{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:20:28Z","timestamp":1788337228891,"version":"build-2803163510"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,7]]},"DOI":"10.1093\/intimm\/12.7.1063","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T22:23:22Z","timestamp":1027722202000},"page":"1063-1074","source":"Crossref","is-referenced-by-count":51,"title":["Molecular evidence for antigen-driven immune responses in cardiac lesions of rheumatic heart disease patients"],"prefix":"10.1093","volume":"12","author":[{"given":"Luiza","family":"Guilherme","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Dulphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Douay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f4nica","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed\u00e9cio","family":"Cunha-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra E.","family":"Oshiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimunda V","family":"Assis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C.","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo M.","family":"Alberto Pomerantzeff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Charron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Toubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Kalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,7]]},"reference":[{"key":"key\n\t\t\t\t20170710084754_R1","doi-asserted-by":"crossref","unstructured":"Kaplan, M. H. and Suchy, M. L. 1964 Immunological relation of streptococcal and tissue antigens. II. Cross-reactions of antisera to mammalian heart tissue with a cell wall constituent of certain strains of group A streptococci. J. Exp. Med.119:643","DOI":"10.1084\/jem.119.4.643"},{"key":"key\n\t\t\t\t20170710084754_R2","doi-asserted-by":"crossref","unstructured":"Dale, J. B. and Beachey, E. H. 1985. Multiple, heart-cross-reactive epitopes of streptococcal M proteins. J. Exp. Med.161:113.","DOI":"10.1084\/jem.161.1.113"},{"key":"key\n\t\t\t\t20170710084754_R3","unstructured":"Zabriskie, J. B. 1986. Rheumatic fever: a model for the pathological consequences of microbial-host mimicry. Clin. Exp. Rheumatol.4:65"},{"key":"key\n\t\t\t\t20170710084754_R4","unstructured":"Gibofsky, A., Khanna, A., Suh, E. and Zabriskie, J. B. 1991. The genetics of rheumatic fever: relationship to streptococcal infection and autoimmune disease. J. Rheumatol.18 (suppl 30):1."},{"key":"key\n\t\t\t\t20170710084754_R5","doi-asserted-by":"crossref","unstructured":"Ayoub, E. M., Barrett, D. J., MacLaren, N. K. and Krischen, J. P. 1986. Association of class II histocompatibility leukocyte antigens with rheumatic fever. J. Clin. Invest.77:2019.","DOI":"10.1172\/JCI112531"},{"key":"key\n\t\t\t\t20170710084754_R6","doi-asserted-by":"crossref","unstructured":"Anastasiou-Nana, M., Anderson, J. L., Carquist, J. F. and Nanas, J. N. 1986. HLA DR typing and lymphocyte subset evaluation in rheumatic heart disease: a search for immune response factors. Am. Heart J.112:992.","DOI":"10.1016\/0002-8703(86)90311-X"},{"key":"key\n\t\t\t\t20170710084754_R7","doi-asserted-by":"crossref","unstructured":"Rajapakse, C. N. A., Halim, K., Al-Orainey, L., Al-Nozha, M. and Al-Aska, A. K. 1987. A genetic marker for rheumatic heart disease. Br. Heart J.58:659.","DOI":"10.1136\/hrt.58.6.659"},{"key":"key\n\t\t\t\t20170710084754_R8","doi-asserted-by":"crossref","unstructured":"Jhinghan, B., Mehra, N. K., Reddy, K. S., Taneja, V., Vaidya, M. C. and