{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:00:39Z","timestamp":1790694039896,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18H05282"],"award-info":[{"award-number":["JP18H05282"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19K08650"],"award-info":[{"award-number":["JP19K08650"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18K15924"],"award-info":[{"award-number":["JP18K15924"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19K17636"],"award-info":[{"award-number":["JP19K17636"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["J200705023"],"award-info":[{"award-number":["J200705023"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["J200705710"],"award-info":[{"award-number":["J200705710"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["J200705049"],"award-info":[{"award-number":["J200705049"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18cm016335"],"award-info":[{"award-number":["JP18cm016335"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18cm059042"],"award-info":[{"award-number":["JP18cm059042"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019085","name":"Japanese Respiratory Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019085","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Sarcoidosis is a complex, polygenic, inflammatory granulomatous multi-organ disease of unknown cause. The granulomatous inflammation in sarcoidosis is driven by the interplay between T cells and macrophages. Extracellular vesicles (EVs) play important roles in intercellular communication. We subjected serum EVs, isolated by size exclusion chromatography, from seven patients with sarcoidosis and five control subjects to non-targeted proteomics analysis. Non-targeted, label-free proteomics analysis detected 2292 proteins in serum EVs; 42 proteins were up-regulated in patients with sarcoidosis relative to control subjects; and 324 proteins were down-regulated. The protein signature of EVs from patients with sarcoidosis reflected disease characteristics such as antigen presentation and immunological disease. Candidate biomarkers were further verified by targeted proteomics analysis (selected reaction monitoring) in 46 patients and 10 control subjects. Notably, CD14 and lipopolysaccharide-binding protein (LBP) were validated by targeted proteomics analysis. Up-regulation of these proteins was further confirmed by immunoblotting, and their expression was strongly increased in macrophages of lung granulomatous lesions. Consistent with these findings, CD14 levels were increased in lipopolysaccharide-stimulated macrophages during multinucleation, concomitant with increased levels of CD14 and LBP in EVs. The area under the curve values of CD14 and LBP were 0.81 and 0.84, respectively, and further increased to 0.98 in combination with angiotensin-converting enzyme and soluble interleukin-2 receptor. These findings suggest that CD14 and LBP in serum EVs, which are associated with granulomatous pathogenesis, can improve the diagnostic accuracy in patients with sarcoidosis.<\/jats:p>","DOI":"10.1093\/intimm\/dxac009","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T20:18:29Z","timestamp":1647375509000},"page":"327-340","source":"Crossref","is-referenced-by-count":21,"title":["Identification of CD14 and lipopolysaccharide-binding protein as novel biomarkers for sarcoidosis using proteomics of serum extracellular vesicles"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1665-3474","authenticated-orcid":false,"given":"Yu","family":"Futami","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University, Graduate School of Medicine , 2-2 Yamada-Oka, Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University, Graduate School of Medicine , 2-2 Yamada-Oka, Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Koba","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University, Graduate School of Medicine , 2-2 Yamada-Oka, Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryohei","family":"Narumi","sequence":"additional","affiliation":[{"name":"Laboratory of Proteome Research, National Institutes of Biomedical Innovation, Health and Nutrition , 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosui","family":"Nojima","sequence":"additional","affiliation":[{"name":"Laboratory of Bioinformatics, National Institutes of Biomedical Innovation, Health and Nutrition , 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Ito","sequence":"additional","affiliation":[{"name":"Laboratory of Bioinformatics, National Institutes of Biomedical Innovation, Health and Nutrition , 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mana","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University, Graduate School of Medicine , 2-2 Yamada-Oka, Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimiko","family":"Ishida","sequence":"additional","affiliation":[{"name":"Laboratory of Proteome Research, National Institutes of Biomedical Innovation, Health and Nutrition , 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanako","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University, Graduate School of Medicine , 2-2 Yamada-Oka, Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiro","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University, Graduate School of Medicine , 2-2 Yamada-Oka, Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoharu","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University, Graduate School of Medicine , 2-2 Yamada-Oka, Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Takimoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Centre , Nagasone-Cho 1180, Kita-Ku, Sakai, Osaka 