{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:27:33Z","timestamp":1740130053001,"version":"3.37.3"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T00:00:00Z","timestamp":1642118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100019270","name":"Shimizu Foundation for Immunology and Neuroscience","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100019270","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Japanese Society for Immunology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\u03b3\u03b4 T cells expressing V\u03b35V\u03b41 TCR originally develop in the embryonic thymus and migrate to the epidermis, forming dendritic epidermal T cells (DETCs) throughout life. It is thought that a TCR signal is essential for their development; e.g., lack of TCR signal-transducer ZAP70 significantly decreases DETC numbers. On the other hand, lack of ZAP70 does not affect V\u03b35V\u03b41+ T cells in the embryonic thymus; thus, the involvement of TCR signaling remains elusive. Here, we used SKG mice with attenuated TCR signaling rather than gene-knockout mice. In SKG mice, V\u03b35+ T cells showed a marked decrease [10% of wild-type (WT)] in adult epidermis; however, there was just a moderate decrease (50% of WT) in the embryonic thymus. In early postnatal epidermis in SKG mice, substantial numbers of V\u03b35+ T cells were observed (50% of WT). Their activation markers including CD122, a component of the IL-15 receptor indispensable for DETC proliferation, were comparable to those of WT. However, the V\u03b35+ T cells in SKG mice did not proliferate and form DETCs thereafter. Furthermore, in SKG\/+ mice, the number of thymic V\u03b35V\u03b41+ T cells increased, compared to SKG mice; however, the number of DETCs remained significantly lower than in WT, similar to SKG mice. Our results suggest that signaling via V\u03b35V\u03b41 TCR is indispensable for DETC development, with distinct contributions to embryonic development and postnatal proliferation.<\/jats:p>","DOI":"10.1093\/intimm\/dxac001","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T12:10:57Z","timestamp":1642075857000},"page":"263-276","source":"Crossref","is-referenced-by-count":2,"title":["V\u03b35V\u03b41 TCR signaling is required to different extents for embryonic versus postnatal development of DETCs"],"prefix":"10.1093","volume":"34","author":[{"given":"Koichi","family":"Sudo","sequence":"first","affiliation":[{"name":"Laboratory of Immunobiology, Department of Animal Development and Physiology, Division of Systemic Life Science, Graduate School of Biostudies, Kyoto University, Yoshida-Konoe, Sakyo, Kyoto 606-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takero","family":"Todoroki","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology, Department of Animal Development and Physiology, Division of Systemic Life Science, Graduate School of Biostudies, Kyoto University, Yoshida-Konoe, Sakyo, Kyoto 606-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyo","family":"Ka","sequence":"additional","affiliation":[{"name":"Central Institute for Experimental Animals, Kawasaki, Kanagawa 210-0821, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Takahara","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology, Department of Animal Development and Physiology, Division of Systemic Life Science, Graduate School of Biostudies, Kyoto University, Yoshida-Konoe, Sakyo, Kyoto 606-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,1,14]]},"reference":[{"key":"2022042016290275700_CIT0001","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0092-8674(85)90140-0","article-title":"Structure, organization, and somatic rearrangement of T cell gamma genes","volume":"40","author":"Hayday","year":"1985","journal-title":"Cell"},{"key":"2022042016290275700_CIT0002","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/0092-8674(86)90787-7","article-title":"Diversity, rearrangement, and expression of murine T cell gamma genes","volume":"45","author":"Garman","year":"1986","journal-title":"Cell"},{"key":"2022042016290275700_CIT0003","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/322836a0","article-title":"Diversity of murine gamma genes and expression in fetal and adult T lymphocytes","volume":"322","author":"Heilig","year":"1986","journal-title":"Nature"},{"key":"2022042016290275700_CIT0004","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nri3384","article-title":"Six-of-the-best: unique contributions of \u03b3\u03b4 T cells to immunology","volume":"13","author":"Vantourout","year":"2013","journal-title":"Nat. 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