envint.2020.106083","article-title":"Selective concentrations for trimethoprim resistance in aquatic environments","volume":"144","author":"Kraupner","year":"2020","journal-title":"Environment International"},{"key":"2026103019465688500_vjag158-B27","author":"Krupka","year":"1999"},{"key":"2026103019465688500_vjag158-B28","doi-asserted-by":"publisher","first-page":"154446","DOI":"10.1016\/j.scitotenv.2022.154446","article-title":"The assessment of environmental risk related to the occurrence of pharmaceuticals in bottom sediments of the Odra River estuary (SW Baltic Sea)","volume":"828","author":"Kucharski","year":"2022","journal-title":"Science of the Total Environment"},{"key":"2026103019465688500_vjag158-B29","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.chemosphere.2008.12.006","article-title":"Antibiotics in the aquatic environment: A review\u2014Part II","volume":"75","author":"K\u00fcmmerer","year":"2009","journal-title":"Chemosphere"},{"key":"2026103019465688500_vjag158-B30","doi-asserted-by":"publisher","first-page":"5293","DOI":"10.1021\/acs.est.4c13781","article-title":"Bioaccumulation of pharmaceutically active compounds from treated urban wastewaters in aquatic insect larvae and aerial adults","volume":"59","author":"Let","year":"2025","journal-title":"Environmental Science & Technology"},{"key":"2026103019465688500_vjag158-B31","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.envint.2018.03.034","article-title":"Chronic exposure to low environmental concentrations and legal aquaculture doses of antibiotics cause systemic adverse effects in Nile tilapia and provoke differential human health risk","volume":"115","author":"Limbu","year":"2018","journal-title":"Environment International"},{"key":"2026103019465688500_vjag158-B32","doi-asserted-by":"publisher","first-page":"5285","DOI":"10.1007\/s11356-016-8268-7","article-title":"Modulation of erythromycin-induced biochemical responses in crucian carp by ketoconazole","volume":"24","author":"Liu","year":"2017","journal-title":"Environmental Science and Pollution Research International"},{"key":"2026103019465688500_vjag158-B33","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.marpolbul.2017.10.010","article-title":"Distribution, sources, and ecological risk assessment of quinotone antibiotics in the surface sediments from Jiaozhou Bay wetland, China","volume":"129","author":"Liu","year":"2018","journal-title":"Marine Pollution Bulletin"},{"key":"2026103019465688500_vjag158-B34","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s40264-024-01497-3","article-title":"Call to action: Pharmaceutical residues in the environment\u2014Threats to ecosystems and human health","volume":"48","author":"Lunghi","year":"2025","journal-title":"Drug Safety"},{"key":"2026103019465688500_vjag158-B35","doi-asserted-by":"publisher","first-page":"100986","DOI":"10.1016\/j.hazadv.2025.100986","article-title":"Risk assessment and management of antimicrobial resistance in clinical and aquatic environments related to pandemics: A review","volume":"21","author":"Lyu","year":"2026","journal-title":"Journal of Hazardous Materials Advances"},{"key":"2026103019465688500_vjag158-B36","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1016\/j.envpol.2009.05.051","article-title":"Environmental pollution by antibiotics and by antibiotic resistance determinants","volume":"157","author":"Martinez","year":"2009","journal-title":"Environmental Pollution"},{"key":"2026103019465688500_vjag158-B37","doi-asserted-by":"publisher","first-page":"116969","DOI":"10.1016\/j.jece.2025.116969","article-title":"Systematic review of ciprofloxacin\u2019s occurrence and ecotoxicity in agricultural soil: An urgent call for food security","volume":"13","author":"Martins","year":"2025","journal-title":"Journal of Environmental Chemical Engineering"},{"key":"2026103019465688500_vjag158-B38","first-page":"269","article-title":"The origin of the bird fauna of the south Venezuelan highlands","volume":"136","author":"Mayr","year":"1967","journal-title":"Bulletin of the American Museum of Natural History"},{"key":"2026103019465688500_vjag158-B39","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.envint.2019.01.034","article-title":"Understanding drivers of antibiotic