{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:16:27Z","timestamp":1790835387805,"version":"4.1.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"Supplement_3","license":[{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Stigma and poor mental health are important factors influencing the quality of life (QOL) of people with neglected tropical diseases (NTDs). This study examines the relationship between stigma, depression and QOL among people affected by leprosy and lymphatic filariasis (LF) in Nepal.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A cross-sectional community-based survey was conducted among 102 NTD-affected persons (70 leprosy and 32 LF) using interview-administered questionnaires measuring the level of stigma (5-QSI-AP), symptoms of depression (PHQ-9) and QOL (WHOQOL-8). Three different regression models were developed, each using the ordinary least squares and Poisson regression to evaluate the association between stigma and QOL, depression and QOL, and stigma and depression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mean scores were 21.8\u00b14.4 for QOL, 6.6\u00b15.6 for depression and 3.0\u00b12.8 for stigma. Almost 17% reported the prevalence of depression symptoms. Both stigma (\u03b2=\u22120.65, p&amp;lt;0.001) and depression (\u03b2=\u22120.32, p&amp;lt;0.001) were associated with lower scores for QOL, while there was a significant positive relationship between stigma and depression (\u03b2=0.92, p&amp;lt;0.001). Similar results were obtained from the Poisson regression models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The study showed a considerable burden of depression, stigma and poor QOL among study participants with leprosy and LF in Nepal. A holistic package of care that addresses the physical, mental and psychological well-being of people with NTD is required.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Contexte<\/jats:title>\n                  <jats:p>La stigmatisation et la mauvaise sant\u00e9 mentale sont des facteurs importants qui influencent la qualit\u00e9 de vie des personnes atteintes de maladies tropicales n\u00e9glig\u00e9es (MTN). Cette \u00e9tude examine la relation entre la stigmatisation, la d\u00e9pression et la qualit\u00e9 de vie chez les personnes atteintes de l\u00e8pre et de filariose lymphatique au N\u00e9pal.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>M\u00e9thodes utilis\u00e9es<\/jats:title>\n                  <jats:p>Une enqu\u00eate communautaire transversale a \u00e9t\u00e9 men\u00e9e aupr\u00e8s de 102 personnes atteintes de MTN (70 de la l\u00e8pre et 32 de la filariose lymphatique) \u00e0 l'aide de questionnaires administr\u00e9s par entretien mesurant le niveau de stigmatisation (5-QSI-AP), les sympt\u00f4mes de d\u00e9pression (PHQ-9) et la qualit\u00e9 de vie (WHOQOL-8). Trois mod\u00e8les de r\u00e9gression diff\u00e9rents ont \u00e9t\u00e9 d\u00e9velopp\u00e9s, chacun utilisant les moindres carr\u00e9s ordinaires et la r\u00e9gression de Poisson pour \u00e9valuer l'association entre : (i) la stigmatisation et la QV; (ii) la d\u00e9pression et la QV; et (iii) la stigmatisation et la d\u00e9pression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>R\u00e9sultats<\/jats:title>\n                  <jats:p>Les scores moyens \u00e9taient de 21,8\u00b14,4 pour la QV, 6,6\u00b15,6 pour la d\u00e9pression, et 3,0\u00b12,8 pour la stigmatisation. Pr\u00e8s de 17% des personnes interrog\u00e9es ont signal\u00e9 la pr\u00e9valence de sympt\u00f4mes d\u00e9pressifs. La stigmatisation (\u03b2 = \u22120,65, p&amp;lt;0\u00a0001) et la d\u00e9pression (\u03b2 = \u22120,32, p&amp;lt;0\u00a0001) ont \u00e9t\u00e9 associ\u00e9es \u00e0 des scores plus faibles pour la qualit\u00e9 de vie, tandis qu'il existait une relation positive significative entre la stigmatisation et la d\u00e9pression (\u03b2 = 0,92, p&amp;lt;0\u00a0001). Des r\u00e9sultats similaires ont \u00e9t\u00e9 obtenus \u00e0 partir des mod\u00e8les de r\u00e9gression de Poisson.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>L'\u00e9tude a montr\u00e9 une incidence importante de d\u00e9pression, de stigmatisation et d'une mauvaise qualit\u00e9 de vie parmi les participants atteints de l\u00e8pre et de FL au N\u00e9pal. Il convient donc de mettre en place un ensemble de soins holistiques pour ces patients qui prendrait en compte le bien-\u00eatre physique, mental et psychologique des personnes atteintes de MTN.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Antecedentes<\/jats:title>\n                  <jats:p>La estigmatizaci\u00f3n y la mala salud mental son factores importantes que influyen en la calidad de vida de las personas con enfermedades tropicales desatendidas. las personas con enfermedades tropicales desatendidas (ETD). Este estudio examina la relaci\u00f3n entre el estigma, la depresi\u00f3n y la CdV entre las personas afectadas por lepra y lepra y la filariasis linf\u00e1tica en Nepal.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>M\u00e9todos<\/jats:title>\n                  <jats:p>Se realiz\u00f3 una encuesta comunitaria transversal entre 102 personas afectadas por ETD (70 de lepra y 32 de filariasis linf\u00e1tica) utilizando cuestionarios entrevistas para medir el nivel de estigma (5-QSI-AP), los s\u00edntomas de depresi\u00f3n (PHQ- 9) y la CdV (OMS- 9). 9) y la calidad de vida (WHOQOL-8). Se desarrollaron tres modelos de regresi\u00f3n diferentes regresi\u00f3n de Poisson para evaluar la asociaci\u00f3n entre: (i) el estigma y (ii) la depresi\u00f3n. entre: (i) estigma y CdV; (ii) depresi\u00f3n y CdV; y (iii) estigma y depresi\u00f3n.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Resultados<\/jats:title>\n                  <jats:p>Las puntuaciones medias fueron 21,8\u00b14,4 para la CdV, 6,6\u00b15,6 para la depresi\u00f3n y 3,0\u00b12,8 para el estigma. Casi el 17% inform\u00f3 de la prevalencia de s\u00edntomas de depresi\u00f3n. Tanto el estigma (\u03b2 = \u22120,65, p&amp;lt;0\u00a0001), como la depresi\u00f3n (\u03b2 = \u22120,32, p&amp;lt;0\u00a0001) se asociaron con puntuaciones m\u00e1s bajas para la CdV, mientras que hubo una relaci\u00f3n positiva significativa entre el estigma y la depresi\u00f3n (\u03b2 = 0,92, p&amp;lt;0\u00a0001). Se obtuvieron resultados similares en los modelos de regresi\u00f3n de Poisson.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusiones<\/jats:title>\n                  <jats:p>El estudio mostr\u00f3 una carga considerable de depresi\u00f3n, estigma y mala CdV entre los participantes del estudio con lepra y FL en Nepal. Se requiere un paquete hol\u00edstico de atenci\u00f3n que aborde el bienestar f\u00edsico, mental y psicol\u00f3gico de las personas con ETD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/inthealth\/ihad099","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T20:51:07Z","timestamp":1703105467000},"page":"iii79-iii86","source":"Crossref","is-referenced-by-count":12,"title":["Stigma, depression and quality of life among people affected by neglected tropical diseases in Nepal"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5689-0837","authenticated-orcid":false,"given":"Deependra K","family":"Thapa","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Indiana University , Bloomington, IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsha R","family":"Dahal","sequence":"additional","affiliation":[{"name":"Nepal Public 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