Bhatia, M. L. 1986. HLA, blood groups and secretor status in patients with established rheumatic fever and rheumatic heart disease. Tissue Antigens27:172.","DOI":"10.1111\/j.1399-0039.1986.tb01517.x"},{"key":"key\n\t\t\t\t20170710084754_R9","doi-asserted-by":"crossref","unstructured":"Guilherme, L., Weidebach, W., Kiss, M. H., Snitcowsky, R. and Kalil, J. 1991. Association of human leukocyte class II antigens with rheumatic fever or rheumatic heart disease in a Brazilian population. Circulation83:1995.","DOI":"10.1161\/01.CIR.83.6.1995"},{"key":"key\n\t\t\t\t20170710084754_R10","doi-asserted-by":"crossref","unstructured":"Weidebach, W., Goldberg, A. C., Chiarella, J., Guilherme, L., Snitcowsky, R., Pileggi, F. and Kalil, J. 1994. HLA class II antigens in rheumatic fever: analysis of the DR locus by RFLP and oligotyping. Hum. Immunol.40:253.","DOI":"10.1016\/0198-8859(94)90024-8"},{"key":"key\n\t\t\t\t20170710084754_R11","doi-asserted-by":"crossref","unstructured":"Maharaj, B., Hammond, M. G., Appadoo, B., Leary, W. P. and Pudifin, D. J. 1987. HLA-A, B, DR and DQ antigens in black patients with severe chronic rheumatic heart disease. Circulation76:259.","DOI":"10.1161\/01.CIR.76.2.259"},{"key":"key\n\t\t\t\t20170710084754_R12","doi-asserted-by":"crossref","unstructured":"Olmez, U., Turgay, M., Ozenirler, S., Tutkak, H., Duzgun, N., Duman, M. and Tokgoz, G. 1992. Association of HLA class I and class II antigens with rheumatic fever in a Turkish population. Rheumatology22:49.","DOI":"10.3109\/03009749309095114"},{"key":"key\n\t\t\t\t20170710084754_R13","doi-asserted-by":"crossref","unstructured":"Gu\u00e9dez, Y., Kotby, A., El-Demellawy, M., Galal, A., Thomson, G., Zaher, S., Kassem, S. and Kotb, M. 1999. HLA class II associations with rheumatic heart disease are more evident and consistent among clinically homogeneous patients. Circulation99:2784.","DOI":"10.1161\/01.CIR.99.21.2784"},{"key":"key\n\t\t\t\t20170710084754_R14","doi-asserted-by":"crossref","unstructured":"Stollerman, G. H. 1991. Rheumatogenic streptococci and autoimmunity. Clin. Immunol. Immunopathol.61:113.","DOI":"10.1016\/S0090-1229(05)80019-4"},{"key":"key\n\t\t\t\t20170710084754_R15","doi-asserted-by":"crossref","unstructured":"Smith, S. and Allen, P. 1992. Expression of myosin-class II major histocompatibility complexes in the normal myocardium occurs before induction of autoimmune myocarditis. Proc. Natl Acad. Sci. USA89:9131.","DOI":"10.1073\/pnas.89.19.9131"},{"key":"key\n\t\t\t\t20170710084754_R16","doi-asserted-by":"crossref","unstructured":"Chopra, P., Narula, J., Kumar, S. A., Sachdeva, S. and Bathia, M. L. 1988. Immunohistochemical characterization of Aschoff nodules and endomyocardial inflammatory infiltrates in left atrial appendages from patients with chronic rheumatic heart disease. Int. J. Cardiol.20:99.","DOI":"10.1016\/0167-5273(88)90319-1"},{"key":"key\n\t\t\t\t20170710084754_R17","doi-asserted-by":"crossref","unstructured":"Kemeny, E., Grieve, T., Marcus, R., Sareli, P. and Zabriskie, J. B. 1989. Identification of mononuclear cells and T cell subsets in rheumatic valvulitis. Clin. Immunol. Immunopathol.52:225.","DOI":"10.1016\/0090-1229(89)90174-8"},{"key":"key\n\t\t\t\t20170710084754_R18","doi-asserted-by":"crossref","unstructured":"Malkiel, S., Kuan, A. P. and Diamond, B. 1996. Autoimmunity in heart disease: mechanisms and genetic susceptibility. Mol. Med. Today2:337.","DOI":"10.1016\/1357-4310(96)81799-0"},{"key":"key\n\t\t\t\t20170710084754_R19","unstructured":"Penninger, J. M., Neu, N. and Bachmaier, K. 1996. A genetic map of autoimmune heart disease. The Immunologist4:131."