resistance genes in High Arctic soil ecosystems","volume":"125","author":"McCann","year":"2019","journal-title":"Environment International"},{"key":"2026103019465688500_vjag158-B40","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.envpol.2011.11.029","article-title":"Uptake and depuration of pharmaceuticals in aquatic invertebrates","volume":"165","author":"Meredith-Williams","year":"2012","journal-title":"Environmental Pollution"},{"key":"2026103019465688500_vjag158-B41","doi-asserted-by":"publisher","first-page":"108670","DOI":"10.1016\/j.cbpc.2019.108670","article-title":"Acute exposure of zebrafish (Danio rerio) larvae to environmental concentrations of selected antidepressants: Bioaccumulation, physiological and histological changes","volume":"229","author":"Nowakowska","year":"2020","journal-title":"Comparative Biochemistry and Physiology: Toxicology & Pharmacology"},{"key":"2026103019465688500_vjag158-B42","volume-title":"Tackling drug-resistant infections globally: Final report and recommendations","author":"O\u2019Neill","year":"2016"},{"key":"2026103019465688500_vjag158-B43","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.etap.2017.01.021","article-title":"Ecotoxicity of veterinary enrofloxacin and ciprofloxacin antibiotics on anuran amphibian larvae","volume":"51","author":"Peltzer","year":"2017","journal-title":"Environmental Toxicology and Pharmacology"},{"key":"2026103019465688500_vjag158-B44","doi-asserted-by":"publisher","first-page":"152884","DOI":"10.1016\/j.scitotenv.2021.152884","article-title":"Veterinary pharmaceuticals as a threat to endangered taxa: Mitigation action for vulture conservation","volume":"817","author":"Plaza","year":"2022","journal-title":"The Science of the Total Environment"},{"key":"2026103019465688500_vjag158-B45","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.ecoenv.2019.05.051","article-title":"Occurrence and potential human health risk of pharmaceutical residues in drinking water from Putrajaya (Malaysia)","volume":"180","author":"Praveena","year":"2019","journal-title":"Ecotoxicology and Environmental Safety"},{"key":"2026103019465688500_vjag158-B46","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1289\/ehp.1206446","article-title":"Management options for reducing the release of antibiotics and antibiotic resistance genes to the environment","volume":"121","author":"Pruden","year":"2013","journal-title":"Environmental Health Perspectives"},{"key":"2026103019465688500_vjag158-B47","doi-asserted-by":"publisher","first-page":"129012","DOI":"10.1016\/j.chemosphere.2020.129012","article-title":"Accumulation of human pharmaceuticals and activity of biotransformation enzymes in fish from two areas of the lower Rio de la Plata Basin","volume":"266","author":"Rojo","year":"2021","journal-title":"Chemosphere"},{"key":"2026103019465688500_vjag158-B48","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1111\/ddi.12469","article-title":"The Lost World\u2019s pristinity at risk","volume":"22","author":"Rull","year":"2016","journal-title":"Diversity and Distributions"},{"key":"2026103019465688500_vjag158-B49","doi-asserted-by":"publisher","first-page":"20130577","DOI":"10.1098\/rstb.2013.0577","article-title":"Risks of hormonally active pharmaceuticals to amphibians: A growing concern regarding progestagens","volume":"369","author":"S\u00e4fholm","year":"2014","journal-title":"Philosophical Transactions of the Royal Society of London: Series B, Biological Sciences"},{"key":"2026103019465688500_vjag158-B50","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1080\/14772000.2014.918061","article-title":"Establishing a baseline of plant diversity and endemism on a neotropical mountain summit for future comparative studies assessing upward migration: An approach from biogeography and nature conservation","volume":"12","author":"Safont","year":"2014","journal-title":"Systematics and Biodiversity"},{"key":"2026103019465688500_vjag158-B51","first-page":"157","volume-title":"South American herpetofauna: Its origin, evolution, and dispersal","author":"Simpson","year":"1979"},{"key":"2026103019465688500_vjag158-B52","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/s42003-020-01176-w","article-title":"Evolution of antibiotic resistance