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This family is mainly involved in the host defense mechanisms against bacteria, fungi and helminth infection by inducing cytokines and chemokines, recruiting neutrophils, inducing anti-microbial proteins and modifying T-helper cell differentiation. IL-17A and some other family cytokines are also involved in the development of psoriasis, psoriatic arthritis and ankylosing spondylitis by inducing inflammatory cytokines and chemokines, and antibodies against IL-17A as well as the receptor IL-17RA are being successfully used for the treatment of these diseases. Involvement in the development of inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis and tumors has also been suggested in animal disease models. In this review, we will briefly review the mechanisms by which IL-17 cytokines are involved in the development of these diseases and discuss possible treatment of inflammatory diseases by targeting IL-17 family members.<\/jats:p>","DOI":"10.1093\/intimm\/dxab075","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T21:00:00Z","timestamp":1633035600000},"page":"723-729","source":"Crossref","is-referenced-by-count":90,"title":["Interleukin-17 family members in health and disease"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2808-1327","authenticated-orcid":false,"given":"Soo-Hyun","family":"Chung","sequence":"first","affiliation":[{"name":"Research Institute for Biomedical Sciences, Tokyo University of Science , 2669 Yamazaki, Noda, Chiba , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4433-8949","authenticated-orcid":false,"given":"Xiao-Qi","family":"Ye","sequence":"additional","affiliation":[{"name":"Research Institute for Biomedical Sciences, Tokyo University of Science , 2669 Yamazaki, Noda, Chiba , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Iwakura","sequence":"additional","affiliation":[{"name":"Research Institute for Biomedical Sciences, Tokyo University of Science , 2669 Yamazaki, Noda, Chiba , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,10,6]]},"reference":[{"key":"2023120103461909700_CIT0001","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.immuni.2011.02.012","article-title":"Functional specialization of interleukin-17 family members","volume":"34","author":"Iwakura","year":"2011","journal-title":"Immunity"},{"key":"2023120103461909700_CIT0002","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.immuni.2019.03.021","article-title":"The IL-17 family of cytokines in health and disease","volume":"50","author":"McGeachy","year":"2019","journal-title":"Immunity"},{"key":"2023120103461909700_CIT0003","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.immuni.2020.02.004","article-title":"Structural analysis reveals that the cytokine IL-17F forms a homodimeric complex with receptor IL-17RC to drive IL-17RA-independent signaling","volume":"52","author":"Goepfert","year":"2020","journal-title":"Immunity"},{"key":"2023120103461909700_CIT0004","doi-asserted-by":"crossref","first-page":"eaau9657","DOI":"10.1126\/sciimmunol.aau9657","article-title":"Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation","volume":"4","author":"Su","year":"2019","journal-title":"Sci. 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