},{"key":"key\n\t\t\t\t20170710084754_R20","unstructured":"Cunha-Neto, E. Guilherme, L., Goldberg, A. C. and Kalil, J. 2000. Molecular basis of post-infective autoimmune myocardial disorders. In Willerson, J. T., Virmani, R. and Narula, J., eds, Pathogenic Basis of Myocardial Diseases. Springer-Verlag, Berlin, in press."},{"key":"key\n\t\t\t\t20170710084754_R21","doi-asserted-by":"crossref","unstructured":"Marrack, P. and Kappler, J. 1990. The staphylococcal enterotoxins and their relatives. Science248:705.","DOI":"10.1126\/science.2185544"},{"key":"key\n\t\t\t\t20170710084754_R22","doi-asserted-by":"crossref","unstructured":"Achae-Orbea, H. and MacDonald, H. R. 1995. Superantigens of mouse mammary tumor virus. Annu. Rev. Immunol.13:459.","DOI":"10.1146\/annurev.iy.13.040195.002331"},{"key":"key\n\t\t\t\t20170710084754_R23","doi-asserted-by":"crossref","unstructured":"Hermann, E., Kapler, J. W., Marrack, P. and Pullen, A. M. 1991. Superantigens: mechanism of T-cell stimulation and role in immune responses. Annu. Rev. Immunol.9:745.","DOI":"10.1146\/annurev.iy.09.040191.003525"},{"key":"key\n\t\t\t\t20170710084754_R24","doi-asserted-by":"crossref","unstructured":"Schiffenbauer, J., Soos, J. and Johnson, H. 1998. The possible role of bacterial superantigens in the pathogenesis of autoimmune disorders. Immunol. Today19:117.","DOI":"10.1016\/S0167-5699(98)80009-1"},{"key":"key\n\t\t\t\t20170710084754_R25","doi-asserted-by":"crossref","unstructured":"Degnan, B., Taylor, J., Hawkes, C., O'Shea, U., Smith, J., Robinson, J. H., Kehoe, M. A., Boylston, A. and Goodacre, J. A. 1997. Streptococcus pyogenes type 5M protein is an antigen, not a superantigen, for human T cells. Hum. Immunol.53:206.","DOI":"10.1016\/S0198-8859(97)00028-1"},{"key":"key\n\t\t\t\t20170710084754_R26","doi-asserted-by":"crossref","unstructured":"Fleischer, B., Schmidt, K. H., Gerlach, D. and Kohler, W. 1992. Separation of T cell stimulating activity from streptococcal M protein. Infect. Immun.1767.","DOI":"10.1128\/IAI.60.5.1767-1770.1992"},{"key":"key\n\t\t\t\t20170710084754_R27","doi-asserted-by":"crossref","unstructured":"Li, P. L. L., Tiedemann, R. E., Moffat, L. S. and Fraser, J. D. 1997. The superantigen streptococcal pyrogenic exotoxin C (SPE-C) exhibits a novel mode of action. J. Exp. Med.186:375.","DOI":"10.1084\/jem.186.3.375"},{"key":"key\n\t\t\t\t20170710084754_R28","doi-asserted-by":"crossref","unstructured":"Maslanka, K., Piatek, T., Gorski, J., Yassai, M. and Gorski J. 1995. Molecular analysis of T cell repertoires. Spectratypes generated by multiplex polymerase chain reaction and evaluated by radioactivity of fluorescence. Hum. Immunol.44:28.","DOI":"10.1016\/0198-8859(95)00056-A"},{"key":"key\n\t\t\t\t20170710084754_R29","doi-asserted-by":"crossref","unstructured":"Pannetier, C., Cochet, M., Darche, S., Casrouge, A., Z\u00f6ller, M. and Kourilsky, P. 1993. The sizes of the CDR3 hypervariable regions of the murine T-cell receptor \u03b2 chains vary as a function of the recombined germline segments. Proc. Natl