{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:46:30Z","timestamp":1773211590360,"version":"3.50.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,3]]},"DOI":"10.1093\/intimm\/13.3.297","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T22:50:44Z","timestamp":1027723844000},"page":"297-304","source":"Crossref","is-referenced-by-count":44,"title":["IL-4 gene expression up-regulated by mercury in rat mast cells: a role of oxidant stress in IL-4 transcription"],"prefix":"10.1093","volume":"13","author":[{"given":"Zhonglin","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B. G.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,3]]},"reference":[{"key":"key\n\t\t\t\t20170710112238_R1","doi-asserted-by":"crossref","unstructured":"Mosmann, T. R. and Sad, S. 1996. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today17:138.","DOI":"10.1016\/0167-5699(96)80606-2"},{"key":"key\n\t\t\t\t20170710112238_R2","doi-asserted-by":"crossref","unstructured":"Abbas, A. K., Murphy, K. M. and Sher, A. 1996. Functional diversity of helper T lymphocytes. Nature383:787.","DOI":"10.1038\/383787a0"},{"key":"key\n\t\t\t\t20170710112238_R3","doi-asserted-by":"crossref","unstructured":"Morel, P. A. and Oriss, T. B. 1998 Crossregulation between Th1 and Th2 cells. Crit. Rev. Immunol.18:275.","DOI":"10.1615\/CritRevImmunol.v18.i4.10"},{"key":"key\n\t\t\t\t20170710112238_R4","doi-asserted-by":"crossref","unstructured":"Swain, S. L., Weinberg, A. D., English, M. and Huston, G. 1990. IL-4 directs the development of Th2-like helper effectors. J. Immunol.145:3796.","DOI":"10.4049\/jimmunol.145.11.3796"},{"key":"key\n\t\t\t\t20170710112238_R5","doi-asserted-by":"crossref","unstructured":"Yoshimoto, T. and Paul, W. E. 1994. CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med.179:1285.","DOI":"10.1084\/jem.179.4.1285"},{"key":"key\n\t\t\t\t20170710112238_R6","doi-asserted-by":"crossref","unstructured":"Plaut, M., Pierce, J. H., Watson, C. J., Hanley-Hyde, J., Nordan, R. P. and Paul, W. E. 1989. Mast cell lines produce lymphokines in response to cross-linkage of Fc\u03b5R1 or to calcium ionophores. Nature339:64.","DOI":"10.1038\/339064a0"},{"key":"key\n\t\t\t\t20170710112238_R7","doi-asserted-by":"crossref","unstructured":"Schmitz, J., Thiel, A., K\u00fchn, R., Rajewsky, K., M\u00fcller, W., Assenmacher, M. and Radbruch, A. 1994. Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells. J. Exp. Med.179:1349.","DOI":"10.1084\/jem.179.4.1349"},{"key":"key\n\t\t\t\t20170710112238_R8","doi-asserted-by":"crossref","unstructured":"Oliveira, D. B. G., Gillespie, K. M., Wolfreys, K., Mathieson, P. W., Qasim, F. and Coleman, J. W. 1995. Compounds that induce autoimmunity in the Brown Norway rat sensitize mast cells for mediator release and IL-4 expression. Eur. J. Immunol.25:2259.","DOI":"10.1002\/eji.1830250822"},{"key":"key\n\t\t\t\t20170710112238_R9","doi-asserted-by":"crossref","unstructured":"Wolfreys, K. and Oliveira, D. B. G. 1997. Alterations in intracellular reactive oxygen species generation and redox potential modulate mast cell function. Eur. J. Immunol.27:297.","DOI":"10.1002\/eji.1830270143"},{"key":"key\n\t\t\t\t20170710112238_R10","doi-asserted-by":"crossref","unstructured":"Kiely, P. D. W., Pecht, I. and Oliveira, D. B. G. 1997. Mercuric chloride-induced vasculitis in the Brown Norway rat: \u03b1\u03b2 T cell dependent and independent phases\u2014role of the mast cell. J. Immunol.159:5100.","DOI":"10.4049\/jimmunol.159.10.5100"},{"key":"key\n\t\t\t\t20170710112238_R11","unstructured":"Sapin, C., Druet, E. and Druet, P. 1977. Induction of anti-glomerular basement membrane antibodies in the Brown-Norway rat by mercuric chloride. Clin. Exp. Immunol.28:173."