591-8555 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuya","family":"Edahiro","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University, Graduate School of Medicine , 2-2 Yamada-Oka, Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Matsuki","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University, Graduate School of Medicine , 2-2 Yamada-Oka, Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Nojima","sequence":"additional","affiliation":[{"name":"Department of Pathology, Osaka University Graduate School of Medicine , 2-2 Yamada-Oka, Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University, Graduate School of Medicine , 2-2 Yamada-Oka, Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University, Graduate School of Medicine , 2-2 Yamada-Oka, Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kota","family":"Iwahori","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University, Graduate School of Medicine , 2-2 Yamada-Oka, Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izumi","family":"Nagatomo","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University, Graduate School of Medicine , 2-2 Yamada-Oka, Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Shirai","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University, Graduate School of Medicine , 2-2 Yamada-Oka, Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Suga","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University, Graduate School of Medicine , 2-2 Yamada-Oka, Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Satoh","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University, Graduate School of Medicine , 2-2 Yamada-Oka, Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Futami","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University, Graduate School of Medicine , 2-2 Yamada-Oka, Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University, Graduate School of Medicine , 2-2 Yamada-Oka, Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Shiroyama","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University, Graduate School of Medicine , 2-2 Yamada-Oka, Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Inoue","sequence":"additional","affiliation":[{"name":"Clinical Research Centre, National Hospital Organization Kinki-Chuo Chest Medical Centre , 1180 Nagasone-Cho, Kita-Ku, Sakai City, Osaka 591-8555 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Adachi","sequence":"additional","affiliation":[{"name":"Laboratory of Proteome Research, National Institutes of Biomedical Innovation, Health and Nutrition , 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Tomonaga","sequence":"additional","affiliation":[{"name":"Laboratory of Proteome Research, National Institutes of Biomedical Innovation, Health and Nutrition , 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Ueda","sequence":"additional","affiliation":[{"name":"Cancer Proteomics Group, Cancer Precision Medicine Centre, Japanese Foundation for Cancer Research , 3-8-31 Ariake, Koto, Tokyo 135-8550 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kumanogoh","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University, Graduate School of Medicine , 2-2 Yamada-Oka, Suita, Osaka 565-0871 , Japan"},{"name":"Laboratory of Immunopathology, World Premier International Immunology Frontier Research Centre, Osaka University , 2-2 Yamada-Oka, Suita, Osaka 565-0871 , Japan"},{"name":"Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University , 2-2 Yamada-Oka, Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,16]]},"reference":[{"key":"2022060413034956200_CIT0001","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1164\/ajrccm.160.2.ats4-99","article-title":"Statement on sarcoidosis","volume":"160","author":"Hunninghake","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"2022060413034956200_CIT0002","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S2213-2600(18)30064-X","article-title":"Pulmonary sarcoidosis","volume":"6","author":"Spagnolo","year":"2018","journal-title":"Lancet Respir. Med"},{"key":"2022060413034956200_CIT0003","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1164\/rccm.202002-0251ST","article-title":"Diagnosis and detection of sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline","volume":"201","author":"Crouser","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"2022060413034956200_CIT0004","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1080\/1744666X.2016.1196135","article-title":"Biomarkers in sarcoidosis","volume":"12","author":"Chopra","year":"2016","journal-title":"Expert Rev. Clin. Immunol"},{"key":"2022060413034956200_CIT0005","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1080\/1744666X.2019.1568240","article-title":"Clinically-useful serum biomarkers for diagnosis and prognosis of sarcoidosis","volume":"15","author":"Ramos-Casals","year":"2019","journal-title":"Expert Rev. Clin. Immunol"},{"key":"2022060413034956200_CIT0006","doi-asserted-by":"crossref","first-page":"S445","DOI":"10.1513\/AnnalsATS.201707-567OT","article-title":"Application of \u2018omics\u2019 and systems biology to sarcoidosis research","volume":"14","author":"Crouser","year":"2017","journal-title":"Ann. Am. Thorac. Soc"},{"key":"2022060413034956200_CIT0007","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1165\/rcmb.2020-0070PS","article-title":"Application of proteomics in sarcoidosis","volume":"63","author":"Guerrero","year":"2020","journal-title":"Am. J. Respir. Cell Mol. Biol"},{"key":"2022060413034956200_CIT0008","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1074\/mcp.M300031-MCP200","article-title":"Characterization