Acad. Sci. USA90:4319.","DOI":"10.1073\/pnas.90.9.4319"},{"key":"key\n\t\t\t\t20170710084754_R30","doi-asserted-by":"crossref","unstructured":"Even, J., Lim, A., Puisieux, I., Ferradine, L., Dietrich, P. Y., Toubert, A., Hercend, T., Triebel, F., Pannetier, C. and Kourilsky, P. 1995. T-cell repertoires in healthy and diseased human tissues analysed by T- cell receptor \u03b2-chain CDR3 size determination: evidence for oligoclonal expansions in tumors and inflammatory diseases. Res. Immunol.146:65.","DOI":"10.1016\/0923-2494(96)80240-9"},{"key":"key\n\t\t\t\t20170710084754_R31","doi-asserted-by":"crossref","unstructured":"Currier, J. R., Deulofeut, H., Barron, K. S., Kehn, P. J. and Robinson, M. A. 1996. Mitogens, superantigens, and nominal antigens elicit distinctive patterns of TCRB CDR3 diversity. Hum. Immunol.48:39.","DOI":"10.1016\/0198-8859(96)00076-6"},{"key":"key\n\t\t\t\t20170710084754_R32","doi-asserted-by":"crossref","unstructured":"Raizada, V., Williams, R. C., Jr, Chopra, P., Gopinath, N., Prakash, K., Sharma, K. B., Cherian, K. M., Panday, S., Arora, R., Nigam, M., Zabriskie, J. B. and Husby, G. 1983. Tissue distribution of lymphocytes in rheumatic heart valves as defined by monoclonal anti-T cells antibodies. Am. J. Med.74:225.","DOI":"10.1016\/0002-9343(83)91124-5"},{"key":"key\n\t\t\t\t20170710084754_R33","doi-asserted-by":"crossref","unstructured":"Guilherme, L., Cunha-Neto, E., Coelho, V., Snitcowsky, R., Pomerantzeff, P. M. A., Assis, R. V., Pedra, F., Neumann, J., Goldberg, A., Patarroyo, M. E., Pillegi, F. and Kalil, J. 1995. Human-infiltrating T cell clones from rheumatic heart disease patients recognize both streptococcal and cardiac proteins. Circulation92:415.","DOI":"10.1161\/01.CIR.92.3.415"},{"key":"key\n\t\t\t\t20170710084754_R34","doi-asserted-by":"crossref","unstructured":"Dajani, A. S., Ayoub, E., Bierman, F. Z., Bisno, A. L., Deny, F. W., Durack, D. T., Ferrieri, P., Freed, M., Gerber, M., Kaplan, E. L., Karchmer, A. W., Markowitz, M., Rahimtoola, S., Shulman, S., Stollerman, G., Takahashi, M., Taranta, A., Taubert, K. A. and Wilson, W. 1993. Guidelines for the diagnosis of rheumatic fever: Jones criteria, updated 1992. Circulation87:302.","DOI":"10.1161\/01.CIR.87.5.1776"},{"key":"key\n\t\t\t\t20170710084754_R35","doi-asserted-by":"crossref","unstructured":"Padula, S. J., Pollard, M. K., Lingenheld, E. G. and Clark, R. B. 1985. Maintenance of antigen specificity by human interleukin-2 dependent T cell lines. J. Clin. Invest.75:788.","DOI":"10.1172\/JCI111774"},{"key":"key\n\t\t\t\t20170710084754_R36","unstructured":"Weber, T., Kaufman, C., Zeevi, A., Zerbi, T. R., Hardesty, R. J., Kormos, R. H., Griffith, B. P. and Duquesnoy, R. J. 1989. Lymphocyte growth from cardiac allograft biopsy specimens with no or minimal cellular infiltrates: association with subsequent rejection episode. Heart Transplant.8:233."},{"key":"key\n\t\t\t\t20170710084754_R37","doi-asserted-by":"crossref","unstructured":"Olerup, O. and Zetterquist, H. 1992. HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: an alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation. Tissue Antigens39:225.","DOI":"10.1111\/j.1399-0039.1992.tb01940.x"},{"key":"key\n\t\t\t\t20170710084754_R38","doi-asserted-by":"crossref","unstructured":"Garderet, L., Dulphy, N., Douay, C., Chalumeau, N., Schaeffer, V., Zilber, M. T., Even, J., Mooney, N., Gelin, C., Gluckman, E., Charron, D. and Toubert, A. 1998. The umbilical cord blood \u03b1\u03b2 T-cell repertoire: characteristics of a polyclonal and naive but completely formed repertoire. Blood91:340.","DOI":"10.1182\/blood.V91.1.340.340_340_346"},{"key":"key\n\t\t\t\t20170710084754_R39","doi-asserted-by":"crossref","unstructured":"Pusieux, I., Even, J., Pannetier, C., Jotereau, F., Favrot, M. and Kourilsky, P. 1994. Oligoclonality of tumor-infiltranting lymphocytes from human melanomas. J. Immunol.153:2807.","DOI":"10.4049\/jimmunol.153.6.2807"},{"key":"key\n\t\t\t\t20170710084754_R40","doi-asserted-by":"crossref","unstructured":"Currier, J. R., Yassay, M., Robinson, M. A. and Gorski, J. 1996. Molecular defects in TCRBV gene preclude thymic selection and limit the expressed TCR repertoire. J. Immunol.157:170.","DOI":"10.4049\/jimmunol.157.1.170"},{"key":"key\n\t\t\t\t20170710084754_R41","doi-asserted-by":"crossref","unstructured":"Manjula, B. N., Acharya, A. S., Mische, M. S., Fairwell, T. and Fischetti, V. A. 1984. The complete amino acid sequence of a biologically active 197-residue fragment of M protein isolated from type 5 group A streptococci. J. Biol. Chem.259:3686.","DOI":"10.1016\/S0021-9258(17)43150-4"},{"key":"key\n\t\t\t\t20170710084754_R42","doi-asserted-by":"crossref","unstructured":"Phillips, G. N., Jr., Flicker, P. F., Cohen, C., Manjula, B. N. and Fischetti, V. A. 1981. Streptococcal M protein: alpha-helical coiled-coil structure and arrangement on the cell surface. Proc. Natl Acad. Sci. USA78:4689.","DOI":"10.1073\/pnas.78.8.4689"},{"key":"key\n\t\t\t\t20170710084754_R43","doi-asserted-by":"crossref","unstructured":"Houghten, R. A. 1985. General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino-acids. Proc. Natl Acad. Sci. USA82:5131.","DOI":"10.1073\/pnas.82.15.5131"},{"key":"key\n\t\t\t\t20170710084754_R44","doi-asserted-by":"crossref","unstructured":"Abou-Zeid, C., Filley, E., Steele, J. and Rook, G. A. W. 1987. A simple new method for using antigens separated by polyacrylamide gel electrophoresis to stimulate lymphocytes `in vitro' after converting bands cut from Western blots into antigen-bearing particles. J. Immunol. Methods98:5.","DOI":"10.1016\/0022-1759(87)90429-7"},{"key":"key\n\t\t\t\t20170710084754_R45","doi-asserted-by":"crossref","unstructured":"Margossian, S. and Lowey, S. 1982. Preparation of myosin and its subfragments from rabbit skeletal muscle. Methods Enzymol.85:55.","DOI":"10.1016\/0076-6879(82)85009-X"},{"key":"key\n\t\t\t\t20170710084754_R46","doi-asserted-by":"crossref","unstructured":"Dulphy, N., Peyrat, M. A, Tieng, V., Douay, C., Rabian, C., Tamouza, R., Laoussadi, S., Berenbaum, F., Chabot, A., Bonneville, M., Charron, D. and Toubert, A. 1999. Common intra-articular T cell expressions in patients with reactive arthritis: identical \u03b2-chain junctional sequences and cytotoxicity toward HLA-B27. J. Immunol.162:3830.","DOI":"10.4049\/jimmunol.162.7.3830"},{"key":"key\n\t\t\t\t20170710084754_R47","doi-asserted-by":"crossref","unstructured":"Kotb, M., Majumdar, G., Tomai, M. and Beachey, E. H. 1990. Accessory cell-independent stimulation of human T cells by streptococcal M protein superantigen. J Immunol.145:1332.","DOI":"10.4049\/jimmunol.145.5.1332"},{"key":"key\n\t\t\t\t20170710084754_R48","doi-asserted-by":"crossref","unstructured":"Tomai, M., Kotb, M., Majumdar, G. and Beachey, E. H. 1990. Superantigenicity of streptococcal M