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An abundance of neutrophils is seen in the inflammatory lesions, but adaptive immunity is also an important player in the chronicity of the disease. There is an unmet need for new treatment options since modern medicines such as biological therapy with anti-cytokine antibodies still leave a substantial number of patients with persisting disease activity. The role of the central nervous system and its interaction with the gut in the pathophysiology of IBD have been brought to attention both in animal models and in humans after the discovery of the inflammatory reflex. The suggested control of gut immunity by the brain\u2013gut axis represents a novel therapeutic target suitable for bioelectronic intervention. In this review, we discuss the role of the inflammatory reflex in gut inflammation and the recent advances in the treatment of IBD by intervening with the brain\u2013gut axis through bioelectronic devices.<\/jats:p>","DOI":"10.1093\/intimm\/dxab018","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T20:53:43Z","timestamp":1619470423000},"page":"349-356","source":"Crossref","is-referenced-by-count":15,"title":["The brain\u2013gut axis, inflammatory bowel disease and bioelectronic medicine"],"prefix":"10.1093","volume":"33","author":[{"given":"Michael","family":"Eberhardson","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital of Link\u00f6ping , 581 91 Link\u00f6ping , Sweden"},{"name":"Department of Medicine, Center for Bioelectronic Medicine, Bioclinicum, Karolinska Institutet , 171 64 Stockholm , Sweden"},{"name":"Department of Health, Medicine and Caring Sciences, Link\u00f6ping University , 581 83 Link\u00f6ping , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaakov A","family":"Levine","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Bioelectronic Medicine, Bioclinicum, Karolinska Institutet , 171 64 Stockholm , Sweden"},{"name":"SetPoint Medical , Valencia, CA 91355 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Tarnawski","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Bioelectronic Medicine, Bioclinicum, Karolinska Institutet , 171 64 Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peder S","family":"Olofsson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Bioelectronic Medicine, Bioclinicum, Karolinska Institutet , 171 64 Stockholm , Sweden"},{"name":"Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research , Manhasset, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,29]]},"reference":[{"key":"2022070617342364000_CIT0001","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.crohns.2013.01.010","article-title":"The burden of inflammatory bowel disease in Europe","volume":"7","author":"Burisch","year":"2013","journal-title":"J. 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Immunol."},{"key":"2022070617342364000_CIT0006","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1053\/j.gastro.2006.08.016","article-title":"The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model","volume":"131","author":"Ghia","year":"2006","journal-title":"Gastroenterology"},{"key":"2022070617342364000_CIT0007","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1111\/nmo.12792","article-title":"Chronic vagus nerve stimulation in Crohn\u2019s disease: a 6-month follow-up pilot study","volume":"28","author":"Bonaz","year":"2016","journal-title":"Neurogastroenterol. Motil."},{"key":"2022070617342364000_CIT0008","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/ibd\/izaa004","article-title":"Interrogating the gut\u2013brain axis in the context of inflammatory bowel disease: a translational approach","volume":"26","author":"Collins","year":"2020","journal-title":"Inflamm. 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(Lond.)"},{"key":"2022070617342364000_CIT0016","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1210\/en.2013-1142","article-title":"GPR41\/FFAR3 and GPR43\/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes","volume":"154","author":"N\u00f8hr","year":"2013","journal-title":"Endocrinology"},{"key":"2022070617342364000_CIT0017","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.neuropharm.2013.10.031","article-title":"High doses of the histone deacetylase inhibitor sodium butyrate trigger a stress-like response","volume":"79","author":"Gagliano","year":"2014","journal-title":"Neuropharmacology"},{"key":"2022070617342364000_CIT0018","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.physbeh.2011.03.012","article-title":"Protein-induced satiety is abolished in the absence of intestinal gluconeogenesis","volume":"105","author":"Penhoat","year":"2011","journal-title":"Physiol. 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Metab."},{"key":"2022070617342364000_CIT0022","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1365-2672.2012.05344.x","article-title":"\u03b3-Aminobutyric acid production by culturable bacteria from the human intestine","volume":"113","author":"Barrett","year":"2012","journal-title":"J. Appl. Microbiol."},{"key":"2022070617342364000_CIT0023","doi-asserted-by":"crossref","first-page":"545","DOI":"10.2307\/3281505","article-title":"The bacterial flora of the intestine of Ascaris suum and 5-hydroxytryptamine production","volume":"72","author":"Hsu","year":"1986","journal-title":"J. Parasitol."