},{"key":"key\n\t\t\t\t20170710112238_R12","doi-asserted-by":"crossref","unstructured":"Pusey, C. D., Bowman, C., Morgan, A., Weetman, A. P., Hartley, B. and Lockwood, C. M. 1990. Kinetics and pathogenicity of autoantibodies induced by mercuric chloride in the Brown Norway rat. Clin. Exp. Immunol.81:76.","DOI":"10.1111\/j.1365-2249.1990.tb05294.x"},{"key":"key\n\t\t\t\t20170710112238_R13","unstructured":"Esnault, V. L. M., Mathieson, P. W., Thiru, S., Oliveira, D. B. G. and Lockwood, C. M. 1992. Autoantibodies to myeloperoxidase in Brown Norway rats treated with mercuric chloride. Lab. Invest.67:114."},{"key":"key\n\t\t\t\t20170710112238_R14","unstructured":"Mathieson, P. W., Thiru, S. and Oliveira, D. B. G. 1992. Mercuric chloride-treated Brown Norway rats develop widespread tissue injury including necrotizing vasculitis. Lab. Invest.67:121."},{"key":"key\n\t\t\t\t20170710112238_R15","unstructured":"Kiely, P. D. W., Thiru, S. and Oliveira, D. B. G. 1995. Inflammatory polyarthritis induced by mercuric chloride in the Brown Norway rat. Lab. Invest.73:284."},{"key":"key\n\t\t\t\t20170710112238_R16","doi-asserted-by":"crossref","unstructured":"Prouvost-Danon, A., Abadie, A., Sapin, C., Bazin, H. and Druet, P. 1981 Induction of IgE synthesis and potentiation of anti-ovalbumin IgE antibody response by HgCl2 in the rat. J. Immunol.126:699.","DOI":"10.4049\/jimmunol.126.2.699"},{"key":"key\n\t\t\t\t20170710112238_R17","unstructured":"Pelletier, L., Pasquier, R., Vial, M., Mandet, C., Moutier, R., Salomon, J. C. and Druet, P. 1987. Mercury-induced autoimmune glomerulonephritis: requirement for T cells. Nephrol. Dial. Transplant.1:211."},{"key":"key\n\t\t\t\t20170710112238_R18","doi-asserted-by":"crossref","unstructured":"Pelletier, L., Pasquier, R., Rossert, J., Vial, M., Mandet, C. and Druet, P. 1988. Autoreactive T cells in mercury-induced autoimmunity: ability to induce the autoimmune disease. J. Immunol.140:750.","DOI":"10.4049\/jimmunol.140.3.750"},{"key":"key\n\t\t\t\t20170710112238_R19","doi-asserted-by":"crossref","unstructured":"Finkelman, F. D., Katona, I. M., Urban, J. F., Holmes, J., Ohara, J., Tung, A. S., Sample, J. v. and Paul, W. E. 1988. IL-4 is required to generate and sustain in vivo IgE responses. J. Immunol.141:2335.","DOI":"10.4049\/jimmunol.141.7.2335"},{"key":"key\n\t\t\t\t20170710112238_R20","doi-asserted-by":"crossref","unstructured":"Mathieson, P. W., Thiru, S. and Oliveira, D. B. G. 1993. Regulatory role of OX22+ T cells in mercury-induced autoimmunity in the Brown Norway rat. J. Exp. Med.177:1309.","DOI":"10.1084\/jem.177.5.1309"},{"key":"key\n\t\t\t\t20170710112238_R21","doi-asserted-by":"crossref","unstructured":"Ochel, M., Vohr, H. W., Pfeiffer, C. and Gleichmann, E. 1991. IL4 is required for the IgE and IgG1 increase and IgG1 autoantibody formation in mice treated with mercuric chloride. J. Immunol.146:3006.","DOI":"10.4049\/jimmunol.146.9.3006"},{"key":"key\n\t\t\t\t20170710112238_R22","doi-asserted-by":"crossref","unstructured":"Gillespie, K. M., Qasim, F. J., Tibbatts, L. M., Thiru, S., Oliveira, D. B. G. and Mathieson, P. W. 1995. Interleukin-4 gene expression in mercury-induced autoimmunity. Scand. J. Immunol.41:268.","DOI":"10.1111\/j.1365-3083.1995.tb03563.x"},{"key":"key\n\t\t\t\t20170710112238_R23","doi-asserted-by":"crossref","unstructured":"Qasim, F. J., Mathieson, P. W., Thiru, S. and Oliveira, D. B. G. 1995. Time course and characterisation of mercuric chloride induced autoimmunity in the Brown Norway rat. J. Autoimmunity8:195.","DOI":"10.1006\/jaut.1995.0015"},{"key":"key\n\t\t\t\t20170710112238_R24","doi-asserted-by":"crossref","unstructured":"Chomczynski, P. and Sacchi, N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate\u2013phenol\u2013chloroform