protein. J. Exp. Med.172:359.","DOI":"10.1084\/jem.172.1.359"},{"key":"key\n\t\t\t\t20170710084754_R49","doi-asserted-by":"crossref","unstructured":"Tomai, M. A., Schlievert, P. M. and Kotb, M. 1992. Distinct T-cell receptor V\u03b2 gene usage by human T lymphocytes stimulated with the streptococcal pyrogenic exotoxins and pep M5 protein. Infect. Immun.60:701.","DOI":"10.1128\/IAI.60.2.701-705.1992"},{"key":"key\n\t\t\t\t20170710084754_R50","doi-asserted-by":"crossref","unstructured":"Watanabe-Ohnishi, R., Aelion, J., Legros, L., Tomai, M. A., Sokurenko, E. V., Newton, D., Takahara, J., Irino, S., Rashed, S. and Kotb, M. 1994. Characterization of unique human TCR V\u03b2 specificities for a family of streptococcal superantigens represented by rheumatogenic serotypes of M protein. J. Immunol.152:2066.","DOI":"10.4049\/jimmunol.152.4.2066"},{"key":"key\n\t\t\t\t20170710084754_R51","doi-asserted-by":"crossref","unstructured":"Tomai, M. A., Aelion, J., Dockter, M. E., Majumdar, G., Spinella, D. G. and Kotb, M. 1991. T cell receptor V\u03b2 gene usage by human T cells stimulated with the superantigen streptococcal M protein. J. Exp. Med.174:285.","DOI":"10.1084\/jem.174.1.285"},{"key":"key\n\t\t\t\t20170710084754_R52","doi-asserted-by":"crossref","unstructured":"Wang, B., Schlievert, P. M., Gaber, A. O. and Kotb, M. 1993. Localization of an immunologically functional region of the streptococcal superantigen pepsin-extracted fragment of type 5 M protein. J. Immunol.151:1419.","DOI":"10.4049\/jimmunol.151.3.1419"},{"key":"key\n\t\t\t\t20170710084754_R53","doi-asserted-by":"crossref","unstructured":"Steinman, L., Oksenberg, J. R. and Bernard, C. C. A. 1992. Association of susceptibility to multiple sclerosis with TCR genes. Immunol. Today.13:49.","DOI":"10.1016\/0167-5699(92)90133-R"},{"key":"key\n\t\t\t\t20170710084754_R54","doi-asserted-by":"crossref","unstructured":"Behar S. M. and Porcelli S. A. 1995. Mechanisms of autoimmune disease induction. The role of the immune response of the microbial pathogens. Arthritis Rheum.4:458.","DOI":"10.1002\/art.1780380403"},{"key":"key\n\t\t\t\t20170710084754_R55","doi-asserted-by":"crossref","unstructured":"Conrad, B., Weldmann, E., Trucco, G., Rudert, W. A., Behboo, R., Ricordi, C., Rodriguez-Rilo, H., Finegold D. and Trucco, M. 1994. Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology. Nature371:351.","DOI":"10.1038\/371351a0"},{"key":"key\n\t\t\t\t20170710084754_R56","doi-asserted-by":"crossref","unstructured":"Gigliotti, D., Lefvert, A. K., Jeddi-Tehrani, M., Esin, S., Hodara, V., Pirskanen, R., Wigzell, H. and Andersson, R. 1996. Overexpression of select T cell receptor V\u03b2 gene families within CD4+ and CD8+ T cell subsets of myasthenia gravis patients: a role for superantigen(s)? Mol. Med.2:452.","DOI":"10.1007\/BF03401904"},{"key":"key\n\t\t\t\t20170710084754_R57","doi-asserted-by":"crossref","unstructured":"Dietrich, P. Y., Walker, P. R., Chnuriger, V., Saas, P., Perrin, G., Guilard, M., Gaudin, C. and Caignard, A. 1997. TCR analysis reveals significant repertoire selection during in vitro lymphocyte culture. Int. Immunol.9:1073.","DOI":"10.1093\/intimm\/9.8.1073"},{"key":"key\n\t\t\t\t20170710084754_R58","doi-asserted-by":"crossref","unstructured":"Garcia, K. G., Teyton, L. and Wilson, I. A. 1999. Structural basis of T cell