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Interestingly, vascular permeability of the thymic cortex is lower than in other organs, suggesting the existence of a blood\u2013thymus barrier (BTB). On the other hand, blood-borne molecules and dendritic cells bearing self-antigens are accessible to the medulla, facilitating central tolerance induction, and continuous T-precursor immigration and mature thymocyte egress occur through the vessels at the cortico-medullary junction (CMJ). We found that claudin-5 (Cld5), a membrane protein of tight junctions, was expressed in essentially all ECs of the cortical vasculatures, whereas approximately half of the ECs of the medulla and CMJ lacked Cld5 expression. An intravenously (i.v.) injected biotin tracer hardly penetrated cortical Cld5+ vessels, but it leaked into the medullary parenchyma through Cld5\u2013 vessels. Cld5 expression in an EC cell line caused a remarkable increase in trans-endothelial resistance in vitro, and the biotin tracer leaked from the cortical vasculatures in Cldn5\u2013\/\u2013 mice. Furthermore, i.v.-injected sphingosine-1 phosphate distributed selectively into the medulla through the Cld5\u2013 vessels, probably ensuring the egress of CD3high mature thymocytes from Cld5\u2013 vessels at the CMJ. These results suggest that distinct Cld5 expression profiles in the cortex and medulla may control the BTB and the T-cell gateway to blood circulation, respectively.<\/jats:p>","DOI":"10.1093\/intimm\/dxaa069","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T19:24:10Z","timestamp":1602185050000},"page":"171-182","source":"Crossref","is-referenced-by-count":25,"title":["Selective expression of claudin-5 in thymic endothelial cells regulates the blood\u2013thymus barrier and T-cell export"],"prefix":"10.1093","volume":"33","author":[{"given":"Takahiro","family":"Nagatake","sequence":"first","affiliation":[{"name":"Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University , Kyoto, Japan"},{"name":"Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN) , Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Chun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Graduate School of Biostudies, Kyoto University , Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University , Kyoto, Japan"},{"name":"Laboratory of Immunobiology, Graduate School of Medicine, Center for iPS Cell Research and Application (CiRA), Kyoto University , Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine, Dokkyo Medical University , Tochigi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Kometani","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology, Graduate School of Medicine, Center for iPS Cell Research and Application (CiRA), Kyoto University , Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikio","family":"Furuse","sequence":"additional","affiliation":[{"name":"Division of Cell Structure, National Institute for Physiological Sciences , Okazaki, Aichi, Japan"},{"name":"Department of Physiological Sciences, SOKENDAI, The Graduate University for Advanced Studies , Okazaki, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azusa","family":"Saika","sequence":"additional","affiliation":[{"name":"Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN) , Osaka, Japan"},{"name":"Graduate School of Pharmaceutical Sciences, Osaka University , Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Node","sequence":"additional","affiliation":[{"name":"Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN) , Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kunisawa","sequence":"additional","affiliation":[{"name":"Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN) , Osaka, Japan"},{"name":"Graduate School of Pharmaceutical Sciences, Osaka University , Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagahiro","family":"Minato","sequence":"additional","affiliation":[{"name":"Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University , Kyoto, Japan"},{"name":"Graduate School of Biostudies, Kyoto University , Kyoto, Japan"},{"name":"Medical Innovation Center, Kyoto University , Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Hamazaki","sequence":"additional","affiliation":[{"name":"Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University , Kyoto, Japan"},{"name":"Laboratory of Immunobiology, Graduate School of Medicine, Center for iPS Cell Research and Application (CiRA), Kyoto University , Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,10,10]]},"reference":[{"key":"2023120103420330400_CIT0001","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1146\/annurev-immunol-051116-052320","article-title":"Thymic epithelial cells","volume":"35","author":"Abramson","year":"2017","journal-title":"Annu. 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