of the low molecular weight human serum proteome","volume":"2","author":"Tirumalai","year":"2003","journal-title":"Mol. Cell. Proteomics"},{"key":"2022060413034956200_CIT0009","doi-asserted-by":"crossref","first-page":"e1800162","DOI":"10.1002\/pmic.201800162","article-title":"Proteomic analysis of extracellular vesicles for cancer diagnostics","volume":"19","author":"Wu","year":"2019","journal-title":"Proteomics"},{"key":"2022060413034956200_CIT0010","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrd3978","article-title":"Extracellular vesicles: biology and emerging therapeutic opportunities","volume":"12","author":"El Andaloussi","year":"2013","journal-title":"Nat. Rev. Drug Discov"},{"key":"2022060413034956200_CIT0011","doi-asserted-by":"crossref","first-page":"6232","DOI":"10.1038\/srep06232","article-title":"Antibody-coupled monolithic silica microtips for highthroughput molecular profiling of circulating exosomes","volume":"4","author":"Ueda","year":"2014","journal-title":"Sci. Rep"},{"key":"2022060413034956200_CIT0012","doi-asserted-by":"crossref","first-page":"e0145686","DOI":"10.1371\/journal.pone.0145686","article-title":"Isolation of exosomes from blood plasma: qualitative and quantitative comparison of ultracentrifugation and size exclusion chromatography methods","volume":"10","author":"Baranyai","year":"2015","journal-title":"PLoS One"},{"key":"2022060413034956200_CIT0013","doi-asserted-by":"crossref","first-page":"29289","DOI":"10.3402\/jev.v5.29289","article-title":"Isolation of biologically active and morphologically intact exosomes from plasma of patients with cancer","volume":"5","author":"Hong","year":"2016","journal-title":"J. Extracell. Vesicles"},{"key":"2022060413034956200_CIT0014","doi-asserted-by":"crossref","first-page":"00658-2020","DOI":"10.1183\/23120541.00658-2020","article-title":"Proteomics of serum extracellular vesicles identifies a novel COPD biomarker, fibulin-3 from elastic fibres","volume":"7","author":"Koba","year":"2021","journal-title":"ERJ Open Res"},{"key":"2022060413034956200_CIT0015","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1074\/mcp.M113.037093","article-title":"Discovery of colorectal cancer biomarker candidates by membrane proteomic analysis and subsequent verification using selected reaction monitoring (SRM) and tissue microarray (TMA) analysis","volume":"13","author":"Kume","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"key":"2022060413034956200_CIT0016","doi-asserted-by":"crossref","first-page":"38750","DOI":"10.1038\/srep38750","article-title":"Exosomal microRNA miR-1246 induces cell motility and invasion through the regulation of DENND2D in oral squamous cell carcinoma","volume":"6","author":"Sakha","year":"2016","journal-title":"Sci. Rep"},{"key":"2022060413034956200_CIT0017","doi-asserted-by":"crossref","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J. Extracell. Vesicles"},{"key":"2022060413034956200_CIT0018","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.1021\/pr3005474","article-title":"A strategy for large-scale phosphoproteomics and SRM-based validation of human breast cancer tissue samples","volume":"11","author":"Narumi","year":"2012","journal-title":"J. Proteome Res"},{"key":"2022060413034956200_CIT0019","doi-asserted-by":"crossref","first-page":"E3461","DOI":"10.1073\/pnas.1603799113","article-title":"Mass spectrometry-based absolute quantification reveals rhythmic variation of mouse circadian clock proteins","volume":"113","author":"Narumi","year":"2016","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2022060413034956200_CIT0020","doi-asserted-by":"crossref","first-page":"12782","DOI":"10.1038\/s41598-017-13092-x","article-title":"Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics","volume":"7","author":"Shiromizu","year":"2017","journal-title":"Sci. Rep"},{"key":"2022060413034956200_CIT0021","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1093\/bioinformatics\/btq054","article-title":"Skyline: an open source document editor for creating and analyzing targeted proteomics experiments","volume":"26","author":"MacLean","year":"2010","journal-title":"Bioinformatics"},{"key":"2022060413034956200_CIT0022","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jprot.2017.03.016","article-title":"Comprehensive functional analysis of large lists of genes and proteins","volume":"171","author":"Mlecnik","year":"2018","journal-title":"J. Proteomics"},{"key":"2022060413034956200_CIT0023","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1378\/chest.105.2.349","article-title":"Expression of CD14 correlates with lung function impairment in pulmonary sarcoidosis","volume":"105","author":"Pforte","year":"1994","journal-title":"Chest"},{"key":"2022060413034956200_CIT0024","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0923-1811(02)00148-2","article-title":"Monocyte-derived multinucleated giant cells and sarcoidosis","volume":"31","author":"Okamoto","year":"2003","journal-title":"J. Dermatol. Sci"},{"key":"2022060413034956200_CIT0025","doi-asserted-by":"crossref","first-page":"6485","DOI":"10.4049\/jimmunol.0802797","article-title":"Tetraspanin CD9 negatively regulates lipopolysaccharide-induced macrophage activation and lung inflammation","volume":"182","author":"Suzuki","year":"2009","journal-title":"J. Immunol"},{"key":"2022060413034956200_CIT0026","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1083\/jcb.200212031","article-title":"Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes","volume":"161","author":"Takeda","year":"2003","journal-title":"J. Cell