recognition. Annu. Rev. Immunol.17:369.","DOI":"10.1146\/annurev.immunol.17.1.369"},{"key":"key\n\t\t\t\t20170710084754_R59","doi-asserted-by":"crossref","unstructured":"Oksenberg, J. R., Panzarra, M. A., Begovich, A. B., Mitchell, D., Erlich, H. A., Murray, R. S., Shimonkevitz, R., Sherrit, M., Rothbard, J., Bernard, C. C. A. and Steinman, L. 1993. Selection for T-cell receptor V\u03b2\u2013D\u03b2\u2013J\u03b2 gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis. Nature362:69.","DOI":"10.1038\/362068a0"},{"key":"key\n\t\t\t\t20170710084754_R60","doi-asserted-by":"crossref","unstructured":"Lim, A., Toubert, A., Pannetier, C., Dougados, M., Charron, D., Kourilsky, P. and Even, J. 1996. Spread of clonal T-cell expansions in rheumatoid arthritis patients. Hum. Immunol.48:77.","DOI":"10.1016\/0198-8859(96)00089-4"},{"key":"key\n\t\t\t\t20170710084754_R61","doi-asserted-by":"crossref","unstructured":"Cunningham, M. W., Antone, S. M., Smart, M., Liu, R. and Kosanke, S. 1997. Molecular analysis of human cardiac myosin-cross-reactive B and T-cell epitopes of the group A streptococcal M5 protein. Infect. Immun.65:3913.","DOI":"10.1128\/IAI.65.9.3913-3923.1997"},{"key":"key\n\t\t\t\t20170710084754_R62","doi-asserted-by":"crossref","unstructured":"Dale, J. B. and Beachey, E. H. 1992. Protective antigenic determinant of streptococcal M protein shared with sarcolemmal membrane protein of human heart. J. Exp. Med.156:1165.","DOI":"10.1084\/jem.156.4.1165"},{"key":"key\n\t\t\t\t20170710084754_R63","doi-asserted-by":"crossref","unstructured":"Dale, J. B. and Beachey E. H. . 1985. Epitopes of streptococcal M proteins shared with cardiac myosin. J. Exp. Med.162:583.","DOI":"10.1084\/jem.162.2.583"},{"key":"key\n\t\t\t\t20170710084754_R64","doi-asserted-by":"crossref","unstructured":"Cunningham, M. W., McCormack, J. M., Fenderson, P. G., Beachey, E. H., Dale, J. B. 1989. Human and murine antibodies cross-reactive with streptococcal M protein and myosin recognize the sequence GLN-LYS-SER-LYS-GLN in M protein. J. Immunol.143:2677.","DOI":"10.4049\/jimmunol.143.8.2677"},{"key":"key\n\t\t\t\t20170710084754_R65","doi-asserted-by":"crossref","unstructured":"Cunningham, M. W., McCormack, J. M., Talaber, L. R., Harley, J. B., Ayoub, E. M., Muneer, R. S., Chun, L. T. and Reddy, L. V. 1988. Human monoclonal antibodies reactive with antigens of the group A streptococcus and human heart. J. Immunol.14:2760.","DOI":"10.4049\/jimmunol.141.8.2760"},{"key":"key\n\t\t\t\t20170710084754_R66","doi-asserted-by":"crossref","unstructured":"Bach, J. F., Chalons, S., Forier, E., Elana, G., Jouanelle, J., Kayemba, S., Delbois, D., Mosser, A., Saint-Aime, C. and Berchel, C. 1996. 10-year educational programme aimed at rheumatic fever in two French Caribbean islands. Lancet347:644.","DOI":"10.1016\/S0140-6736(96)91202-7"}],"container-title":["International Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/intimm\/article-pdf\/12\/7\/1063\/18319935\/1063.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T03:34:49Z","timestamp":1682220889000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/intimm\/article-lookup\/doi\/10.1093\/intimm\/12.7.1063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":66,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2000,7]]},"published-print":{"date-parts":[[2000,7]]}},"URL":"https:\/\/doi.org\/10.1093\/intimm\/12.7.1063","relation":{},"ISSN":["1460-2377","0953-8178"],"issn-type":[{"value":"1460-2377","type":"electronic"},{"value":"0953-8178","type":"print"}],"subject":[],"published":{"date-parts":[[2000,7]]}}}