extraction. Anal. Biochem.162:156.","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"key\n\t\t\t\t20170710112238_R25","doi-asserted-by":"crossref","unstructured":"Didcock, L., Young, D. F., Goodbourn, S. and Randall, R. E. 1999. Sendai virus and simian virus 5 block activation of interferon-responsive genes: importance for virus pathogenesis. J. Virol.73:3125.","DOI":"10.1128\/JVI.73.4.3125-3133.1999"},{"key":"key\n\t\t\t\t20170710112238_R26","doi-asserted-by":"crossref","unstructured":"Badou, A., Savignac, M., Moreau, M., Leclerc, C., Pasquier, R., Druet, P. and Pelletier, L. 1997. HgCl2-induced interleukin-4 gene expression in T cells involves a protein kinase C-dependent calcium influx through L-type calcium channels. J. Biol. Chem.272:32411.","DOI":"10.1074\/jbc.272.51.32411"},{"key":"key\n\t\t\t\t20170710112238_R27","doi-asserted-by":"crossref","unstructured":"Jeannin, P., Delneste, Y., Lecoanet-Henchoz, S., Gauchat, J.-F., Life, P., Holmes, D. and Bonnefoy, J.-Y. 1995. Thiols decrease human interleukin (IL) 4 production and IL-4-induced immunoglobulin synthesis. J. Exp. Med.182:1785.","DOI":"10.1084\/jem.182.6.1785"},{"key":"key\n\t\t\t\t20170710112238_R28","doi-asserted-by":"crossref","unstructured":"Prigent, P., Saoudi, A., Pannetier, C., Graber, P., Bonnefoy, J., Druet, P. and Hirsch, F. 1995. Mercuric chloride, a chemical responsible for T helper cell (Th) 2-mediated autoimmunity in Brown Norway rats, directly triggers T cells to produce interleukin-4. J. Clin. Invest.96:1484.","DOI":"10.1172\/JCI118185"},{"key":"key\n\t\t\t\t20170710112238_R29","doi-asserted-by":"crossref","unstructured":"Salahudeen, A. K., Clark, E. C. and Nath, K. A. 1991. Hydrogen peroxide-induced renal injury: a protective role for pyruvate in vitro and in vivo. J. Clin. Invest.88:1886.","DOI":"10.1172\/JCI115511"},{"key":"key\n\t\t\t\t20170710112238_R30","doi-asserted-by":"crossref","unstructured":"Ames, B. N., Shigenaga, M. K. and Hagen, T. M. 1993. Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl Acad. Sci. USA90:7915.","DOI":"10.1073\/pnas.90.17.7915"},{"key":"key\n\t\t\t\t20170710112238_R31","doi-asserted-by":"crossref","unstructured":"Bagchi, N., Brown, T. R., Herdegen, D. M., Dhar, A. and Sundick, R. S. 1990. Antioxidants delay the onset of thyroiditis in obese strain chickens. Endocrinology127:1590.","DOI":"10.1210\/endo-127-4-1590"},{"key":"key\n\t\t\t\t20170710112238_R32","doi-asserted-by":"crossref","unstructured":"Barnes, P. J. 1990. Reactive oxygen species and airway inflammation. Free Rad. Biol. Med.9:235.","DOI":"10.1016\/0891-5849(90)90034-G"},{"key":"key\n\t\t\t\t20170710112238_R33","doi-asserted-by":"crossref","unstructured":"Djukanovic, R., Roche, W. R., Wilson, J. W., Beasley, C. R. W., Twentyman, O. P., Howarth, P. H. and Holgate, S. T. 1990. Mucosal inflammation in asthma. Am. Rev. Respir. Dis.14:434.","DOI":"10.1164\/ajrccm\/142.2.434"},{"key":"key\n\t\t\t\t20170710112238_R34","doi-asserted-by":"crossref","unstructured":"Ohmori, H., Komoriya, K., Azuma, A., Kurozumi, S. and Hashimoto, Y. 1979. Xanthine oxidase-induced histamine release from isolated rat peritoneal mast cells: involvement of H2O2. Biochem. Pharmacol.28:333.","DOI":"10.1016\/0006-2952(79)90524-0"},{"key":"key\n\t\t\t\t20170710112238_R35","doi-asserted-by":"crossref","unstructured":"Hussain, S., Rodgers, D. A., Duhart, H. M. and Ali, S. F. 1998. Mercuric chloride-induced reactive oxygen species and its effect on antioxidant enzymes in different regions of rat brain. J. Environ. Sci. Health B32:395.","DOI":"10.1080\/03601239709373094"},{"key":"key\n\t\t\t\t20170710112238_R36","doi-asserted-by":"crossref","unstructured":"Peden, D. B., Dailey, L., DeGraff, W., Mitchell, J. B., Lee, J. G., Kaliner, M. A. and Hohman, R. J. 1994. Hydrogen peroxide effects on rat mast cell function. Am. J. Physiol.267:L85.","DOI":"10.1152\/ajplung.1994.267.1.L85"},{"key":"key\n\t\t\t\t20170710112238_R37","doi-asserted-by":"crossref","unstructured":"Liang, S.