Biol"},{"key":"2022060413034956200_CIT0027","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.cell.2018.12.002","article-title":"Activated PMN exosomes: pathogenic entities causing matrix destruction and disease in the lung","volume":"176","author":"Genschmer","year":"2019","journal-title":"Cell"},{"key":"2022060413034956200_CIT0028","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature14581","article-title":"Glypican-1 identifies cancer exosomes and detects early pancreatic cancer","volume":"523","author":"Melo","year":"2015","journal-title":"Nature"},{"key":"2022060413034956200_CIT0029","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature15756","article-title":"Tumour exosome integrins determine organotropic metastasis","volume":"527","author":"Hoshino","year":"2015","journal-title":"Nature"},{"key":"2022060413034956200_CIT0030","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1164\/rccm.200803-490OC","article-title":"Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis","volume":"179","author":"Crouser","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"2022060413034956200_CIT0031","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1164\/rccm.201106-1143OC","article-title":"Sarcoidosis blood transcriptome reflects lung inflammation and overlaps with tuberculosis","volume":"184","author":"Koth","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"2022060413034956200_CIT0032","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1183\/09031936.00039714","article-title":"Longitudinal analysis of sarcoidosis blood transcriptomic signatures and disease outcomes","volume":"44","author":"Su","year":"2014","journal-title":"Eur. Respir. J"},{"key":"2022060413034956200_CIT0033","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.jaci.2016.05.051","article-title":"Pulmonary sarcoidosis is associated with exosomal vitamin D-binding protein and inflammatory molecules","volume":"139","author":"Martinez-Bravo","year":"2017","journal-title":"J. Allergy Clin. Immunol"},{"key":"2022060413034956200_CIT0034","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/cc8850","article-title":"Role of CD14 in lung inflammation and infection","volume":"14","author":"Anas","year":"2010","journal-title":"Crit. Care"},{"key":"2022060413034956200_CIT0035","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1165\/rcmb.2010-0433TR","article-title":"Evidence for mycobacteria in sarcoidosis","volume":"45","author":"Brownell","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol"},{"key":"2022060413034956200_CIT0036","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/j.chest.2017.11.030","article-title":"The pathogenesis of pulmonary sarcoidosis and implications for treatment","volume":"153","author":"Patterson","year":"2018","journal-title":"Chest"},{"key":"2022060413034956200_CIT0037","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1038\/s41598-017-04109-6","article-title":"Identification of Jak-STAT signaling involvement in sarcoidosis severity via a novel microRNA-regulated peripheral blood mononuclear cell gene signature","volume":"7","author":"Zhou","year":"2017","journal-title":"Sci. Rep"},{"key":"2022060413034956200_CIT0038","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.clim.2009.04.010","article-title":"Hypothesis: sarcoidosis is a STAT1-mediated disease","volume":"132","author":"Rosenbaum","year":"2009","journal-title":"Clin. Immunol"},{"key":"2022060413034956200_CIT0039","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jaad.2019.05.098","article-title":"Janus kinase inhibition induces disease remission in cutaneous sarcoidosis and granuloma annulare","volume":"82","author":"Damsky","year":"2020","journal-title":"J. Am. Acad. Dermatol"},{"key":"2022060413034956200_CIT0040","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3109\/15419061003678810","article-title":"Spontaneous formation of multinucleated giant cells with bone resorbing activity by long culture of human peripheral blood CD14-positive monocytes in vitro","volume":"17","author":"Yuasa","year":"2010","journal-title":"Cell Commun. Adhes"},{"key":"2022060413034956200_CIT0041","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.3389\/fimmu.2020.01443","article-title":"Biomarkers in the diagnosis and prognosis of sarcoidosis: current use and future prospects","volume":"11","author":"Kraaijvanger","year":"2020","journal-title":"Front. Immunol"},{"key":"2022060413034956200_CIT0042","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jprot.2015.08.012","article-title":"A functional proteomics approach to the comprehension of sarcoidosis","volume":"128","author":"Landi","year":"2015","journal-title":"J. Proteomics"}],"container-title":["International Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/intimm\/advance-article-pdf\/doi\/10.1093\/intimm\/dxac009\/43771360\/dxac009.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/intimm\/article-pdf\/34\/6\/327\/43954310\/dxac009.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/intimm\/article-pdf\/34\/6\/327\/43954310\/dxac009.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T13:04:28Z","timestamp":1654347868000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/intimm\/article\/34\/6\/327\/6549731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,16]]},"references-count":42,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,3,16]]},"published-print":{"date-parts":[[2022,6,4]]}},"URL":"https:\/\/doi.org\/10.1093\/intimm\/dxac009","relation":{},"ISSN":["1460-2377"],"issn-type":[{"value":"1460-2377","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,6,1]]},"published":{"date-parts":[[2022,3,16]]}}}