},{"key":"2022070617342364000_CIT0024","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1073\/pnas.0812874106","article-title":"Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites","volume":"106","author":"Wikoff","year":"2009","journal-title":"Proc. Natl Acad. Sci. 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Med."},{"key":"2022070617342364000_CIT0034","doi-asserted-by":"crossref","first-page":"11008","DOI":"10.1073\/pnas.0803237105","article-title":"Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia","volume":"105","author":"Rosas-Ballina","year":"2008","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2022070617342364000_CIT0035","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.coi.2020.09.007","article-title":"Neuro-innate immune interactions in gut mucosal immunity","volume":"68","author":"Kulkarni","year":"2021","journal-title":"Curr. Opin. Immunol."},{"key":"2022070617342364000_CIT0036","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/ecco-jcc\/jjw168","article-title":"3rd European evidence-based consensus on the diagnosis and management of Crohn\u2019s disease 2016: part 1: diagnosis and medical management","volume":"11","author":"Gomoll\u00f3n","year":"2017","journal-title":"J. Crohns Colitis"},{"key":"2022070617342364000_CIT0037","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.crohns.2012.09.003","article-title":"Second European evidence-based consensus on the diagnosis and management of ulcerative colitis: part 1: definitions and diagnosis","volume":"6","author":"Dignass","year":"2012","journal-title":"J. Crohns Colitis"},{"key":"2022070617342364000_CIT0038","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/apt.12528","article-title":"Nationwide prevalence of inflammatory bowel disease in Sweden: a population-based register study","volume":"39","author":"B\u00fcsch","year":"2014","journal-title":"Aliment. Pharmacol. Ther."},{"key":"2022070617342364000_CIT0039","doi-asserted-by":"crossref","first-page":"7247238","DOI":"10.1155\/2019\/7247238","article-title":"A comprehensive review and update on the pathogenesis of inflammatory bowel disease","volume":"2019","author":"Guan","year":"2019","journal-title":"J. Immunol. Res."},{"key":"2022070617342364000_CIT0040","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/intimm\/dxaa062","article-title":"ATG16L1 negatively regulates RICK\/RIP2-mediated innate immune responses","volume":"33","author":"Honjo","year":"2020","journal-title":"Int. Immunol."},{"key":"2022070617342364000_CIT0041","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/ni.1722","article-title":"A Crohn\u2019s disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1","volume":"10","author":"Noguchi","year":"2009","journal-title":"Nat. Immunol."},{"key":"2022070617342364000_CIT0042","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1016\/j.cub.2004.12.032","article-title":"The Crohn\u2019s disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO","volume":"14","author":"Abbott","year":"2004","journal-title":"Curr. Biol."},{"key":"2022070617342364000_CIT0043","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1080\/15548627.2019.1635384","article-title":"New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD","volume":"16","author":"Larabi","year":"2020","journal-title":"Autophagy"},{"key":"2022070617342364000_CIT0044","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ni.1823","article-title":"Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry","volume":"11","author":"Travassos","year":"2010","journal-title":"Nat. Immunol."},{"key":"2022070617342364000_CIT0045","doi-asserted-by":"crossref","first-page":"e3391","DOI":"10.1371\/journal.pone.0003391","article-title":"Impaired autophagy of an intracellular pathogen induced by a Crohn\u2019s disease associated ATG16L1 variant","volume":"3","author":"Kuballa","year":"2008","journal-title":"PLoS ONE"},{"key":"2022070617342364000_CIT0046","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nm.2069","article-title":"NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation","volume":"16","author":"Cooney","year":"2010","journal-title":"Nat. Med."},{"key":"2022070617342364000_CIT0047","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/ng1954","article-title":"A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1","volume":"39","author":"Hampe","year":"2007","journal-title":"Nat. Genet."},{"key":"2022070617342364000_CIT0048","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/ng2032","article-title":"Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis","volume":"39","author":"Rioux","year":"2007","journal-title":"Nat. Genet."},{"key":"2022070617342364000_CIT0049","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.immuni.2010.08.010","article-title":"Interleukin-23 drives intestinal inflammation through direct activity on T cells","volume":"33","author":"Ahern","year":"2010","journal-title":"Immunity"},{"key":"2022070617342364000_CIT0050","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/ng.3359","article-title":"Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations","volume":"47","author":"Liu","year":"2015","journal-title":"Nat. Genet."