-M., Lee, N., Finbloom, D. S. and Liang, C.-M. 1992. Regulation by glutanthione of interleukin-4 activity on cytotoxic T cells. Immunology75:435.","DOI":"10.1016\/0008-8749(92)90231-D"},{"key":"key\n\t\t\t\t20170710112238_R38","doi-asserted-by":"crossref","unstructured":"Sandstrom, P. A., Mannie, M. D. and Buttke, T. M. 1994. Inhibition of activation-induced death in T cell hybridomas by thiol antioxidants: oxidative stress as a mediator of apoptosis. J. Leuk. Biol.55:221.","DOI":"10.1002\/jlb.55.2.221"},{"key":"key\n\t\t\t\t20170710112238_R39","doi-asserted-by":"crossref","unstructured":"Yim, C.-Y., Hibbs, J. B. J., McGregor, J. R., Galinsky, R. E. and Samlowski, W. E. 1994. Use of N-acetyl cysteine to increase intracellular glutathione during the induction of antitumor responses by IL-2. J. Immunol.152:5796.","DOI":"10.4049\/jimmunol.152.12.5796"},{"key":"key\n\t\t\t\t20170710112238_R40","doi-asserted-by":"crossref","unstructured":"Klebanoff, S. J. 1982. The iron\u2013H2O2\u2013iodide cytotoxic system. J. Exp. Med.156:1262.","DOI":"10.1084\/jem.156.4.1262"},{"key":"key\n\t\t\t\t20170710112238_R41","doi-asserted-by":"crossref","unstructured":"Schreck, R., Rieber, P. and Baeuerle, P. A. 1991. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J.10:2247.","DOI":"10.1002\/j.1460-2075.1991.tb07761.x"},{"key":"key\n\t\t\t\t20170710112238_R42","doi-asserted-by":"crossref","unstructured":"Schreck, R., Albermann, K. and Baeuerle, P. A. 1992. Nuclear factor kappa beta: an oxidative stress-responsive transcription factor of eukaryotic cells. Free Rad. Res. Commun.17:221.","DOI":"10.3109\/10715769209079515"},{"key":"key\n\t\t\t\t20170710112238_R43","doi-asserted-by":"crossref","unstructured":"Kikumori, T., Kambe, F., Nagaya, T., Imai, T., Funahashi, H. and Seo, H. 1998. Activation of transcriptionally active nuclear factor-kB by tumor necrosis factor-\u03b1 and its inhibition by antioxidants in rat thyroid FRTL-5 cells. Endocrinology139:1715.","DOI":"10.1210\/endo.139.4.5874"},{"key":"key\n\t\t\t\t20170710112238_R44","doi-asserted-by":"crossref","unstructured":"Brown, M. A. and Hural, J. 1997. Functions of IL-4 and control of its expression. Crit. Rev. Immunol.17:1.","DOI":"10.1615\/CritRevImmunol.v17.i1.10"},{"key":"key\n\t\t\t\t20170710112238_R45","doi-asserted-by":"crossref","unstructured":"Yanagihara, Y., Basaki, Y., Ikizawa, K. and Kajiwara, K. 1997. Possible role of nuclear factor-\u03baB activity in germline C\u03b5 transcription in a human Burkitt lymphoma B cell line. Cell. Immunol.176:66.","DOI":"10.1006\/cimm.1996.1071"},{"key":"key\n\t\t\t\t20170710112238_R46","unstructured":"Pollard, K. M. and Hultman, P. 1997. Effects of Mercury on the Immune System. In Sigel, A. and Sigel, H., eds, Metal Ions in Biological Systems, p. 421. Marcel Dekker, New York."}],"container-title":["International Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/intimm\/article-pdf\/13\/3\/297\/18403152\/130297.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T04:39:40Z","timestamp":1682224780000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/intimm\/article-lookup\/doi\/10.1093\/intimm\/13.3.297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3]]},"references-count":46,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2001,3]]},"published-print":{"date-parts":[[2001,3]]}},"URL":"https:\/\/doi.org\/10.1093\/intimm\/13.3.297","relation":{},"ISSN":["0953-8178","1460-2377"],"issn-type":[{"value":"0953-8178","type":"print"},{"value":"1460-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,3]]}}}