at low antibiotic concentrations including selection below the minimal selective concentration","volume":"3","author":"Stanton","year":"2020","journal-title":"Communications Biology"},{"key":"2026103019465688500_vjag158-B53","doi-asserted-by":"publisher","first-page":"127492","DOI":"10.1016\/j.jenvman.2025.127492","article-title":"Soil organic matter decomposition as a key driver of pharmaceutical retention","volume":"394","author":"Szab\u00f3","year":"2025","journal-title":"Journal of Environmental Management"},{"key":"2026103019465688500_vjag158-B54","volume-title":"Frontiers 2017\u2014Emerging issues of environmental concern","author":"United Nations Environment Programme","year":"2017"},{"key":"2026103019465688500_vjag158-B55","doi-asserted-by":"publisher","first-page":"168856","DOI":"10.1016\/j.scitotenv.2023.168856","article-title":"The occurrence of heavy metals and antimicrobials in sewage sludge and their predicted risk to soil\u2014Is there anything to fear?","volume":"912","author":"Urbaniak","year":"2024","journal-title":"Science of the Total Environment"},{"key":"2026103019465688500_vjag158-B56","author":"U.S. Environmental Protection Agency","year":"2003"},{"key":"2026103019465688500_vjag158-B57","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1002\/ieam.4560","article-title":"Default predicted no-effect target concentrations for antibiotics in the absence of data for the protection against antibiotic resistance and environmental toxicity","volume":"18","author":"Vestel","year":"2022","journal-title":"Integrated Environmental Assessment and Management"},{"key":"2026103019465688500_vjag158-B58","doi-asserted-by":"publisher","first-page":"107812","DOI":"10.1016\/j.envint.2023.107812","article-title":"Occurrence and the potential ecological risk of veterinary antimicrobials in swine farm wastewaters in Japan: Seasonal changes, relation to purchased quantity and after termination of oxytetracycline usage","volume":"173","author":"Watanabe","year":"2023","journal-title":"Environment International"},{"key":"2026103019465688500_vjag158-B59","doi-asserted-by":"publisher","first-page":"104244","DOI":"10.1016\/j.etap.2023.104244","article-title":"Veterinary pharmaceuticals and declining Cape Griffon Vulture (Gyps coprotheres) numbers: A potential threat to developing embryos","volume":"102","author":"Wiid","year":"2023","journal-title":"Environmental Toxicology and Pharmacology"},{"key":"2026103019465688500_vjag158-B60","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.mib.2010.08.005","article-title":"Antibiotic resistance in the environment: A link to the clinic?","volume":"13","author":"Wright","year":"2010","journal-title":"Current Opinion in Microbiology"},{"key":"2026103019465688500_vjag158-B61","doi-asserted-by":"publisher","first-page":"10436","DOI":"10.1007\/s11356-024-34544-8","article-title":"Occurrence of pharmaceutical residues in drinking water: A systematic review","volume":"32","author":"Zanni","year":"2025","journal-title":"Environmental Science and Pollution Research International"},{"key":"2026103019465688500_vjag158-B62","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1039\/C6EM00062B","article-title":"Occurrence, spatiotemporal distribution, mass balance and ecological risks of antibiotics in subtropical shallow Lake Taihu, China","volume":"18","author":"Zhou","year":"2016","journal-title":"Environmental Science: Processes & Impacts"}],"container-title":["Integrated Environmental Assessment and Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ieam\/advance-article-pdf\/doi\/10.1093\/inteam\/vjag158\/71671705\/vjag158.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ieam\/advance-article-pdf\/doi\/10.1093\/inteam\/vjag158\/71671705\/vjag158.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T23:47:05Z","timestamp":1793404025000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ieam\/advance-article\/doi\/10.1093\/inteam\/vjag158\/8876792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":62,"URL":"https:\/\/doi.org\/10.1093\/inteam\/vjag158","relation":{},"ISSN":["1551-3777","1551-3793"],"issn-type":[{"value":"1551-3777","type":"print"},{"value":"1551-3793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"article-number":"vjag158"}}