},{"key":"2022070617342364000_CIT0051","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nri3430","article-title":"Role of the gut microbiota in immunity and inflammatory disease","volume":"13","author":"Kamada","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"2022070617342364000_CIT0052","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/0140-6736(91)90663-A","article-title":"Effect of faecal stream diversion on recurrence of Crohn\u2019s disease in the neoterminal ileum","volume":"338","author":"Rutgeerts","year":"1991","journal-title":"Lancet"},{"key":"2022070617342364000_CIT0053","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1084\/jem.180.6.2359","article-title":"The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats","volume":"180","author":"Taurog","year":"1994","journal-title":"J. Exp. Med."},{"key":"2022070617342364000_CIT0054","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.1128\/IAI.66.11.5224-5231.1998","article-title":"Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice","volume":"66","author":"Sellon","year":"1998","journal-title":"Infect. Immun."},{"key":"2022070617342364000_CIT0055","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature11234","article-title":"2012. Structure, function and diversity of the healthy human microbiome","volume":"486","author":"Human Microbiome Project Consortium","journal-title":"Nature"},{"key":"2022070617342364000_CIT0056","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1172\/JCI200420295","article-title":"Bacterial flagellin is a dominant antigen in Crohn disease","volume":"113","author":"Lodes","year":"2004","journal-title":"J. Clin. 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Bowel Dis."},{"key":"2022070617342364000_CIT0059","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1053\/j.gastro.2019.11.294","article-title":"Differences in gut microbiota in patients with vs without inflammatory bowel diseases: a systematic review","volume":"158","author":"Pittayanon","year":"2020","journal-title":"Gastroenterology"},{"key":"2022070617342364000_CIT0060","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1136\/gutjnl-2013-306226","article-title":"Altered intestinal microbiota and blood T cell phenotype are shared by patients with Crohn\u2019s disease and their unaffected siblings","volume":"63","author":"Hedin","year":"2014","journal-title":"Gut"},{"key":"2022070617342364000_CIT0061","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1136\/gut.2010.223263","article-title":"Dysbiosis of the faecal microbiota in patients with Crohn\u2019s disease and their unaffected relatives","volume":"60","author":"Joossens","year":"2011","journal-title":"Gut"},{"key":"2022070617342364000_CIT0062","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1136\/gutjnl-2013-304833","article-title":"A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis","volume":"63","author":"Machiels","year":"2014","journal-title":"Gut"},{"key":"2022070617342364000_CIT0063","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1053\/j.gastro.2004.04.061","article-title":"High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn\u2019s disease","volume":"127","author":"Darfeuille-Michaud","year":"2004","journal-title":"Gastroenterology"},{"key":"2022070617342364000_CIT0064","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1136\/gutjnl-2011-301668","article-title":"Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn\u2019s disease: unexpected results of a randomised, double-blind placebo-controlled trial","volume":"61","author":"Hueber","year":"2012","journal-title":"Gut"},{"key":"2022070617342364000_CIT0065","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1111\/j.1365-2036.2011.04612.x","article-title":"Review article: loss of response to anti-TNF treatments in Crohn\u2019s disease","volume":"33","author":"Ben-Horin","year":"2011","journal-title":"Aliment. 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Neurol."},{"key":"2022070617342364000_CIT0084","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3389\/fnins.2019.00877","article-title":"An effective method for acute vagus nerve stimulation in experimental inflammation","volume":"13","author":"Caravaca","year":"2019","journal-title":"Front. Neurosci."},{"key":"2022070617342364000_CIT0085","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2119\/molmed.2011.00405","article-title":"\u03b17 nicotinic acetylcholine receptor (\u03b17nAChR) expression in bone marrow-derived non-T cells is required for the inflammatory reflex","volume":"18","author":"Olofsson","year":"2012","journal-title":"Mol. 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Motil."},{"key":"2022070617342364000_CIT0100","doi-asserted-by":"crossref","first-page":"e105328","DOI":"10.1371\/journal.pone.0105328","article-title":"Relationship between vagal tone, cortisol, TNF-alpha, epinephrine and negative affects in Crohn\u2019s disease and irritable bowel syndrome","volume":"9","author":"Pellissier","year":"2014","journal-title":"PLoS ONE"},{"key":"2022070617342364000_CIT0101","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1111\/nmo.12865","article-title":"Autonomic nervous system function predicts the inflammatory response over three years in newly diagnosed ulcerative colitis patients","volume":"28","author":"Gunterberg","year":"2016","journal-title":"Neurogastroenterol. 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